Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/l-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death

Apoptosis

Volumn 18, Issue 9, 2013, Pages 1048-1059

  Leprêtre, Chloé ^a,b,c   Tchakarska, Guergana ^a,b,c   Blibech, Hounayda ^a,b,c   Lebon, Cécile ^a,b,c   Torriglia, Alicia ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

AIF; Apoptosis; Caspase independent; Chromatin condensation; DNA degradation; Endonuclease; l DNase II

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; DEOXYRIBONUCLEASE II; GENOMIC DNA; LEUKOCYTE ELASTASE INHIBITOR; DEOXYRIBONUCLEASE; PROTEIN BINDING; SERINE PROTEINASE INHIBITOR; SERPINB1 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DENSITY; CELL SURVIVAL; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL LINE; DEGENERATIVE DISEASE; ENZYMOLOGY; GENETICS; METABOLISM;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL LINE; ENDODEOXYRIBONUCLEASES; HUMANS; NEURODEGENERATIVE DISEASES; PROTEIN BINDING; SERPINS;

EID: 84881480576     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0862-2     Document Type: Article

References (48)

1. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al (2012) Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012. Cell Death Differ 19:107-120
2. Boujrad H, Gubkina O, Robert N, Krantic S, Susin SA (2007) AIF-mediated programmed necrosis: a highly regulated way to die. Cell Cycle 6:2612-2619
3. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM et al (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446
4. Dawson VL, Dawson TM (2004) Deadly conversations: nuclear-mitochondrial cross-talk. J Bioenerg Biomembr 36:287-294
5. Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J et al (2007) Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27:4844-4862
6. Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA et al (2002) The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol 9:442-446
7. Delavallee L, Cabon L, Galan-Malo P, Lorenzo HK, Susin SA (2011) AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics. IUBMB Life 63:221-232
8. Joza N, Oudit GY, Brown D, Benit P, Kassiri Z, Vahsen N et al (2005) Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol 25:10261-10272
9. Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN et al (2002) The harlequin mouse mutation down regulates apoptosis-inducing factor. Nature 419:367-374
10. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W et al (2004) Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 24:10963-10973
11. Delettre C, Yuste VJ, Moubarak RS, Bras M, Lesbordes-Brion JC, Petres S et al (2006) AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer. J Biol Chem 281:6413-6427
12. Ishitsuka K, Hideshima T, Hamasaki M, Raje N, Kumar S, Podar K et al (2005) Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene 24:5888-5896
13. Cande C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C et al (2004) AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene 23:1514-1521
14. Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N et al (2007) Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med 204:1741-1748
15. Krieser RJ, Eastman A (1998) The cloning and expression of human deoxyribonuclease II. a possible role in apoptosis. J Biol Chem 273:30909-30914
16. Torriglia A, Perani P, Brossas JY, Chaudun E, Treton J, Courtois Y et al (1998) l-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor. Mol Cell Biol 18:3612-3619
17. Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W et al (2006) An overview of the serpin super family. Genome Biol 7:216
18. Silverman GA, Lomas DA (2004) Serpin identification, production, and characterization. Methods 32:71-72
19. Cooley J, Takayama TK, Shapiro SD, Schechter NM, Remold-O'Donnell E (2001) The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry 40:15762-15770
20. Padron-Barthe L, Courta J, Lepretre C, Nagbou A, Torriglia A (2008) Leukocyte elastase Inhibitor, the precursor of l-DNase II, inhibits apoptosis by interfering with caspase-8 activation. Biochim Biophys Acta 1783:1755-1766
21. Padron-Barthe L, Lepretre C, Martin E, Counis MF, Torriglia A (2007) Conformational modification of serpins transforms leukocyte elastase inhibitor into an endonuclease involved in apoptosis. Mol Cell Biol 27:4028-4036
22. Torriglia A, Chaudun E, Chany-Fournier F, Courtois Y, Counis MF (2001) Involvement of l-DNase II in nuclear degeneration during chick retina development. Exp Eye Res 72:443-453
23. Altairac S, Zeggai S, Perani P, Courtois Y, Torriglia A (2003) Apoptosis induced by Na+/H+antiport inhibition activates the LEI/l-DNase II pathway. Cell Death Differ 10:548-557
24. Belmokhtar CA, Torriglia A, Counis MF, Courtois Y, Jacquemin-Sablon A, Segal-Bendirdjian E (2000) Nuclear translocation of a leukocyte elastase inhibitor/elastase complex during staurosporine-induced apoptosis: role in the generation of nuclear l-DNase II activity. Exp Cell Res 254:99-109
25. Fombonne J, Padron L, Enjalbert A, Krantic S, Torriglia A (2006) A novel paraptosis pathway involving LEI/L-DNaseII for EGF-induced cell death in somato-lactotrope pituitary cells. Apoptosis 11:367-375
26. Gorrini C, Donzelli M, Torriglia A, Supino R, Brison O, Bernardi R et al (2003) Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level. Int J Mol Med 11:737-742
27. Huc L, Rissel M, Solhaug A, Tekpli X, Gorria M, Torriglia A et al (2006) Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells. J Cell Physiol 208:527-537
28. Torriglia A, Negri C, Chaudun E, Prosperi E, Courtois Y, Counis MF et al (1999) Differential involvement of DNases in HeLa cell apoptosis induced by etoposide and long term-culture. Cell Death Differ 6:234-244
29. Bourges JL, Torriglia A, Valamanesh F, Benezra D, Renard G, Behar-Cohen FF (2007) Nitrosative stress and corneal transplant endothelial cell death during acute graft rejection. Transplantation 84:415-423
30. Bourges JL, Valamanesh F, Torriglia A, Jeanny JC, Savoldelli M, Renard G et al (2004) Cornea graft endothelial cells undergo apoptosis by way of an alternate (caspase-independent) pathway. Transplantation 78:316-323
31. Chahory S, Keller N, Martin E, Omri B, Crisanti P, Torriglia A (2010) Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D. Neurochem Int 57:278-287
32. Chahory S, Padron L, Courtois Y, Torriglia A (2004) The LEI/l-DNase II pathway is activated in light-induced retinal degeneration in rats. Neurosci Lett 367:205-209
33. Bottone MG, Soldani C, Tognon G, Gorrini C, Lazze MC, Brison O et al (2003) Multiple effects of paclitaxel are modulated by a high c-myc amplification level. Exp Cell Res 290:49-59
34. Altairac S, Wright SC, Courtois Y, Torriglia A (2003) l-DNase II activation by the 24 kDa apoptotic protease (AP24) in TNFalpha-induced apoptosis. Cell Death Differ 10:1109-1111
35. O'Connell AR, Holohan C, Torriglia A, Lee BW, Stenson-Cox C (2006) Characterization of a serine protease-mediated cell death program activated in human leukemia cells. Exp Cell Res 312:27-39
36. Lepretre C, Scovassi AI, Shah GM, Torriglia A (2009) Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis. Int J Biochem Cell Biol 41:1046-1054
37. Lepretre C, Sidoli G, Scovassi AI, Torriglia A (2009) Leukocyte elastase inhibitor: a new regulator of PARP-1. Ann N Y Acad Sci 1171:25-31
38. Wang Y, Dawson VL, Dawson TM (2009) Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 218:193-202
39. Torriglia A, Chaudun E, Chany-Fournier F, Jeanny JC, Courtois Y, Counis MF (1995) Involvement of DNase II in nuclear degeneration during lens cell differentiation. J Biol Chem 270:28579-28585
40. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (1999) Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401:168-173
41. Hangen E, Blomgren K, Benit P, Kroemer G, Modjtahedi N (2010) Life with or without AIF. Trends Biochem Sci 35:278-287
42. Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA (2010) Histone H2AX: the missing link in AIF-mediated caspase-independent programmed necrosis. Cell Cycle 9:3166-3173
43. Liu KC, Huang YT, Wu PP, Ji BC, Yang JS, Yang JL et al (2011) The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway. Int J Oncol 38:787-796
44. Yuste VJ, Sanchez-Lopez I, Sole C, Moubarak RS, Bayascas JR, Dolcet X et al (2005) The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis. J Biol Chem 280:35670-35683
45. Lin CC, Kuo CL, Lee MH, Lai KC, Lin JP, Yang JS et al (2011) Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. Int J Oncol 39:217-224
46. Torriglia A, Lepretre C, Padron-Barthe L, Chahory S, Martin E (2008) Molecular mechanism of l-DNase II activation and function as a molecular switch in apoptosis. Biochem Pharmacol 76:1490-1502
47. Counis MF, Torriglia A (2000) DNases and apoptosis. Biochem Cell Biol 78:405-414
48. Counis MF, Torriglia A (2006) Acid DNases and their interest among apoptotic endonucleases. Biochimie 88:1851-1858