Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest

Journal of Cellular Biochemistry

Volumn 113, Issue 8, 2012, Pages 2586-2596

  Casanova, Fabiana ^a   Quarti, Julia ^a   Ferraz Da Costa, Danielly Cristiny ^a   Ramos, Caroline Araújo ^a   Da Silva, Jerson Lima ^a   Fialho, Eliane ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Apoptosis; Cancer; Cell cycle; Melphalan; Resveratrol

Indexed keywords

CASPASE 7; CASPASE 9; CHECKPOINT KINASE 2; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; MELPHALAN; PROCASPASE 8; PROTEIN P53; RESVERATROL; THREONINE;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL VIABILITY; CHEMOSENSITIZATION; CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; IMMUNOPRECIPITATION; MELPHALAN; STILBENES;

EID: 84862555961     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24134     Document Type: Article

References (38)

1. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. 2004. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia 6:646-659. (Pubitemid 39411101)
2. Ahmad KA, Clement MV, Hanif IM, Pervaiz S. 2004. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res 64:1452-1459. (Pubitemid 38235616)
3. Ahn J, Urist M, Prives C. 2004. The Chk2 protein kinase. DNA Repair 3:1039-1047. (Pubitemid 38997946)
4. Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL. 2009. Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 486:95-102.
5. Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N. 2006. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 5:1335-1341. (Pubitemid 43881327)
6. Baur JA, Sinclair DA. 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 5:493-506. (Pubitemid 44136961)
7. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shishodia S, Aggarwal BB. 2007. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-kappa B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109: 2293-2302. (Pubitemid 46425866)
8. Carmichael J, Degraff W, Gazdar A, Minna J, Mitchell J. 1987. Evaluation of a tetrazolinium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res 47:936-942. (Pubitemid 17027905)
9. Chan JY, Phoo MS, Clement MV, Pervaiz S, Lee SC. 2008. Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis-The roles of caspase-6 and p53. Cancer Biol Ther 7:1305-1312.
10. Dollery C. 1991. Melphalan, therapeutic drugs. London: Churchill Livingstone.
11. Dotto GP. 2000. p21 WAF1/Cip1: More than a break to the cell cycle? Biochim Biophys Acta 1471:M43-M56.
12. Duraj J, Bodo J, Sulikova M, Rauko P, Sedlak J. 2006. Diverse resveratrol sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells. Neoplasma 53:384-392. (Pubitemid 44689851)
13. Fulda S, Debatin KM. 2004. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 23:6702-6711. (Pubitemid 39280002)
14. Garg AK, Buchholz TA, Aggarwal BB. 2005. Chemosensitization and radio-sensitization of tumors by plant polyphenols. Antioxid Redox Signal 7: 1630-1647. (Pubitemid 41767998)
15. Gatouillat G, Balasse E, Joseph-Pietras D, Morjani H, Madoulet C. 2010. Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma. J Cell Biochem 110:893-902.
16. Goswami SK, Das DK. 2009. Resveratrol and chemoprevention. Cancer Lett 284:1-6.
17. Gupta SC, Kannappan R, Reuter S, Kim JH, Aggarwal BB. 2011. Chemosensitization of tumors by resveratrol. Ann NY Acad Sci 1215:150-160.
18. Gusman J, Malonne H, Atassi G. 2001. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 22:1111-1117. (Pubitemid 32737324)
19. He X, Wang Y, Zhu JH, Orloff M, Eng C. 2011. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett 301:168-176.
20. Higgins CF. 2007. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446:749-757. (Pubitemid 46582024)
21. Jang MS, Cai EN, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218-220. (Pubitemid 127696281)
22. Jazirehi AR, Bonavida B. 2004. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 3:71-84. (Pubitemid 39193680)
23. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. 2011. Global Cancer Statistics. CA Cancer J Clin 61:69-90.
24. Kaldis P, Aleem E. 2005. Cell cycle sibling rivalry-Cdc2 vs. Cdk2. Cell Cycle 4:1491-1494.
25. Kubota T, Uemura Y, Kobayashi M, Taguchi H. 2003. Combined effects of resveratrol and paclitaxel on lung cancer cells. Anticancer Res 23:4039-4046. (Pubitemid 37474362)
26. Liang YC, Tsai SH, Chen L, Lin-Shiau SY, Lin JK. 2003. Resveratrol-induced G(2) arrest through the inhibition of CDK7 and p34(CDC2) kinases in colon carcinoma HT29 cells. Biochem Pharmacol 65:1053-1060. (Pubitemid 36349745)
27. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
28. Malumbres M, Barbacid M. 2005. Mammalian cyclin-dependent kinases. Trends Biochem Sci 30:630-641. (Pubitemid 41540083)
29. Mao QQ, Bai Y, Lin YW, Zheng XY, Qin J, Yang K, Xie LP. 2010. Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines. Mol Nutr Food Res 54:1574-1584.
30. Marques FZ, Markus MA, Morris BJ. 2009. Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol 41:2125-2128.
31. Nakagawa H, Kiyozuka Y, Uemura Y, Senzaki H, Shikata N, Hioki K, Tsubura A. 2001. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol 127:258-264.
32. Pozo-Guisado E, Alvarez-Barrientos A, Mulero-Navarro S, Santiago-Josefat B, Fernandez-Salguero PM. 2002. The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: Cell-specific alteration of the cell cycle. Biochem Pharmacol 64:1375-1386. (Pubitemid 35248254)
33. Rothbarth J, Koevoets C, Tollenaar R, Tilby MJ, van de Velde CJH, Mulder GJ, Kuppen PJK. 2004. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol 67:1771-1778. (Pubitemid 38479855)
34. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R. 2008. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ 15:1318-1329. (Pubitemid 351984760)
35. Vermeulen K, Van Bockstaele DR, Berneman ZN. 2003. The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 36:131-149. (Pubitemid 36808270)
36. Wesierska-Gadek J, Kramer MP, Maurer M. 2008. Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells. Food Chem Toxicol 46:1327-1333. (Pubitemid 351258203)
37. Woo RA, Poon RY. 2003. Cyclin-dependent kinases and S phase control in mammalian cells. Cell Cycle 2:316-324.
38. Zhou R, Fukui M, Choi HJ, Zhu BT. 2009. Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection. Br J Pharmacol 158:462-474.