Real-time analysis of quercetin, resveratrol and/or doxorubicin effects in mcf-7 cells

Romanian Biotechnological Letters

Volumn 18, Issue 2, 2013, Pages 8106-8114

  Mihaila, Mirela ^a   Bostan, Marinela ^b   Hotnog, Dan ^b   Ferdes, Mariana ^a   Brasoveanu, Lorelei I ^b  

^a UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^b STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Cytotoxicity; Doxorubicin; Quercetin; Resveratrol; RTCA; XCELLigence

Indexed keywords

EID: 84881513659     PISSN: 12245984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. M.J. ELLIS, D.F. HAZES, M.E. LUIPPMAN, Treatment of metastatic breast cancer, in Diseases of Breast, Ed: J.R. HARRIS, M.E. LIPPMAN, M. MORROW M., C.K. OSBORNE, Philadelphia: Lippincott-Raven (2000).
2. A. JEMAL, R. SIEGEL, E. WARD, Y. HAO, J. XU, T. MURRAY, Cancer statistics. CA-Cancer J. Clin., 58, 71-96 (2008)
3. B. DESOIZE, J. JARDILLIER, Multicellular resistance: a paradigm for clinical resistance? Crit. Rev. Oncol. Hematol., 36,2-3,193-207 (2000).
4. M.M. GOTTESMAN, Mechanisms of cancer drug resistance. Annu Rev Med, 53,615-627 (2002).
5. J. MATTERN, Drug resistance in cancer: a multifactorial problem. Anticancer Res, 23,2C,1769-1772 (2003).
6. H.S. AIYER, A.M. WARRI, D.R. WOODE, L.H. CLARKE, R. CLARKE, Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. J. Agric. Food Chem., 60, 5693-5708 (2012).
7. T. SAKAMOTO, H. HORIGUCHI, E. OGUMA, F. KAYAMA, Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. J Nutr Biochem., 21(9), 856-864 (2010).
8. S. FULDA, Modulation of apoptosis by natural products for cancer therapy. Planta Med., 76, 1075-1079 (2010).
9. G. DU, H. LIN, Y. YANG, S. ZHANG, X. WU, M. WANG, L. JI, L. LU, L. YU, G. HAN, Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice. Int Immunopharmacol., 10(7), 819-826 (2010).
10. M.K. SHANMUGAMA, R. KANNAIYANA & G. SETHI, Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer. Nutr. and Cancer, 63, 1075-1079 (2011).
11. H. ZHANG, M. ZHANG, L. YU, Y. ZHAO, N. HE, X. YANG, Antitumor activities of quercetin and quercetin-50, 8-disulfonate in human colon and breast cancer cell lines. Food Chem. Toxicol., 50, 1589-1599 (2012).
12. K.C. ZIMMERMANN, C. BONZON, D.R. GREEN, The machinery of programmed cell death. Pharmacol. Ther., 92,1,57-70 (2001).
13. R. KIM, K. TANABE, Y. UCHIDA, M. EMI, H. INOUE, T. TOGE, Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother. Pharmacol., 50,5,343-352 (2002).
14. S.H. KAUFMANN, D.L. VAUX Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene, 22,47,7414-7430 (2003).
15. T.C. HSIEH, C. WONG, D.J. BENNETT, J.M. WU, Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin avß3. Int. J. Cancer, 129(11), 2732-2743 (2011).
16. L. CASTILLO-PICHARDO AND S.F. DHARMAWARDHANE, Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr. and Cancer, 64(7), 1058-1069 (2012).
17. H.S. SEO, J. JU, K. JANG, I. SHIN, Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor a-negative breast cells. Nutr. Res., 31, 139-146 (2011).
18. J.H. JEONG, J.Y. AN, Y.T KWON, J.G. RHEE, Y.J. LEE, Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression. J. Cell. Biochem., 106, 73-82 (2009).
19. C.C. CHOU, J.S. YANG, H.F. LU, S.W. IP, C. LO, C.C. WU, J.P. LIN, N.Y. TANG, J.G. CHUNG, M.J CHOU, Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch. Pharm. Res., 33(8), 1181-1191 (2010).
20. Y.K. LEE, O.J. PARK, Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells. Oncol. Report, 24, 1493-1497, (2010).
21. C.H. COTTART, V.N. ANTOINE, C.L. MORIZOT, J.L. BEAUDEUX, Resveratrol bioavailability and toxicity in humans. Mol. Nutr. & Food Res., 54, 7-16 (2010).
22. C. ZHANG, G. LIN, W. WAN, X. LI, B. ZENG, B. YANG AND C. HUANG, Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-kB signaling pathway. Int. J. Mol. Med., 29(4), 557-563 (2012).
23. C. CAL, H. GARBAN, A. JAZIREHI, C. YEH, Y. MIZUTANI AND B. BONAVIDA, Resveratrol and cancer: chemoprevention, apoptosis, and chemoimmunosensitizing activities. Curr. Med. Chem. - Anti-Cancer Agents, 3, 77-93 (2003).
24. G. FILOMENI, I. GRAZIANI, G. ROTILIO, M.R. CIRIOLO, Trans-resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways. Genes Nutr. 2(3), 295-305 (2007).
25. A. SKLADANOWSKI, J. KONOPA, Adriamycin and daunorubyacininduce programmed cell death (apoptosis) in tumour cells. Biochem. Pharmacol., 46,3,375-382 (1993).
26. G. DU, H. LIN, M. WANG, S. ZHANG, X. WU, L. LU, L. JI, L. YU, Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1a in tumor and normal cells. Cancer Chemother. Pharmacol., 65(2), 277-287 (2010).
27. N. SINGH, M. NIGAM, V. RANJAN, D. ZAIDI, V.K. GARG, S. SHARMA, R. CHATURVEDI, R. SHANKAR, S. KUMAR, R. SHARMA, K. MITRA, A.K. BALAPURE, S.K. RATH, Resveratrol as an adjunct therapy in cyclophosphamide-treated MCF-7 cells and breast tumor explants. Cancer Sci., 102(5), 1059-1067 (2011).
28. P.D. SANCHEZ-GONZALEZ, F.LOPEZ-HERNANDEZ, F.P. BARRIOCANAL, A.I. MORALES, J.M.L. NOVOA, Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol. Dial. Transplant., 26, 3484-3495 (2011).
29. D. STAEDLER, E. IDRIZI, B.H. KENZAOUI, L.J. JEANNERET, Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Cancer Chemother. Pharmacol., 68, 1161-1172 (2011).
30. A.M. OSMAN, H.M. BAYOUMI, S.E. AL-HARTHI, Z.A. DAMANHOURI, M.F. ELSHAL, Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell line. Cancer Cell Int., 12(1), 47 (2012).
31. C. KNOP, J. PUTNIK, M. SCHEUERMANN, M. SCHMITZ, Cutting Edge Technologies: Cell Analysis/ 2010, B. Ziebolz, ed., Springer Medizin, Springer Verlag, Heidelberg, Germany, 2010, pp. 4-13, 58-68, 137-141.
32. F. CASANOVA, J. QUARTI, D.C. DA COSTA, C.A. RAMOS, J.L. DA SILVA, E. FIALHO, Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest. J. Cell. Biochem., 113(8), 2586-2596 (2012).
33. G. SCAMBIA, F.O. RANELLETTI, P.B. PANICI, R. DE VINCENZO, G. BONANNO, G. FERRANDINA, M. PIANTELLI, S. BUSSA, C. RUMI, M. CIANFRIGLIA, Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancercell line: P-glycoprotein as a possible target. Cancer Chemother. Pharmacol., 34(6), 459-464 (1994).