NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5364-5367

  Riss, Patrick J ^a   Kroll, Carsten ^a   Nagel, Verena ^a   Rösch, Frank ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Bifunctional chelators; Gallium 68; Macrocycles; Molecular imaging; PET

Indexed keywords

1,4,7 TRIAZACYCLONONANE 1 ACETIC ACID 4,7 DI (4 ISOTHIOCYANATOPHENYL) ACETIC ACID; 1,4,7 TRIAZACYCLONONANE 1,4 DEACTIC ACID 7 (4 ISOTHIOCYANATOPHENYL) ACETIC ACID; 1,4,7 TRIAZACYCLONONANE 1,4 DIACETIC ACID 7 (4 HYDROXYPHENYL)ACETIC ACID; ACETIC ACID DERIVATIVE; CHELATING AGENT; GALLIUM 68; HETEROCYCLIC COMPOUND; MACROCYCLIC COMPOUND; PHENYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; CYCLIZATION; ISOTOPE LABELING; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN BINDING; SYNTHESIS;

CHELATING AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GALLIUM RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 1-RING; HYDROGEN-ION CONCENTRATION; ISOTOPE LABELING; MODELS, CHEMICAL; PHENYLACETATES; POSITRON-EMISSION TOMOGRAPHY; RADIOISOTOPES;

EID: 53349165505     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.054     Document Type: Article

References (15)

1. Zhernosekov K.P., Filosofov D.V., Baum R.P., Aschoff P., Bihl H., Razbash A., Jahn M., Jennewein M., and Rösch F. J. Nucl. Med. 48 (2007) 1741
2. Craig A.S., Parker D., Adams H., and Bailey N.A. J. Chem. Soc. Chem. Commun. (1989) 1793
3. Eisenwiener K.-P., Prata M.I.M., Buschmann I., Zhang H.W., Santos A.C., Wenger S., Reubi J.C., and Mäcke H.R. Bioconjugate Chem. 13 (2002) 530
4. André J.P., Maecke H.R., Zehnder M., Macko L., and Akyel K.G. Chem. Commun. (1998) 1301
5. Brechbiel M.W., McMurry T.J., and Gansow O.A. Tetrahedron 34 (1993) 3691
6. Cox J., Craig A., Helps I.M., Jankowski K., Parker D., Eaton M., Millican A., Millar K., Beeley N., and Boyce B. J. Chem. Soc., Perkin Trans. 1 (1990) 2567
7. Ziegler K., Schenck G., Krockow E.W., Siebert A., Wenz A., and Weber H. Liebigs Ann. 551 (1942) 1
8. Helps I.M., Parker D., Morphy J.R., and Chapman J. Tetrahedron 45 (1989) 219
9. Neises A., and Steglich W. Angew. Chem. Int., Ed. Engl. 17 (1978) 52213
10. Wohl A. Chem. Ber. 52 (1919) 51
11. Richman J.E., and Atkins T.J. J. Am. Chem. Soc. 96 (1974) 2268
12. Raßhofer W., and Vögtle F. Liebigs Ann. Chem. (1977) 1340
13. Diril H., Chang H.R., Nilges M.J., Zhang X., Potenza J.A., Schugar H.J., Isied S.S., and Hendrickson D.N. J. Am. Chem. Soc. 111 (1989) 5102
14. Horner L., and Winkelmann E.H. Angew. Chem. 7 (1959) 349
15. 11S requires 783.41.