Can long range mechanical interaction between drugs and membrane proteins define the notion of molecular promiscuity? Application to P-glycoprotein- mediated multidrug resistance (MDR)

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 11, 2013, Pages 5112-5118

  Rauch, Cyril ^a   Paine, Stuart W ^a   Littlewood, Peter ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

Cancer; Drug toxicity and adverse effect; Membrane mechanical property; Molecular promiscuity; Multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DRUG; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; MATHEMATICAL MODEL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MULTIDRUG RESISTANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN STRUCTURE;

CANCER; DRUG TOXICITY AND ADVERSE EFFECT; MEMBRANE MECHANICAL PROPERTY; MOLECULAR PROMISCUITY; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; LIPID METABOLISM; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; P-GLYCOPROTEIN;

EID: 84881518289     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.06.038     Document Type: Article

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