Evaluation of gallium-68 tris(2-mercaptobenzyl) amine: A complex with brain and myocardial uptake

Nuclear Medicine and Biology

Volumn 26, Issue 3, 1999, Pages 305-316

  Cutler, Cathy S ^a   Giron, M Cecilia ^a   Reichert, David E ^a   Snyder, Abraham Z ^a   Herrero, Pilar ^a   Anderson, Carolyn J ^a   Quarless, Duncan A ^b   Koch, Stephen A ^b   Welch, Michael J ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

68Ga S3N; Brain imaging agent; Ga(III); Heart imaging agent; Imaging

Indexed keywords

GALLIUM 68; RADIOLIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; DRUG CLEARANCE; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG UPTAKE; FEMALE; HAMSTER; IMAGING; ISOTOPE LABELING; MALE; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; RADIOISOTOPE DISTRIBUTION; RAT;

ANIMALS; AUTORADIOGRAPHY; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CRICETINAE; DOGS; DRUG STABILITY; ETHANOL; FEMALE; GALLIUM RADIOISOTOPES; HEART; LUNG; MACACA NEMESTRINA; MALE; MESOCRICETUS; MYOCARDIUM; ORGANOMETALLIC COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; THIOSEMICARBAZONES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033119029     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(98)00108-5     Document Type: Article

References (39)

1. Anderson C.J., John C.S., Li Y.J., Hancock R.D., McCarthy T.J., Martell A.E., Welch M.J. N,N′-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III) Molecular modeling, thermodynamic stability and in vivo studies . Nucl. Med. Biol. 22:1995;165-173.
2. Anderson C.J., Welch M.J. Gallium. Seiler H.G., Sigel A., Sigel H. Handbook on metals in clinical and analytical chemistry. 1994;371-380 Marcel Dekker, Inc, Basel, Switzerland.
3. 99mTc complexes . Int. J. Radiat. Appl. Instrum., Part B Nucl. Med. Biol. 16:1989;191-232.
4. Dischino D.D., Welch M.J., Kilbourn M.R., Raichle M.R. Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals. J. Nucl. Med. 24:1983;1031-1038.
5. Eberling J.L., Enas J.D., Budinger T.F. The misidentification of midbrain anatomical structures using neurochemical imaging. J. Nucl. Med. 39:1998;208.
6. Francesconi L.C., Liu B.L., Billings J.J., Carroll P.J., Graczyk G., Kung H.F. Synthesis, characterization and solid state structure of a neutral gallium(III) amino thiolate complex A potential radiopharmaceutical for PET imaging . J. Chem. Soc., Chem. Commun. 2:1991;94-95.
7. Govindaswamy N., Quarless D.A. Jr, Koch S.A. New amine trithiolate tripod ligand and its iron(II) and iron(III) complexes. J. Am. Chem. Soc. 117:1995;8468-8469.
8. Green M.A. Synthesis and biodistribution of a series of lipophilic gallium-67 tris(salicylaldimine) complexes. J. Labelled Compd. Radiopharm. 23:1986;1227-1229.
9. 4-methylthiosemicarbazone) . Nucl. Med. Biol. 14:1987;59-61.
10. Green M.A., Mathias C.J., Neumann W.A., Fanwick P.E., Janik M., Deutsch E.A. Potential gallium-68 tracers for imaging the heart with PET Evaluation of four gallium complexes with functionalized tripodal tris(salicylaldimine) ligands . J. Nucl. Med. 34:1993;228-233.
11. Green M.A., Welch M.J., Mathias C.J., Fox K.A.A., Knabb R.M., Huffman J.C. Gallium-68 1,1,1-tris(5-methoxysalicylaldiminomethyl)ethane A potential tracer for evaluation of regional myocardial blood flow . J. Nucl. Med. 26:1985;170-180.
12. Hack S.N., Eichling J.O., Bergmann S.R., Welch M.J., Sobel B.E. External quantification of myocardial perfusion by exponential infusion of positron-emitting radionuclides. J. Clin. Invest. 66:1980;918-927.
13. Hancock R.D. Macrocycles and their selectivity for metal ions on the basis of size. Pure Appl. Chem. 58:1986;1445-1452.
14. Hancock R.D. Molecular mechanics calculations as a tool in coordination chemistry. Prog. Inorg. Chem. 37:1989;187-291.
15. Hancock R.D. Molecular mechanics calculations and metal ion recognition. Acc. Chem. Res. 23:1990;253-257.
16. Hancock R.D., Reichert D.E., Welch M.J. Molecular mechanics force field for modeling technetium(V) complexes. Inorg. Chem. 35:1996;2165-2166.
17. Harris W.R., Pecoraro V.L. Thermodynamic binding constants for gallium transferrin. Biochemistry. 22:1983;292-299.
18. Hegetschweiler K., Hancock R.D., Ghisletta M., Kradolfer T., Gramlich V., Schmalle H.W. 1,3,5-trideoxy-cis-inosital, a ligand with a remarkable versatility for metal ions. 5. Complex formation with magnesium(II), calcium(II), strontium(II), barium(II) and cadmium(II). Inorg. Chem. 32:1993;5273-5284.
19. Kung H.F., Liu B.-L., Billings J.J., Francesconi L.C., Alavi A. A new myocardial imaging agent Synthesis, characterization and biodistribution of gallium-68-BAT-TECH . J. Nucl. Med. 31:1990;1635-1640.
20. Loc'h C., Maziere B., Comar D. A new generator for ionic gallium-68. J. Nucl. Med. 21:1980;171-173.
21. 2BED A potential generator-produced tracer of myocardial perfusion for positron emission tomography . Int. J. Radiat. Appl. Instrum., Part B Nucl. Med. Biol. 19:1992;431-444.
22. Mathias C.J., Sun Y.Z., Welch M.J., Green M.A., Thomas J.A., Wade K.R., Martell A.R. Targeting radiopharmaceuticals Comparative biodistribution studies of gallium and indium complexes of multidentate ligands . Int. J. Radiat. Appl. Instrum., Part B Nucl. Med. Biol. 15:1988;69-81.
23. Matsumoto K., Fujibayashi Y., Yonekura Y., Wada K., Takemura Y., Konishi J., Yokoyama A. Application of the zinc-62/copper-62 generator An effective labeling method for Cu-62-PTSM . Nucl. Med. Biol. 19:1992;39-44.
24. Mazoyer B., Trebossen R., Deutch R., Casey M., Blohm K. Physical characteristics of the ECAT 953B/31 A new high resolution brain positron tomograph . IEEE Trans. Med. Imag. 10:1991;499-504.
25. 64Cu using a biomedical cyclotron. Nucl. Med. Biol. 24:1997;35-43.
26. McCarthy T.J., Sherman E.L.C., Talley J.J., Seibert K., Isakson P.C., Welch M.J. Radiosynthesis, biodistribution and PET imaging of potent and selective inhibitors of cyclooxygenase-1 and cyclooxygenase-2. J. Nucl. Med. 36:1995;49P.
27. Motekaitis R.J., Martell A.E., Koch S.A., Hwang J.W., Quarless D.A., Welch M.J. The gallium (III) and indium(III) complexes of tris(2-mercaptobenzyl)amine and tris(2-hydroxybenzyl)amine. Inorg Chem. 37:1998;5902-5911.
28. Reichert D.E., Hancock R.D., Welch M.J. Molecular mechanics investigation of gadolinium(III) complexes. Inorg. Chem. 35:1996;7013-7020.
29. Shannon R.D. Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Acta Crystallogr., Sect. A: Found. Crystallogr. 32:1976;751-767.
30. Shelton M.E., Green M.A., Mathias C.J., Welch M.J., Bergmann S.R. Kinetics of copper-PTSM in isolated hearts A novel tracer for measuring blood flow with positron emission tomography . J. Nucl. Med. 30:1989;1843-1847.
31. Shelton M.E., Green M.A., Mathias C.J., Welch M.J., Bergmann S.R. Assessment of regional myocardial and renal blood flow with copper-PTSM and positron emission tomography. Circulation. 82:1990;990-997.
32. Spinks T., Jones T., Bailey D., Townsend D., Grootoonk S., Bloomfield P., Gilardi M., Casey M., Sipe B., Reed J. Physical performance of positron tomograph for brain imaging with retractable septa. Phys. Med. Biol. 37:1993;1637-1655.
33. Spinks T.J., Jones T., Gilardi M.C., Heather J.D. Physical performance of the latest generation of commercial positron scanner. IEEE Trans. Nucl. Sci. 35:1988;721-725.
34. Sun Y., Anderson C.J., Pajeau T.S., Reichert D.E., Hancock R.D., Motekaitis R.J., Martell A.E., Welch M.J. Indium (III) and Gallium(III) complexes of bis(aminoethanethiol) ligands with different denticities Stabilities, molecular modeling and in vivo behavior . J. Med. Chem. 39:1996;458-470.
35. Thöm V., Fox C.C., Boeyens J.C.A., Hancock R.D. Molecular mechanics and crystallographic study of hole sizes in nitrogen-donor tetraaza macrocycles. J. Am. Chem. Soc. 106:1984;5947-5955.
36. Tsang B.W., Mathias C.J., Fanwick P.E., Green M.A. Structure-distribution relationships for metal-labeled myocardial imaging agents Comparison of a series of cationic gallium(III) complexes with hexadentate bis(salicylaldimine) ligands . J. Med. Chem. 37:1994;4400-4406.
37. + . J. Nucl. Med. 34:1993;1127-1131.
38. Tripos SYBYL, 6.2 ed. (1995) Tripos Inc., St. Louis, MO.
39. 67Ga radiopharmaceuticals for myocardial imaging Tris(1-aryl-3-hydroxy-2-methyl-4-pyridinato)gallium(III) complexes . Nucl. Med. Biol. 19:1992;327-335.