메뉴 건너뛰기




Volumn 28, Issue 4, 2013, Pages 375-380

Does the recommended lymphocyte cytokinesis-block micronucleus assay for human biomonitoring actually detect DNA damage induced by occupational and environmental exposure to genotoxic chemicals?

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; CYTOCHALASIN B; PHYTOHEMAGGLUTININ; TOXIC SUBSTANCE;

EID: 84881645387     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/get026     Document Type: Review
Times cited : (25)

References (35)
  • 1
    • 34250187067 scopus 로고    scopus 로고
    • Cytokinesis-block micronucleus cytome assay
    • Fenech, M. (2007) Cytokinesis-block micronucleus cytome assay. Nat. Protoc., 2, 1084-1104.
    • (2007) Nat. Protoc. , vol.2 , pp. 1084-1104
    • Fenech, M.1
  • 3
    • 84858074690 scopus 로고    scopus 로고
    • Micronuclei-recent advances in their measurement, in understanding of molecular mechanisms and their association with environment, genetics and disease
    • Fenech, M. (2011) Micronuclei-recent advances in their measurement, in understanding of molecular mechanisms and their association with environment, genetics and disease. Mutagenesis, 26, 1-252.
    • (2011) Mutagenesis , vol.26 , pp. 1-252
    • Fenech, M.1
  • 5
    • 84868600924 scopus 로고    scopus 로고
    • Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture
    • Speit, G., Linsenmeyer, R., Schütz, P. and Kuehner, S. (2012) Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis, 27, 743-747.
    • (2012) Mutagenesis , vol.27 , pp. 743-747
    • Speit, G.1    Linsenmeyer, R.2    Schütz, P.3    Kuehner, S.4
  • 6
    • 84876537433 scopus 로고    scopus 로고
    • RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture
    • Fenech, M., Kirsch-Volders, M. (2013) RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis, 28, 367-369.
    • (2013) Mutagenesis , vol.28 , pp. 367-369
    • Fenech, M.1    Kirsch-Volders, M.2
  • 7
    • 84876533805 scopus 로고    scopus 로고
    • RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture
    • Speit, G. (2012) RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis, 28, 371-374.
    • (2012) Mutagenesis , vol.28 , pp. 371-374
    • Speit, G.1
  • 8
    • 78650639748 scopus 로고    scopus 로고
    • The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells-past, present and future
    • Fenech, M., Holland, N., Zeiger, E., et al. (2011) The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells-past, present and future. Mutagenesis, 26, 239-245.
    • (2011) Mutagenesis , vol.26 , pp. 239-245
    • Fenech, M.1    Holland, N.2    Zeiger, E.3
  • 9
    • 0016588402 scopus 로고
    • The human leukocyte test system. VII. Further investigations concerning micronucleus-derived premature chromosome condensation
    • Obe, G. and Beek, B. (1975) The human leukocyte test system. VII. Further investigations concerning micronucleus-derived premature chromosome condensation. Humangenetik, 30, 143-154.
    • (1975) Humangenetik , vol.30 , pp. 143-154
    • Obe, G.1    Beek, B.2
  • 10
    • 70149107457 scopus 로고    scopus 로고
    • DNA lesions sequestered in micronuclei induce a local defective-damage response
    • Terradas, M., Martín, M., Tusell, L. and Genescà, A. (2009) DNA lesions sequestered in micronuclei induce a local defective-damage response. DNA Repair (Amst)., 8, 1225-1234.
    • (2009) DNA Repair (Amst). , vol.8 , pp. 1225-1234
    • Terradas, M.1    Martín, M.2    Tusell, L.3    Genescà, A.4
  • 11
    • 80052762819 scopus 로고    scopus 로고
    • The in vitro MN assay in 2011: Origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance
    • Kirsch-Volders, M., Plas, G., Elhajouji, A., Lukamowicz, M., Gonzalez, L., Vande Loock, K. and Decordier, I. (2011) The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance. Arch. Toxicol., 85, 873-899.
    • (2011) Arch. Toxicol. , vol.85 , pp. 873-899
    • Kirsch-Volders, M.1    Plas, G.2    Elhajouji, A.3    Lukamowicz, M.4    Gonzalez, L.5    Vande Loock, K.6    Decordier, I.7
  • 12
    • 0036020643 scopus 로고    scopus 로고
    • Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules
    • Decordier, I., Dillen, L., Cundari, E. and Kirsch-Volders, M. (2002) Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules. Mutagenesis, 17, 337-344.
    • (2002) Mutagenesis , vol.17 , pp. 337-344
    • Decordier, I.1    Dillen, L.2    Cundari, E.3    Kirsch-Volders, M.4
  • 14
    • 0035170551 scopus 로고    scopus 로고
    • Inclusion of micronuclei in nondivided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes
    • Kirsch-Volders, M. and Fenech, M. (2001) Inclusion of micronuclei in nondivided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis, 16, 51-58.
    • (2001) Mutagenesis , vol.16 , pp. 51-58
    • Kirsch-Volders, M.1    Fenech, M.2
  • 15
    • 0030774496 scopus 로고    scopus 로고
    • A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in human populations-experiences from the Chernobyl catastrophe
    • Fenech, M., Perepetskaya, G. and Mikhalevich, L. (1997) A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in human populations-experiences from the Chernobyl catastrophe. Environ. Mol. Mutagen., 30, 112-118.
    • (1997) Environ. Mol. Mutagen. , vol.30 , pp. 112-118
    • Fenech, M.1    Perepetskaya, G.2    Mikhalevich, L.3
  • 16
    • 78650653797 scopus 로고    scopus 로고
    • The in vivo or ex vivo origin of micronuclei measured in human biomonitoring studies
    • Speit, G., Zeller, J. and Neuss, S. (2011) The in vivo or ex vivo origin of micronuclei measured in human biomonitoring studies. Mutagenesis, 26, 107-110.
    • (2011) Mutagenesis , vol.26 , pp. 107-110
    • Speit, G.1    Zeller, J.2    Neuss, S.3
  • 18
    • 67650242889 scopus 로고    scopus 로고
    • Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage
    • Arsoy, N. S., Neuss, S., Wessendorf, S., Bommer, M., Viardot, A., Schütz, P. and Speit, G. (2009) Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage. Mutagenesis, 24, 351-357.
    • (2009) Mutagenesis , vol.24 , pp. 351-357
    • Arsoy, N.S.1    Neuss, S.2    Wessendorf, S.3    Bommer, M.4    Viardot, A.5    Schütz, P.6    Speit, G.7
  • 19
    • 0015576449 scopus 로고
    • The fate of chromosome aberrations
    • Carrano, A. V. and Heddle, J. A. (1973) The fate of chromosome aberrations. J. Theor. Biol., 38, 289-304.
    • (1973) J. Theor. Biol. , vol.38 , pp. 289-304
    • Carrano, A.V.1    Heddle, J.A.2
  • 20
    • 0022992648 scopus 로고
    • Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases
    • Bauchinger, M., Schmid, E. and Braselmann, H. (1986) Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases. Radiat. Environ. Biophys., 25, 253-260.
    • (1986) Radiat. Environ. Biophys. , vol.25 , pp. 253-260
    • Bauchinger, M.1    Schmid, E.2    Braselmann, H.3
  • 21
    • 0343290250 scopus 로고    scopus 로고
    • Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes
    • Boei, J. J., Vermeulen, S. and Natarajan, A. T. (1996) Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes. Mutat. Res., 349, 127-135.
    • (1996) Mutat. Res. , vol.349 , pp. 127-135
    • Boei, J.J.1    Vermeulen, S.2    Natarajan, A.T.3
  • 22
    • 0032911639 scopus 로고    scopus 로고
    • Analysis by FISH of the spectrum of chromosome aberrations induced by X-rays in G0 human lymphocytes and their fate through mitotic divisions in culture
    • Hoffmann, G. R., Sayer, A. M., Joiner, E. E., McFee, A. F. and Littlefield, L. G. (1999) Analysis by FISH of the spectrum of chromosome aberrations induced by X-rays in G0 human lymphocytes and their fate through mitotic divisions in culture. Environ. Mol. Mutagen., 33, 94-110.
    • (1999) Environ. Mol. Mutagen. , vol.33 , pp. 94-110
    • Hoffmann, G.R.1    Sayer, A.M.2    Joiner, E.E.3    McFee, A.F.4    Littlefield, L.G.5
  • 24
    • 0034255796 scopus 로고    scopus 로고
    • IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety
    • Albertini, R. J., Anderson, D., Douglas, G. R., et al. (2000) IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutat. Res., 463, 111-172.
    • (2000) Mutat. Res. , vol.463 , pp. 111-172
    • Albertini, R.J.1    Anderson, D.2    Douglas, G.R.3
  • 25
    • 33846070797 scopus 로고    scopus 로고
    • Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies
    • Schmid, O. and Speit, G. (2007) Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies. Mutagenesis, 22, 69-74.
    • (2007) Mutagenesis , vol.22 , pp. 69-74
    • Schmid, O.1    Speit, G.2
  • 26
    • 79959706743 scopus 로고    scopus 로고
    • Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions
    • Zeller, J., Neuss, S., Mueller, J. U., et al. (2011) Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions. Mutagenesis, 26, 555-561.
    • (2011) Mutagenesis , vol.26 , pp. 555-561
    • Zeller, J.1    Neuss, S.2    Mueller, J.U.3
  • 27
    • 0018314916 scopus 로고
    • BISACK analysis of the phytohaemagglutinin-induced proliferation of human peripheral lymphocytes
    • Tice, R., Thorne, P. and Schneider, E. L. (1979) BISACK analysis of the phytohaemagglutinin-induced proliferation of human peripheral lymphocytes. Cell Tissue Kinet., 12, 1-9.
    • (1979) Cell Tissue Kinet. , vol.12 , pp. 1-9
    • Tice, R.1    Thorne, P.2    Schneider, E.L.3
  • 29
    • 54249099282 scopus 로고    scopus 로고
    • Micronuclei related to anti-B[a]PDE-DNA adduct in peripheral blood lymphocytes of heavily polycyclic aromatic hydrocarbonexposed nonsmoking coke-oven workers and controls
    • Pavanello, S., Kapka, L., Siwinska, E., Mielzyñska, D., Bolognesi, C. and Clonfero, E. (2008) Micronuclei related to anti-B[a]PDE-DNA adduct in peripheral blood lymphocytes of heavily polycyclic aromatic hydrocarbonexposed nonsmoking coke-oven workers and controls. Cancer Epidemiol. Biomarkers Prev., 17, 2795-2799.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 2795-2799
    • Pavanello, S.1    Kapka, L.2    Siwinska, E.3    Mielzyñska, D.4    Bolognesi, C.5    Clonfero, E.6
  • 30
    • 70350463547 scopus 로고    scopus 로고
    • Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution
    • Pedersen, M., Wichmann, J., Autrup, H., et al. (2009) Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ. Res., 109, 1012-1020.
    • (2009) Environ. Res. , vol.109 , pp. 1012-1020
    • Pedersen, M.1    Wichmann, J.2    Autrup, H.3
  • 31
    • 0026593221 scopus 로고
    • Conversion of excision-repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes
    • Fenech, M. and Neville, S. (1992) Conversion of excision-repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes. Environ. Mol. Mutagen., 19, 27-36.
    • (1992) Environ. Mol. Mutagen. , vol.19 , pp. 27-36
    • Fenech, M.1    Neville, S.2
  • 32
    • 0028907998 scopus 로고
    • The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair
    • Surrallés, J., Xamena, N., Creus, A. and Marcos, R. (1995) The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair. Mutat. Res., 342, 43-59.
    • (1995) Mutat. Res. , vol.342 , pp. 43-59
    • Surrallés, J.1    Xamena, N.2    Creus, A.3    Marcos, R.4
  • 33
    • 0032875309 scopus 로고    scopus 로고
    • Processing of DNA damage induced by hydrogen peroxide and methyl methanesulfonate in human lymphocytes: Analysis by alkaline single cell gel electrophoresis and cytogenetic methods
    • Andreoli, C., Leopardi, P., Rossi, S. and Crebelli, R. (1999) Processing of DNA damage induced by hydrogen peroxide and methyl methanesulfonate in human lymphocytes: analysis by alkaline single cell gel electrophoresis and cytogenetic methods. Mutagenesis, 14, 497-504.
    • (1999) Mutagenesis , vol.14 , pp. 497-504
    • Andreoli, C.1    Leopardi, P.2    Rossi, S.3    Crebelli, R.4
  • 34
    • 0037229175 scopus 로고    scopus 로고
    • Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: Effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C
    • Leopardi, P., Zijno, A., Marcon, F., et al. (2003) Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C. Environ. Mol. Mutagen., 41, 126-130.
    • (2003) Environ. Mol. Mutagen. , vol.41 , pp. 126-130
    • Leopardi, P.1    Zijno, A.2    Marcon, F.3
  • 35
    • 49849105614 scopus 로고    scopus 로고
    • Micronuclei frequency in peripheral blood lymphocytes of cancer patients: A meta-analysis
    • Iarmarcovai, G., Ceppi, M., Botta, A., Orsière, T. and Bonassi, S. (2008) Micronuclei frequency in peripheral blood lymphocytes of cancer patients: a meta-analysis. Mutat. Res., 659, 274-283.
    • (2008) Mutat. Res. , vol.659 , pp. 274-283
    • Iarmarcovai, G.1    Ceppi, M.2    Botta, A.3    Orsière, T.4    Bonassi, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.