Gallium-labelled peptides for imaging of inflammation

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue SUPPL.1, 2012, Pages

  Roivainen, Anne ^a,b   Jalkanen, Sirpa ^b,c   Nanni, Cristina ^d  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

DOTA peptide; Gallium 68; Infection; Inflammation; PET; RGD; Vascular adhesion protein 1

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); ARGINYLGLYCYLASPARTIC ACID; CHOLINE C 11; COPPER 64; DESFERRIFERRICROCIN GA 68; DESFERRITRIACETYLFUSARININE C GA 68; DOTANOC GA 68; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLUORODEOXYGLUCOSE F 18; GALLIUM 68; GALLIUM CHLORIDE; GALLIUM CHLORIDE GA 68; GALLIUM CITRATE GA 67; INDIUM 111; INTERCELLULAR ADHESION MOLECULE 1; MACROGOL; PADGEM PROTEIN; PEPTIDE; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN 9 TETRAXETAN GA 68; TECHNETIUM 99M; TETRAXETAN; TETRAXETAN ARGINYLGLYCYLASPARTIC ACID CU 64; TETRAXETAN ARGINYLGLYCYLASPARTIC ACID IN 111; TETRAXETAN ARGINYLGLYCYLASPARTIC ACID TC 99M; TETRAXETAN VASCULAR ADHESION PROTEIN 1 GA 68; TRACER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR ADHESION PROTEIN 1; VASCULAR CELL ADHESION MOLECULE 1; AOC3 PROTEIN, HUMAN; ARGINYL-GLYCYL-ASPARTIC ACID; CELL ADHESION MOLECULE; DIAGNOSTIC AGENT; GALLIUM; OLIGOPEPTIDE; RADIOPHARMACEUTICAL AGENT; SEMICARBAZIDE SENSITIVE AMINE OXIDASE VASCULAR ADHESION PROTEIN 1, MOUSE; SEMICARBAZIDE-SENSITIVE AMINE OXIDASE-VASCULAR ADHESION PROTEIN-1, MOUSE; SOMATOSTATIN RECEPTOR; VITRONECTIN RECEPTOR;

ATHEROSCLEROTIC PLAQUE; BACTERIAL INFECTION; BONE INFECTION; CANCER DIAGNOSIS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DERMATITIS; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISKITIS; DRUG DISTRIBUTION; DRUG HALF LIFE; HUMAN; IN VIVO STUDY; INFLAMMATION; INTERSTITIAL PNEUMONIA; LUNG FIBROSIS; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOMYELITIS; POSITRON EMISSION TOMOGRAPHY; RADIOGRAPHY; REVIEW; SCINTIGRAPHY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; WHOLE BODY PET; WOUND HEALING; ANIMAL; ATHEROSCLEROSIS; CHEMISTRY; FRACTURE HEALING; GENETICS; INFECTION; METABOLISM; MOUSE; MOUSE MUTANT; NEOPLASM; RAT; SCINTISCANNING;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ATHEROSCLEROSIS; CELL ADHESION MOLECULES; FRACTURE HEALING; GALLIUM RADIOISOTOPES; HUMANS; INFECTION; INFLAMMATION; INTEGRIN ALPHAVBETA3; MICE; MICE, KNOCKOUT; NEOPLASMS; OLIGOPEPTIDES; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RECEPTORS, SOMATOSTATIN;

EID: 84863801939     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1987-6     Document Type: Review

References (46)

1. Stephenson TJ. Inflammation. In: Underwood JCE, editor. General and systematic pathology. London: Elsevier; 2004. p. 202-20.
2. Boerman OC, Dams ET, Oyen WJ, Corstens FH, Storm G. Radiopharmaceuticals for scintigraphic imaging of infection and inflammation. Inflamm Res. 2001;50:55-64.
3. Rennen HJ, Boerman OC, Oyen WJ, Corstens FH. Imaging infection/ inflammation in the new millennium. Eur J Nucl Med. 2001;28:241-52.
4. Goldsmith SJ, Vallabhajosula S. Clinically proven radiopharmaceuticals for infection imaging: mechanisms and applications. Semin Nucl Med. 2009;39:2-10.
5. Salmi M, Jalkanen S. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Science. 1992;257:1407-9.
6. Salmi M, Tohka S, Berg EL, Butcher EC, Jalkanen S. Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes. J Exp Med. 1997;186:589-600.
7. Jaakkola K, Nikula T, Holopainen R, Vähäsilta T, Matikainen MT, Laukkanen ML, et al. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Am J Pathol. 2000;157:463-71.
8. Salmi M, Kalimo K, Jalkanen S. Induction and function of vascular adhesion protein-1 at sites of inflammation. J Exp Med. 1993;178:2255-60.
9. Marttila-Ichihara F, Smith DJ, Stolen C, Yegutkin GG, Elima K, Mercier N, et al. Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo. Arthritis Rheum. 2006;54:2852-62.
10. Salmi M, Yegutkin GG, Lehvonen R, Koskinen K, Salminen T, Jalkanen S. A cell surface amine oxidase directly controls lymphocyte migration. Immunity. 2001;14:265-76.
11. Madej A, Reich A, Orda A, Szepietowski JC. Vascular adhesion protein-1 (VAP-1) is overexpressed in psoriatic patients. J Eur Acad Dermatol Venereol. 2007;21:72-8.
12. Salmi M, Jalkanen S. VAP-1: an adhesin and an enzyme. Trends Immunol. 2001;22:211-16.
13. Salmi M, Jalkanen S. Cell-surface enzymes in control of leukocyte trafficking. Nat Rev Immunol. 2005;5:760-71.
14. Wakelam MJ, Adams DH. Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion. Hepatology. 2007;45:465-74.
15. Jalkanen S, Karikoski M, Mercier N, Koskinen K, Henttinen T, Elima K, et al. The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding. Blood. 2007;110:1864-70.
16. Lankinen P, Mäkinen TJ, Pöyhönen TA, Virsu P, Salomäki S, Hakanen AJ, et al. (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones. Eur J Nucl Med Mol Imaging. 2008;35:352-64.
17. Ujula T, Salomäki S, Virsu P, Lankinen P, Mäkinen TJ, Autio A, et al. Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis. Nucl Med Biol. 2009;36:631-41.
18. Autio A, Ujula T, Luoto P, Salomäki S, Jalkanen S, Roivainen A. PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide (68)Ga-DOTAVAP-P1: comparison with (18)F-FDG. Eur J Nucl Med Mol Imaging. 2010;37:1918-25.
19. Silvola J, Autio A, Luoto P, Jalkanen S, Roivainen A. Preliminary evaluation of novel 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1. Clin Physiol Funct Imaging. 2010;30:75-8.
20. Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, et al. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood. 2011;118:3725-33.
21. Autio A, Henttinen T, Sipilä HJ, Jalkanen S, Roivainen A. Mini-PEG spacering of VAP-1-targeting 68Ga-DOTAVAP-P1 peptide improves PET imaging of inflammation. EJNMMI Res. 2011;1:10.
22. Yegutkin GG, Salminen T, Koskinen K, Kurtis C, McPherson MJ, Jalkanen S, et al. A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress. Eur J Immunol. 2004;34:2276-85.
23. Stolen CM, Marttila-Ichihara F, Koskinen K, Yegutkin GG, Turja R, Bono P, et al. Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo. Immunity. 2005;22:105-15.
24. Marttila-Ichihara F, Auvinen K, Elima K, Jalkanen S, Salmi M. Vascular adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1+ CD11b+ myeloid cells into tumors. Cancer Res. 2009;69:7875-83.
25. Mäkinen TJ, Lankinen P, Pöyhönen T, Jalava J, Aro HT, Roivainen A. Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus. Eur J Nucl Med Mol Imaging. 2005;32:1259-68.
26. Irjala H, Salmi M, Alanen K, Grénman R, Jalkanen S. Vascular adhesion protein 1 mediates binding of immunotherapeutic effector cells to tumor endothelium. J Immunol. 2001;166:6937-43.
27. Yoong KF, McNab G, Hübscher SG, Adams DH. Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma. J Immunol. 1998;160:3978-88.
28. Danese S, Sans M, de la Motte C, Graziani C, West G, Phillips MH, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology. 2006;130:2060-73.
29. Wilder RL. Integrin αvβ3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis. 2002;61:ii96-9.
30. Cao Q, Cai W, Li ZB, Chen K, He L, Li HC, et al. PET imaging of acute and chronic inflammation in living mice. Eur J Nucl Med Mol Imaging. 2007;34:1832-42.
31. Liu S. Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging. Mol Pharm. 2006;3:472-87.
32. Decristoforo C, Hernandez Gonzalez I, Carlsen J, Rupprich M, Huisman M, Virgolini I, et al. 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of αvβ3 integrin expression. Eur J Nucl Med Mol Imaging. 2008;35:1507-15.
33. Knetsch PA, Petrik M, Griessinger CM, Rangger C, Fani M, Kesenheimer C, et al. [68Ga]NODAGA-RGD for imaging αvβ3 integrin expression. Eur J Nucl Med Mol Imaging. 2011;38:1303-12.
34. Chen W, Bural GG, Torigian DA, Rader DJ, Alavi A. Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging. 2009;36:144-51.
35. Laitinen I, Marjamäki P, Haaparanta M, Savisto N, Laine VJ, Soini SL, et al. Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries. Eur J Nucl Med Mol Imaging. 2006;33:1461-7.
36. Haukkala J, Laitinen I, Luoto P, Iveson P, Wilson I, Karlsen H, et al. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice. Eur J Nucl Med Mol Imaging. 2009;36:2058-67.
37. Ambrosini V, Campana D, Bodei L, Nanni C, Castellucci P, Allegri V, et al. 68Ga-DOTANOC PET/CT clinical impact in patients with neuroendocrine tumors. J Nucl Med. 2010;51:669-73.
38. Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging. 2007;34:982-93.
39. Pettinato C, Sarnelli A, Di Donna M, Civollani S, Nanni C, Montini G, et al. 68Ga-DOTANOC: biodistribution and dosimetry in patients affected by neuroendocrine tumors. Eur J Nucl Med Mol Imaging. 2008;35:72-9.
40. Ambrosini V, Zompatori M, De Luca F, Antonia D, Allegri V, Nanni C, et al. 68Ga-DOTANOC PET/CT allows somatostatin receptor imaging in idiopathic pulmonary fibrosis: preliminary results. J Nucl Med. 2010;51:1950-55.
41. El-Maghraby TA, Moustafa HM, Pauwels EK. Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities. Q J Nucl Med Mol Imaging. 2006;50:167-92.
42. Ehrhardt GJ, Welch MJ. A new germanium-63/gallium-68 generator. J Nucl Med. 1978;19:925-9.
43. Ambrosini V, Nanni C, Zompatori M, Campana D, Tomassetti P, Castellucci P, et al. (68)Ga-DOTA-NOC PET/CT in comparison with CT for the detection of bone metastasis in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2010;37:722-7.
44. Nanni C, Errani C, Boriani L, Fantini L, Ambrosini V, Boschi S, et al. 68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results. J Nucl Med. 2010;51:1932-6.
45. Silvola J, Laitinen I, Sipilä H, Laine VJO, Leppänen P, Ylä-Herttuala S, et al. Uptake of 68gallium in atherosclerotic plaques in LDLR-/- ApoB100/100 mice. EJNMMI Res. 2011;1:14.
46. Petrik M, Haas H, Dobrozemsky G, Lass-Flörl C, Helbok A, Blatzer M, et al. 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med. 2010;51:639-45.