RE: Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture (Mutagenesis, 27, 743-747, 2012)

Mutagenesis

Volumn 28, Issue 3, 2013, Pages 371-374

  Speit, Günter ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; CLASTOGEN; DOUBLE STRANDED DNA; ENVIRONMENTAL MUTAGEN; MITOMYCIN;

BIOLOGICAL MONITORING; CANCER RISK; CHEMICAL MUTAGENESIS; CHROMATID; COMET ASSAY; CYTOKINESIS; CYTOKINESIS BLOCK MICRONUCLEUS TEST; DNA DAMAGE; DNA STRAND BREAKAGE; ENVIRONMENTAL EXPOSURE; EXCISION REPAIR; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; LETTER; LONG TERM EXPOSURE; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MICRONUCLEUS; MICRONUCLEUS TEST; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

CYTOKINESIS; DNA DAMAGE; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS;

EID: 84876533805     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/ges082     Document Type: Letter

References (8)

1. Speit, G., Linsenmeyer, R., Schütz, P. and Kuehner, S. (2012) Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis, 27, 743-747.
2. OECD. (2010) Guideline for the Testing of Chemicals No. 487: In Vitro Mammalian Cell Micronucleus Test (MNvit). OECD, Paris, France.
3. Fenech, M. and Neville, S. (1992) Conversion of excision-repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes. Environ. Mol. Mutagen., 19, 27-36.
4. Leopardi, P., Zijno, A., Marcon, F. et al. (2003) Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C. Environ Mol. Mutagen., 41, 126-130.
5. Arsoy, N. S., Neuss, S., Wessendorf, S., Bommer, M., Viardot, A., Schütz, P. and Speit, G. (2009) Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage. Mutagenesis, 24, 351-357.
6. Bonassi, S., Znaor, A., Ceppi, M. et al. (2007) An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis, 28, 625-631.
7. Speit, G., Zeller, J. and Neuss, S. (2011) The in vivo or ex vivo origin of micronuclei measured in human biomonitoring studies. Mutagenesis, 26, 107-110.
8. Collins, A. R., Oscoz, A. A., Brunborg, G., Gaivão, I., Giovannelli, L., Kruszewski, M., Smith, C. C. and Stetina, R. (2008) The comet assay: topical issues. Mutagenesis, 23, 143-151.