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Volumn 43, Issue 10, 2013, Pages 1115-1123

Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment

Author keywords

Alcoholic liver disease; Chlormethiazole; Cytochrome P4502E1; Kupffer cell; Lipopolysaccharide; Nuclear factor B

Indexed keywords

ALCOHOL; CLOMETHIAZOLE; CYTOCHROME P450 2E1; I KAPPA B ALPHA; LIPOPOLYSACCHARIDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84881506662     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12063     Document Type: Article
Times cited : (23)

References (48)
  • 2
    • 78149386734 scopus 로고    scopus 로고
    • Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets
    • Severi T, van Malenstein H, Verslype C, van Pelt JF. Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta Pharmacol Sin 2010; 31: 1409-1420.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1409-1420
    • Severi, T.1    van Malenstein, H.2    van Verslype, C.3    Pelt, J.F.4
  • 3
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis and new therapeutic targets
    • Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011; 141: 1572-1585.
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 4
    • 0030935567 scopus 로고    scopus 로고
    • Cytochrome P-4502E1: its physiological and pathological role
    • Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 1997; 77: 517-544.
    • (1997) Physiol Rev , vol.77 , pp. 517-544
    • Lieber, C.S.1
  • 5
    • 33845953191 scopus 로고    scopus 로고
    • The 2006 Bernard B. Brodie Award Lecture. Cyp2e1
    • Gonzalez FJ. The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug Metab Dispos 2007; 35: 1-8.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1-8
    • Gonzalez, F.J.1
  • 6
    • 33746329952 scopus 로고    scopus 로고
    • CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury
    • Cederbaum AI. CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med 2006; 73: 657-672.
    • (2006) Mt Sinai J Med , vol.73 , pp. 657-672
    • Cederbaum, A.I.1
  • 7
    • 39149123560 scopus 로고    scopus 로고
    • CYP2E1 and oxidative liver injury by alcohol
    • Lu Y, Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 2008; 44: 723-738.
    • (2008) Free Radic Biol Med , vol.44 , pp. 723-738
    • Lu, Y.1    Cederbaum, A.I.2
  • 8
    • 0036298103 scopus 로고    scopus 로고
    • Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage
    • Morgan K, French SW, Morgan TR. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology 2002; 36: 122-134.
    • (2002) Hepatology , vol.36 , pp. 122-134
    • Morgan, K.1    French, S.W.2    Morgan, T.R.3
  • 9
    • 33747099988 scopus 로고    scopus 로고
    • CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury
    • Jimenez-Lopez JM, Cederbaum AI. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opin Drug Metab Toxicol 2005; 1: 671-685.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 671-685
    • Jimenez-Lopez, J.M.1    Cederbaum, A.I.2
  • 10
    • 0028233907 scopus 로고
    • Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
    • Hu Y, Mishin V, Johansson I etal. Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. J Pharmacol Exp Ther 1994; 269: 1286-1291.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 1286-1291
    • Hu, Y.1    Mishin, V.2    Johansson, I.3
  • 11
    • 0030815178 scopus 로고    scopus 로고
    • Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans
    • Gebhardt AC, Lucas D, Menez JF, Seitz HK. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology 1997; 26: 957-961.
    • (1997) Hepatology , vol.26 , pp. 957-961
    • Gebhardt, A.C.1    Lucas, D.2    Menez, J.F.3    Seitz, H.K.4
  • 12
    • 0029619580 scopus 로고
    • The management of alcohol withdrawal using chlormethiazole
    • Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol Alcohol 1995; 30: 771-774.
    • (1995) Alcohol Alcohol , vol.30 , pp. 771-774
    • Morgan, M.Y.1
  • 13
    • 0025752258 scopus 로고
    • Chlormethiazole: current status in the treatment of the acute ethanol withdrawal syndrome
    • Majumdar SK. Chlormethiazole: current status in the treatment of the acute ethanol withdrawal syndrome. Drug Alcohol Depend 1991; 27: 201-207.
    • (1991) Drug Alcohol Depend , vol.27 , pp. 201-207
    • Majumdar, S.K.1
  • 14
    • 0033872080 scopus 로고    scopus 로고
    • Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
    • Gouillon Z, Lucas D, Li J etal. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med 2000; 224: 302-308.
    • (2000) Proc Soc Exp Biol Med , vol.224 , pp. 302-308
    • Gouillon, Z.1    Lucas, D.2    Li, J.3
  • 15
    • 0036861119 scopus 로고    scopus 로고
    • Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats
    • Liu C, Chung J, Seitz HK, Russell RM, Wang XD. Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats. Alcohol Clin Exp Res 2002; 26: 1703-1709.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1703-1709
    • Liu, C.1    Chung, J.2    Seitz, H.K.3    Russell, R.M.4    Wang, X.D.5
  • 16
    • 43949086592 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    • Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 2008; 47: 1483-1494.
    • (2008) Hepatology , vol.47 , pp. 1483-1494
    • Lu, Y.1    Zhuge, J.2    Wang, X.3    Bai, J.4    Cederbaum, A.I.5
  • 18
    • 33747589667 scopus 로고    scopus 로고
    • Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression
    • Barve S, Joshi-Barve S, Song Z etal. Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression. J Gastroenterol Hepatol 2006; 21 (Suppl 3): S38-42.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Barve, S.1    Joshi-Barve, S.2    Song, Z.3
  • 19
    • 0034095445 scopus 로고    scopus 로고
    • Impact of alcohol on the ability of Kupffer cells to produce chemokines and its role in alcoholic liver disease
    • Bautista AP. Impact of alcohol on the ability of Kupffer cells to produce chemokines and its role in alcoholic liver disease. J Gastroenterol Hepatol 2000; 15: 349-356.
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 349-356
    • Bautista, A.P.1
  • 20
    • 16544370740 scopus 로고    scopus 로고
    • Cytokines-central factors in alcoholic liver disease
    • Neuman MG. Cytokines-central factors in alcoholic liver disease. Alcohol Res Health 2003; 27: 307-316.
    • (2003) Alcohol Res Health , vol.27 , pp. 307-316
    • Neuman, M.G.1
  • 21
    • 77950825001 scopus 로고    scopus 로고
    • Alcoholic liver disease and the gut-liver axis
    • Szabo G, Bala S. Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 2010; 16: 1321-1329.
    • (2010) World J Gastroenterol , vol.16 , pp. 1321-1329
    • Szabo, G.1    Bala, S.2
  • 22
    • 0034985109 scopus 로고    scopus 로고
    • Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin
    • Enomoto N, Ikejima K, Yamashina S etal. Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res 2001; 25: 51S-54.
    • (2001) Alcohol Clin Exp Res , vol.25
    • Enomoto, N.1    Ikejima, K.2    Yamashina, S.3
  • 23
    • 16544368662 scopus 로고    scopus 로고
    • Endotoxin and Kupffer cell activation in alcoholic liver disease
    • Wheeler MD. Endotoxin and Kupffer cell activation in alcoholic liver disease. Alcohol Res Health 2003; 27: 300-306.
    • (2003) Alcohol Res Health , vol.27 , pp. 300-306
    • Wheeler, M.D.1
  • 24
    • 77955982799 scopus 로고    scopus 로고
    • CYP2E1 potentiation of LPS and TNFalpha-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction
    • Lu Y, Cederbaum AI. CYP2E1 potentiation of LPS and TNFalpha-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes Nutr 2010; 5: 149-167.
    • (2010) Genes Nutr , vol.5 , pp. 149-167
    • Lu, Y.1    Cederbaum, A.I.2
  • 26
    • 0036294518 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB
    • Cao Q, Mak KM, Lieber CS. Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB. Biochem Biophys Res Commun 2002; 294: 849-853.
    • (2002) Biochem Biophys Res Commun , vol.294 , pp. 849-853
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 27
    • 0036434601 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats
    • Cao Q, Mak KM, Lieber CS. Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats. Biochem Biophys Res Commun 2002; 299: 459-464.
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 459-464
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 28
    • 0018418116 scopus 로고
    • Isolation and characterization of hepatocytes and Kupffer cells
    • Page DT, Garvey JS. Isolation and characterization of hepatocytes and Kupffer cells. J Immunol Methods 1979; 27: 159-173.
    • (1979) J Immunol Methods , vol.27 , pp. 159-173
    • Page, D.T.1    Garvey, J.S.2
  • 29
    • 34547800757 scopus 로고    scopus 로고
    • Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo
    • Lian F, Smith DE, Ernst H, Russell RM, Wang XD. Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 2007; 28: 1567-1574.
    • (2007) Carcinogenesis , vol.28 , pp. 1567-1574
    • Lian, F.1    Smith, D.E.2    Ernst, H.3    Russell, R.M.4    Wang, X.D.5
  • 30
    • 33745728937 scopus 로고    scopus 로고
    • Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model
    • Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang XD. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis 2006; 27: 1410-1419.
    • (2006) Carcinogenesis , vol.27 , pp. 1410-1419
    • Kim, Y.1    Chongviriyaphan, N.2    Liu, C.3    Russell, R.M.4    Wang, X.D.5
  • 31
    • 47649120373 scopus 로고    scopus 로고
    • Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages
    • Wang Q, Xia M, Liu C etal. Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages. Life Sci 2008; 83: 176-184.
    • (2008) Life Sci , vol.83 , pp. 176-184
    • Wang, Q.1    Xia, M.2    Liu, C.3
  • 32
    • 39749188825 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation
    • Guo H, Ling W, Wang Q, Liu C, Hu Y, Xia M. Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. Biochem Pharmacol 2008; 75: 1393-1401.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1393-1401
    • Guo, H.1    Ling, W.2    Wang, Q.3    Liu, C.4    Hu, Y.5    Xia, M.6
  • 33
    • 0035893937 scopus 로고    scopus 로고
    • The role of Kupffer cell oxidant production in early ethanol-induced liver disease
    • Wheeler MD, Kono H, Yin M etal. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med 2001; 31: 1544-1549.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1544-1549
    • Wheeler, M.D.1    Kono, H.2    Yin, M.3
  • 34
    • 33644527617 scopus 로고    scopus 로고
    • Alcohol and oxidative liver injury
    • Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 2006; 43: S63-74.
    • (2006) Hepatology , vol.43
    • Dey, A.1    Cederbaum, A.I.2
  • 35
    • 0030045690 scopus 로고    scopus 로고
    • Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol
    • Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 1996; 23: 155-163.
    • (1996) Hepatology , vol.23 , pp. 155-163
    • Albano, E.1    Clot, P.2    Morimoto, M.3    Tomasi, A.4    Ingelman-Sundberg, M.5    French, S.W.6
  • 36
    • 0027745582 scopus 로고
    • Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis
    • Morimoto M, Hagbjork AL, Nanji AA etal. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 1993; 10: 459-464.
    • (1993) Alcohol , vol.10 , pp. 459-464
    • Morimoto, M.1    Hagbjork, A.L.2    Nanji, A.A.3
  • 37
    • 0029016297 scopus 로고
    • Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors
    • Morimoto M, Hagbjork AL, Wan YJ etal. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology 1995; 21: 1610-1617.
    • (1995) Hepatology , vol.21 , pp. 1610-1617
    • Morimoto, M.1    Hagbjork, A.L.2    Wan, Y.J.3
  • 38
    • 33644790212 scopus 로고    scopus 로고
    • Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
    • Gong P, Cederbaum AI. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 2006; 43: 144-153.
    • (2006) Hepatology , vol.43 , pp. 144-153
    • Gong, P.1    Cederbaum, A.I.2
  • 39
    • 0033370831 scopus 로고    scopus 로고
    • CYP2E1 is not involved in early alcohol-induced liver injury
    • Kono H, Bradford BU, Yin M etal. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol 1999; 277: G1259-1267.
    • (1999) Am J Physiol , vol.277
    • Kono, H.1    Bradford, B.U.2    Yin, M.3
  • 40
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000; 105: 1067-1075.
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 41
    • 0026005872 scopus 로고
    • Identification and induction of cytochrome P450 2E1 in rat Kupffer cells
    • Koop DR, Chernosky A, Brass EP. Identification and induction of cytochrome P450 2E1 in rat Kupffer cells. J Pharmacol Exp Ther 1991; 258: 1072-1076.
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 1072-1076
    • Koop, D.R.1    Chernosky, A.2    Brass, E.P.3
  • 43
    • 0034070414 scopus 로고    scopus 로고
    • Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4
    • Su GL, Klein RD, Aminlari A etal. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 2000; 31: 932-936.
    • (2000) Hepatology , vol.31 , pp. 932-936
    • Su, G.L.1    Klein, R.D.2    Aminlari, A.3
  • 44
    • 0036074141 scopus 로고    scopus 로고
    • Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation
    • Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G256-265.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Su, G.L.1
  • 45
    • 0033163393 scopus 로고    scopus 로고
    • Is NF-kappaB the sensor of oxidative stress?
    • Li N, Karin M. Is NF-kappaB the sensor of oxidative stress? FASEB J 1999; 13: 1137-1143.
    • (1999) FASEB J , vol.13 , pp. 1137-1143
    • Li, N.1    Karin, M.2
  • 46
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: fifteen years later
    • Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006; 72: 1493-1505.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 47
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono H, Rusyn I, Yin M etal. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000; 106: 867-872.
    • (2000) J Clin Invest , vol.106 , pp. 867-872
    • Kono, H.1    Rusyn, I.2    Yin, M.3
  • 48
    • 0035031846 scopus 로고    scopus 로고
    • Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat
    • Kono H, Rusyn I, Uesugi T etal. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1005-1012.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Kono, H.1    Rusyn, I.2    Uesugi, T.3


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