Gallium-68: A systematic review of its nononcological applications

Nuclear Medicine Communications

Volumn 34, Issue 9, 2013, Pages 834-854

  Vorster, Mariza ^a   Maes, Alex ^a,b,c   Van Dewiele, Christophe ^a,d   Sathekge, Mike ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b AZ Groeninge ^*  (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

68Ga tracer; clinical applications; generator based PET; infection imaging; nononcology review

Indexed keywords

ALBUMIN TC 99M; APOTRANSFERRIN GA 68; BAPEN GA 68; CHLORIDE GA 68; CITRATE GA 68; DOTA NOC GA 68; DOTA RSA GA 68; DTPA STREPTOKINASE GA 67; EDTMP GA 68; FERRIOXAMINE GA 68; FLUORODEOXYGLUCOSE F 18; GALLIUM 68; GALLIUM EDETATE GA 68; MACROSALB GA 68; MEDRONATE TECHNETIUM TC 99M; MICROSPHERE GA 68; MPO GA 67; NODAPA GLUCOSAMINE GA 68; NOTA BP GA 68; PASIREOTIDE TETRAXETAN GALLIUM GA 68; RADIOPHARMACEUTICAL AGENT; SODIUM FLUORIDE F 18; TAFC GA 68; TRANSFERRIN GA 67; TRIPOLYPHOSPHATE GA 68; UNCLASSIFIED DRUG;

AUTORADIOGRAPHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG UPTAKE; GOLD STANDARD; HUMAN; ISOTOPE LABELING; NONHUMAN; OSTEOMYELITIS; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYSTEMATIC REVIEW;

ANIMALS; DIAGNOSTIC IMAGING; GALLIUM RADIOISOTOPES; HUMANS;

EID: 84881552520     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32836341e5     Document Type: Review

References (74)

1. AL-Nahhas A, Win Z, Szyszko T, Singh A, Khan S, Rubello D. What can gallium-68 PET add to receptor and molecular imaging? Eur J Nucl Med Mol Imaging 2007; 34:1897-1901.
2. Treglia G, Castaldi P, Rindi G, Giordano A, Rufini V. Diagnostic performance of gallium-68 somatostatin receptor PET and PET/CT in patients with thoracic and gastroenteropancreatic neuroendocrine tumours: a meta-analysis. Endocrine 2012; 42:80-87.
3. Khan MU, Khan S, El-Refaie S, Win Z, Rubello D, Al-Nahhas A. Clinical indications for gallium-68 positron emission tomography imaging. Eur J Surg Oncol 2009; 35:561-567.
4. Al-Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, et al. Gallium-68 PET: a new frontier in receptor cancer imaging. Anticancer Res 2007; 27:4087-4094.
5. Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151:264-269.
6. 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus. Eur J Nucl Med Mol Imaging 2005; 32:1259-1268.
7. 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection. Nucl Med Biol 2011; 38:393-398.
8. Lankinen PP, Mäkinen TJT, Pöyhönen TAT, Virsu PP, Salomäki SS, Hakanen AJA, et al. (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones. Eur J Nucl Med Mol Imaging 2008; 35:352-364.
9. 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis. Nucl Med Biol 2009; 36:11-21.
10. 68Ga]-EDTMP. Nucl Med Biol 2007; 34:391-397.
11. 68Ga-Citrate PET/CT for evaluating patients with infections of the bone: preliminary results. J Nucl Med 2010; 51:1932-1936.
12. 68Ga-chelate-conjugated bisphosphonate as a bone-seeking agent for PET imaging. Nucl Med Biol 2011; 38:83-90.
13. 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. Bioorg Med Chem Lett 2008; 18:5364-5367.
14. Schuster DP. The evaluation of lung function with PET. Semin Nucl Med 1998; 28:341-351.
15. Mintun MA, Dennis DR, Welch MJ, Mathias CJ, Schuster DP. Measurements of pulmonary vascular permeability with PET and gallium-68 transferrin. J Nucl Med 1987; 28:1704-1716.
16. Schuster DP, Markham J, Welch M. Positron emission tomography measurements of pulmonary vascular permeability with Ga-68 transferrin or C-11 methylalbumin. Crit Care Med 1998; 26:518-525.
17. Schuster DP, Stark T, Stephenson J, Royal H. Detecting lung injury in patients with pulmonary edema. Intensive Care Med 2002; 28:1246-1253.
18. Kotzerke J, Andreeff M, Wunderlich G. PET aerosol lung scintigraphy using Galligas. Eur J Nucl Med Mol Imaging 2010; 37:175-177.
19. 68GaCl as the label. J Nucl Med 2011; 52:206-209.
20. 68Ga PET/CT ventilation-perfusion imaging for pulmonary embolism: a pilot study with comparison to conventional scintigraphy. J Nucl Med 2011; 52: 1513-1519.
21. Ament SJ, Maus S, Reber H, Buchholz HG, Bausbacher N, Brochhausen C, et al. PET lung ventilation/perfusion imaging using (68)Ga aerosol (Galligas) and (68)Ga-labeled macroaggregated albumin. Recent Results Cancer Res 2013; 194:395-423.
22. 68Ga-DOTANOC PET/CT allows somatostatin receptor imaging in idiopathic pulmonary fibrosis: preliminary results. J Nucl Med 2010; 51:1950-1955.
23. 68Ga-Siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 2010; 51:639-645.
24. 68Ga-siderophores for infection imaging. Nucl Med Biol 2012; 39:361-369.
25. Petrik MM, Franssen GMG, Haas HH, Laverman PP, Hörtnagl CC, Schrettl MM, et al. Preclinical evaluation of two (68)Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging. Eur J Nucl Med Mol Imaging 2012; 39:1175-1183.
26. Bomanji J, Almuhaideb A, Zumla A. Combined PET and X-ray computed tomography imaging in pulmonary infections and inflammation. Curr Opin Pulm Med 2011; 17:197-205.
27. Green MAM, Mathias CJC, Neumann WLW, Fanwick PEP, Janik MM, Deutsch EAE. Potential gallium-68 tracers for imaging the heart with PET: evaluation of four gallium complexes with functionalized tripodal tris(salicylaldimine) ligands. J Nucl Med 1993; 34:228-233.
28. 2sal)2BAPEN]. J Nucl Med 1993; 34:1127-1131.
29. 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study. Nucl Med Biol 2010; 37:149-155.
30. Hoffend J, Mier W, Schuhmacher J, Schmidt K, Dimitrakopoulou-Strauss A, Strauss LG, et al. Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo. Nucl Med Biol 2005; 32:287-292.
31. Plössl K, Chandra R, Qu W, Lieberman BP, Kung M-P, Zhou R, et al. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol 2008; 35:83-90.
32. 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs. Nucl Med Biol 2012; 39:715-723.
33. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice. Eur J Nucl Med Mol Imaging 2009; 36:2058-2067.
34. 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid and feasibility studies in mice. J Nucl Med 2008; 49:830-836.
35. Caforio ALP, Marcolongo R, Jahns R, Fu M, Felix SB, Iliceto S. Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. Heart Fail Rev 2012; 2012:1-18.
36. 68Ga-DOTATATE PET/CT: correlation with coronary calcium burden and risk factors. J Nucl Med 2010; 51:193-197.
37. 100/100 mice. EJNMMI Res 2010; 1:14-24.
38. Stoll H-P, Hutchins GD, Winkle WL, Nguyen AT, Appledorn CR, Janzen I, et al. Advantages of short-lived positron-emitting radioisotopes for intracoronary radiation therapy with liquid-filled balloons to prevent restenosis. J Nucl Med 2001; 42:1375-1383.
39. Karanikas G, Schmaljohann J, Rodrigues M, Chehne F, Granegger S, Sinzinger H. Examination of co-complexes for radiolabeling of platelets in positron emission tomographic studies. Thromb Res 1999; 94:111-115.
40. Jalilian AR, Mirazizi F, Nazem H, Shafaii K, Nasserian B, Sadeghpour H. Evaluation of radiolabeled streptokinase for thrombosis imaging. Iran J Nucl Med 2008; 16:34-40.
41. 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1. Clin Physiol Funct Imaging 2010; 30:75-78.
42. James AE, DeLand FH, Hodges FJ, Wagner HN. Cerebrospinal fluid (CSF) scanning: cisternography. Am J Roentgenol 1970; 110:74-87.
43. Hawkins RA, Phelps ME, Huang SC, Wapenski JA, Grimm PD, Greenberg P, et al. Simultaneous estimations of blood brain barrier (BBB) permeability and local cerebral blood volume (CBV) in human brain tumors with positron tomography and Ga-68 EDTA. J Nucl Med 1984; 25:5.
44. Friedland RP, Jagust WJ, Budinger TF, Yano Y, Huesman RH, Knittel B. Dynamic PET studies of blood-brain barrier permeability in Alzheimer's disease. J Nucl Med 1985; 26:5.
45. Pozzilli C, Bernardi S, Mansi L, Picozzi P, Iannotti F, Alfano B, et al. Quantitative assessment of blood-brain barrier permeability in multiple sclerosis using 68-Ga-EDTA and positron emission tomography. J Neurol Neurosurg Psychiatry 1988; 51:1058-1062.
46. Cutler CS, Giron MC, Reichert DE, Snyder AZ, Herrero P, Anderson CJ, et al. Evaluation of gallium-68 tris(2-mercaptobenzyl)amine: a complex with brain and myocardial uptake. Nucl Med Biol 1999; 26: 305-316.
47. McCarthy TJ, Banks WA, Farrell CL, Adamu S, Derdeyn CP, Snyder AZ, et al. Positron emission tomography shows that intrathecal leptin reaches the hypothalamus in baboons. J Pharmacol Exp Ther 2002; 301:878-883.
48. Anghileri LJL. A new Ga68-compound for kidney scanning. Int J Appl Radiat Isot 1968; 19:421-422.
49. Yamashita M, Inaba T, Kawase Y, Iiorii H, Wakita K, Fujii R, et al. Quantitative measurement of renal function using Ga-68-EDTA. Tohoku J Exp Med 1988; 155:207-208.
50. Szabo Z, Xia J, Mathews WB, Brown PR. Future direction of renal PET. Semin Nucl Med 2006; 36:36-50.
51. Szabo Z, Xia J, Mathews WB. Radiopharmaceuticals for renal positron emission tomography imaging. Semin Nucl Med 2008; 38:20-31.
52. Nanni C, Marangoni A, Quarta C, Di Pierro D, Rizzello A, Trespidi S, et al. Small animal PET for the evaluation of an animal model of genital infection. Clin Physiol Funct Imaging 2009; 29:187-192.
53. Schuhmacher JJ, Maier-Borst WW, Wellman HNH. Liver and kidney imaging with Ga-68-labeled dihydroxyanthraquinones. J Nucl Med 1980; 21:983-987.
54. Schuhmacher J, Matys R, Hauser H. Ga-68-labeled tetrabromophthalein (Ga-68 BP-IDA) for positron imaging of hepatobiliary function: concise communication. J Nucl Med 1983; 24:593-602.
55. Haubner R, Vera DR, Farshchi-Heydari S, Helbok A, Rangger C, Putzer D, Virgolini IJ. Development of (68)Ga-labelled DTPA galactosyl human serum albumin for liver function imaging. Eur J Nucl Med Mol Imaging 2013 [Epub ahead of print].
56. 68Ga citrate for routine clinical PET. Nucl Med Commun 2009; 30:542-545.
57. Kumar V, Boddeti DK, Evans SG, Angelides S. (68)Ga-Citrate-PET for diagnostic imaging of infection in rats and for intra-abdominal infection in a patient. Curr Radiopharm 2012; 5:71-75.
58. Galibert M, Sancey L, Renaudet O, Coll J, Dumy P, Boturyn D. Application of click-click chemistry to the synthesis of new multivalent RGD conjugates. Org Biomol Chem 2010; 8:5133-5138.
59. 68Ga-Schiff bases for myocardial imaging. Nucl Med Biology 2010; 37:691.
60. Hany TF, Strobel K. PET/CT in pancreatic cancer. New concepts in diagnosis and therapy of pancreatic adenocarcinoma. Heidelberg: Springer Berlin; 2010. pp. 91-99.
61. 68Ga-MAA. Nuklearmedizin 2010; 50:37-38.
62. 68Ga-labeled Ga(III)- deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nucl Med Biol 2003; 30:725-731.
63. Low PS, Henne WA, Doorneweerd DD. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res 2008; 41:120-129.
64. 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography. Bioorg Med Chem 2010; 18:5274-5281.
65. 68Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography. Nucl Med Biol 2011; 38:371-379.
66. Pichler R, Sonnberger M, Dorninger C, Assar H, Stojakovic T. Ga-68-DOTA-NOC PET/CT reveals active Graves' orbitopathy in a single extraorbital muscle. Clin Nucl Med 2011; 36:910-911.
67. Roivainen AA, Jalkanen SS, Nanni CC. Gallium-labelled peptides for imaging of inflammation. Eur J Nucl Med Mol Imaging 2012; 39 (Suppl):S68-S77.
68. 99mTc-Labeled antimicrobial peptides for detection of bacterial and Candida albicans infections. J Nucl Med 2001; 42:788-794.
69. Ebenhan T, Chadwick N, Govender T, Kruger HG, Sathekge M, Zeevaart JR. Gallium-68 labelling of NOTA-peptide conjugates for imaging infection-especially tuberculosis. World J Nucl Med 2011; 10:73-89.
70. Ebenhan T, Govender T, Kruger G, Pulker T, Zeevaart JR, Sathekge M. Synthesis of Ga-68-NOTA-UBI-30-41 and in vivo bio-distribution in vervet monkeys towards potential PET/CT imaging of infection. J Nucl Med 2012; 53 (Suppl):1520.
71. 18F-FDG. Eur J Nucl Med Mol Imaging 2010; 37: 1918-1925.
72. 68Ga]NODAGA-RGD for imaging avb3 integrin expression. Eur J Nucl Med Mol Imaging 2011; 38:1303-1312.
73. 68Ga-labelled tracers in clinical routine? Eur J Nucl Med Mol Imaging 2007; 34:978-981.
74. 68Ga-labelled peptides into routine clinical use? Nucl Med Commun 2011; 32: 1109-1112.