P-glycoprotein-ATPase modulation: The molecular mechanisms

Biophysical Journal

Volumn 102, Issue 6, 2012, Pages 1383-1393

  Li Blatter, Xiaochun ^a   Beck, Andreas ^a   Seelig, Anna ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; DETERGENT; GLYCOPROTEIN P; LIPID; LIPOSOME;

AIR; ANIMAL; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; KINETICS; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THERMODYNAMICS;

ADENOSINE TRIPHOSPHATASES; AIR; ANIMALS; CELL MEMBRANE; DETERGENTS; KINETICS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, MOLECULAR; P-GLYCOPROTEIN; THERMODYNAMICS; UNILAMELLAR LIPOSOMES;

EID: 84858780436     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.02.018     Document Type: Article

References (39)

1. C.F. Higgins, and M.M. Gottesman Is the multidrug transporter a flippase? Trends Biochem. Sci. 17 1992 18 21
2. J.K. Zolnerciks, and E.J. Andress K.J. Linton Structure of ABC transporters Essays Biochem. 50 2011 43 61
3. S.V. Ambudkar, and C.O. Cardarelli W.D. Stein Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein J. Biol. Chem. 272 1997 21160 21166 (Pubitemid 27373976)
4. H. Omote, and M.K. Al-Shawi A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein J. Biol. Chem. 277 2002 45688 45694 (Pubitemid 36159181)
5. M.K. Al-Shawi, and H. Omote The remarkable transport mechanism of P-glycoprotein: a multidrug transporter J. Bioenerg. Biomembr. 37 2005 489 496 (Pubitemid 43725181)
6. A. Seelig The role of size and charge for blood-brain barrier permeation of drugs and fatty acids J. Mol. Neurosci. 33 2007 32 41 (Pubitemid 47574956)
7. P. Nervi, and X. Li-Blatter A. Seelig P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity Biochim. Biophys. Acta 1798 2010 515 525
8. A. Seelig Toward understanding P-glycoprotein structure-activity relationships H. van de Waterbeemd, B. Testa, Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability 2nd ed. 2009 Wiley Weinheim, Germany 497 520
9. P. Aanismaa, and A. Seelig P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells Biochemistry 46 2007 3394 3404 (Pubitemid 46449158)
10. X. Li-Blatter, P. Nervi, and A. Seelig Detergents as intrinsic P-glycoprotein substrates and inhibitors Biochim. Biophys. Acta 1788 2009 2335 2344
11. X. Li-Blatter, and A. Seelig Exploring the P-glycoprotein binding cavity with polyoxyethylene alkyl ethers Biophys. J. 99 2010 3589 3598
12. C.A. Doige, X. Yu, and F.J. Sharom The effects of lipids and detergents on ATPase-active P-glycoprotein Biochim. Biophys. Acta 1146 1993 65 72 (Pubitemid 23067043)
13. R. Callaghan, and G. Berridge C.F. Higgins The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface Biochim. Biophys. Acta 1328 1997 109 124 (Pubitemid 27376440)
14. S. Orlowski, and M.A. Selosse M. Garrigos Effects of detergents on P-glycoprotein atpase activity: differences in perturbations of basal and verapamil-dependent activities Cancer Biochem. Biophys. 16 1998 85 110
15. S.V. Ambudkar, and S. Dey M.M. Gottesman Biochemical, cellular, and pharmacological aspects of the multidrug transporter Annu. Rev. Pharmacol. Toxicol. 39 1999 361 398 (Pubitemid 29222564)
16. A. Seelig, and G. Gerebtzoff Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding Expert Opin. Drug Metab. Toxicol. 2 2006 733 752 (Pubitemid 46118318)
17. E. Gatlik-Landwojtowicz, P. Aanismaa, and A. Seelig Quantification and characterization of P-glycoprotein-substrate interactions Biochemistry 45 2006 3020 3032 (Pubitemid 43334550)
18. J. Seelig, and A. Seelig Lipid conformation in model membranes and biological membranes Q. Rev. Biophys. 13 1980 19 61
19. N. Akhtar, and A. Ahad S. Talegaonkar The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review Expert Opin Ther Pat. 21 2011 561 576
20. T. Litman, and T. Zeuthen W.D. Stein Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity Biochim. Biophys. Acta 1361 1997 159 168 (Pubitemid 27362089)
21. P. Fromherz Instrumentation for handling monomolecular films at an air-water interface Rev. Sci. Instrum. 46 1975 1380 1385
22. H. Fischer, R. Gottschlich, and A. Seelig Blood-brain barrier permeation: molecular parameters governing passive diffusion J. Membr. Biol. 165 1998 201 211 (Pubitemid 28465226)
23. G. Gerebtzoff, and X. Li-Blatter A. Seelig Halogenation of drugs enhances membrane binding and permeation ChemBioChem 5 2004 676 684 (Pubitemid 39257090)
24. A. Beck, and X. Li-Blatter J. Seelig On the interaction of ionic detergents with lipid membranes. Thermodynamic comparison of n-alkyl-+N(CH) and n-alkyl-SO J. Phys. Chem. B 114 2010 15862 15871
25. H. Heerklotz, and J. Seelig Correlation of membrane/water partition coefficients of detergents with the critical micelle concentration Biophys. J. 78 2000 2435 2440 (Pubitemid 30313801)
26. A. Seelig, and E. Landwojtowicz X. Li Blatter Towards P-glycoprotein structure-activity relationships Drug Bioavailability. Estimation of Solubility, Permeability and Absorption 2003 Wiley/VCH Weinheim, Germany 461 492
27. A. Seelig, and E. Landwojtowicz Structure-activity relationship of P-glycoprotein substrates and modifiers Eur. J. Pharm. Sci. 12 2000 31 40
28. A. Seelig Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers Biochim. Biophys. Acta 899 1987 196 204 (Pubitemid 17086618)
29. V. Boguslavsky, and M. Rebecchi S. McLaughlin Effect of monolayer surface pressure on the activities of phosphoinositide-specific phospholipase C-β1, -γ1, and -δ1 Biochemistry 33 1994 3032 3037 (Pubitemid 24103365)
30. M. Meier, and J. Seelig Lipid and peptide dynamics in membranes upon insertion of n-alkyl-β-D-glucopyranosides Biophys. J. 98 2010 1529 1538
31. J. Seelig, and P. Ganz Nonclassical hydrophobic effect in membrane binding equilibria Biochemistry 30 1991 9354 9359
32. G. Beschiaschvili, and J. Seelig Peptide binding to lipid bilayers. Nonclassical hydrophobic effect and membrane-induced pK shifts Biochemistry 31 1992 10044 10053
33. M.R. Wenk, and T. Alt J. Seelig Octyl-β-D-glucopyranoside partitioning into lipid bilayers: thermodynamics of binding and structural changes of the bilayer Biophys. J. 72 1997 1719 1731 (Pubitemid 27133111)
34. M. Meier, and X.L. Blatter J. Seelig Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity Biophys. J. 91 2006 2943 2955 (Pubitemid 44526485)
35. P. Aanismaa, E. Gatlik-Landwojtowicz, and A. Seelig P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle Biochemistry 47 2008 10197 10207
36. Z.E. Sauna, and M.B. Andrus S.V. Ambudkar Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy Biochemistry 43 2004 2262 2271 (Pubitemid 38279971)
37. M.K. Gannon 2nd, and J.J. Holt Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity J. Med. Chem. 52 2009 3328 3341
38. H. Heerklotz Interactions of surfactants with lipid membranes Q. Rev. Biophys. 41 2008 205 264
39. M.R. Wenk, and J. Seelig Interaction of octyl-β-thioglucopyranoside with lipid membranes Biophys. J. 73 1997 2565 2574