Nuclear translocation of a leukocyte elastase inhibitor/elastase complex during staurosporine-induced apoptosis: Role in the generation of nuclear L- DNase II activity

Experimental Cell Research

Volumn 254, Issue 1, 2000, Pages 99-109

  Belmokhtar, Chafké Ahmed ^a   Torriglia, Alicia ^b   Counis, Marie France ^b   Courtois, Yves ^b   Jacquemin Sablon, Alain ^c   Ségal Bendirdjian, Evelyne ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b INSERM   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Apoptosis; Cisplatin; Elastase; Endonuclease; L DNase II; L1210 leukemia cells; Staurosporine

Indexed keywords

DEOXYRIBONUCLEASE II; DNA FRAGMENT; ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; NUCLEAR PROTEIN; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME PURIFICATION; IMMUNOBLOTTING; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION;

ANIMALIA; MURINAE;

EID: 0034627773     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4737     Document Type: Article

References (53)

1. Wertz I. E., Hanley M. R. Diverse molecular provocation of programmed cell death. Trends Biochem. Sci. 21:1996;359-364.
2. Cohen J. J., Duke R. C., Fadok V. A., Sellins K. S. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:1992;267-293.
3. Duvall E., Wyllie A. H. Death and the cell. Immunol. Today. 7:1986;115-119.
4. Earnshaw W. C. Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7:1995;337-343.
5. Fisher D. E. Apoptosis in cancer therapy: Crossing the threshold. Cell. 78:1994;539-542.
6. Naito M., Nagashima K., Mashima T., Tsuruo T. Phosphatidylserine externalization is a downstream event of interleukin-1β-converting enzyme family protease activation during apoptosis. Blood. 89:1997;2060-2066.
7. Zamzani N., Suzin S. A., Marchetti P., Hirsch T., Gomez-Monterrey I., Castedo M., Kroemer G. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183:1996;1533-1544.
8. Cohen J. J., Duke R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:1984;38-42.
9. Anzai N., Kawabata H., Hirama T., Masutani H., Ueda Y., Yoshida Y., Okuma M. Types of nuclear endonuclease activity capable of inducing internucleosomal DNA fragmentation are completely different between human CD 34+ cells and their granulocytic descendants. Blood. 86:1995;917-923.
10. Caron-Leslie L. M., Schwartzman R. A., Gaido M. L., Compton M. M., Cidlowski J. A. Identification and characterization of glucocorticoid-regulated nuclease(s) in lymphoid cells undergoing apoptosis. J. Steroid Biochem. Mol. Biol. 40:1991;661-671.
11. Fraser M. J. BioEssays. 16:1994;761-766.
12. Fraser M. J., Tynan S. J., Papaioannou A., Ireland C. M., Pittman S. M. Endo-exonuclease of human leukaemic cells: Evidence for a role in apoptosis. J. Cell. Sci. 109:1996;2343-2360.
13. 2B. J. Biol. Chem. 266:1991;18580-18585.
14. Gottlieb R. A., Giesing H. A., Engler R. L., Babior B. M. The acid deoxyribonuclease of neutrophils: A possible participant in apoptosis-associated genome destruction. Blood. 86:1995;2414-2418.
15. 2+-dependent endonuclease activities of human myeloid leukemia cells capable of producing nucleosomal-size DNA fragmentation. Biochem. Biophys. Res. Commun. 233:1997;133-138.
16. Pandey S., Walker P. R., Sikorska M. Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage. Biochemistry. 36:1997;711-720.
17. Peitsch M. C., Polzar B., Stephan H., Crompton T., MacDonald H. R., Mannherz H. G., Tschopp J. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12:1993;371-377.
18. Peitsch M. C., Polzar B., Tschopp J. About the involvement of deoxyribonuclease I in apoptosis. Cell Death Differ. 1:1994;1-6.
19. Shiokawa D., Ohyama H., Yamada T., Takahashi K., Tanuma S. Identification of an endonuclease responsible for apoptosis in rat thymocytes. Eur. J. Biochem. 226:1994;23-30.
20. Takauji R., Yoshida A., Iwasaki H., Toyama K., Ueda T., Nakamura T. Enhancement of Ca(2+)-dependent endonuclease activity in L1210 cells during apoptosis induced by 1-β-D-arabinofuranosylcytosine: Possible involvement of activating factor(s). Jpn. J. Cancer Res. 86:1995;677-684.
21. Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
22. Urbano A., McCaffrey R., Foss F. Isolation and characterization of NUC70, a cytoplasmic, hematopoietic apoptotic endonuclease. J. Biol. Chem. 273:1998;34820-34827.
23. 2+ and pH. Biochem. Biophys. Res. Commun. 186:1992;782-789.
24. Barry M. A., Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys. 300:1993;440-450.
25. Torriglia A., Chaudun E., Chany-Fournier F., Jeanny J-C., Courtois Y., Counis M-F. Involvement of DNAse II in nuclear degeneration during lens cell differentiation. J. Biol. Chem. 270:1995;28579-28585.
26. Torriglia A., Perani P., Brossas J-Y., Chaudun E., Treton J., Courtois Y., Counis M-F. A molecule links proteases and endonucleases in apoptosis: L-DNase II derives from the ubiquitous serpin, leukocyte elastase inhibitor. Mol. Cell. Biol. 18:1998;3612-3619.
27. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50.
28. Sakahira H., Enari M., Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:1998;96-99.
29. Yasuda T., Takeshita H., Iida R., Nakajima T., Hosomi O., Nakashima Y., Kishi K. Molecular cloning of the cDNA encoding deoxyribonuclease II. J. Biol. Chem. 273:1998;2610-2616.
30. Wang C-C., Lu S-C., Chen H-L., Liao T-H. Porcine spleen deoxyribonuclease II. J. Biol. Chem. 273:1998;17191-17198.
31. Baker K. P., Baron W. F., Henzel W. J., Spencer S. A. Molecular cloning and characterization of human and murine DNase II. Gene. 215:1998;281-289.
32. Krieser R. J., Eastman A. The cloning and expression of human deoxyribonuclease II. J. Biol. Chem. 273:1998;30909-30914.
33. Ségal-Bendirdjian E., Jacquemin-Sablon A. Cisplatin resistance in a murine leukemia cell line is associated with a defective apoptotic process. Exp. Cell Res. 218:1995;201-212.
34. Ségal-Bendirdjian E., Mannone L., Jacquemin-Sablon A. Alteration in p53 pathway and defect in apoptosis contribute independently to cisplatin-resistance. Cell Death Diff. 5:1998;390-400.
35. Eastman A., Schulte N. Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II). Biochemistry. 27:1988;4730-4734.
36. Scheibani N., Jennerwein M. M., Eastman A. DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): Host cell reactivation of damaged plasmid DNA. Biochemistry. 28:1989;3120-3124.
37. Richon V. M., Schulte N., Eastman A. Multiple mechanisms of resistance to cis-diamminedichloroplatinum (II) in murine leukemia L1210 cells. Cancer Res. 47:1987;2056-2061.
38. Miller S. A., Dykes D. D., Polesky H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215.
39. Nieto M. A., Lopez-Rivas A. IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J. Immunol. 143:1989;4166-4170.
40. Yasuda T., Takeshita H., Nakazato E., Nakajima T., Hosomi, Nakashima Y., Kishi K. Activity measurement for deoxyribonucleases I and II with picogram sensitivity based on DNA/SYRBR Green I fluorescence. Anal. Biochem. 255:1998;274-276.
41. Rosenthal A. L., Lacks S. A. Nuclease detection in SDS-polyacrylamide gel electrophoresis. Anal. Biochem. 80:1977;76-90.
42. Christensen S., Valnickova Z., Thögersen I. B., Pizzo S. V., Nielsen H. R., Roepstorff P., Enghild J. J. Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain COOH-terminal to the reactive site loop. J. Biol. Chem. 270:1995;14859-14862.
43. Potempa J., Dubin A., Watorek W., Travis J. An elastase inhibitor from equine leukocyte cytosol belongs to the super family of serpin. Further characterization and amino acid sequence of the reactive center. J. Biol. Chem. 263:1988;7364-7369.
44. Remold-O'Donnell E. A fast-acting elastase inhibitor in human monocytes. J. Exp. Med. 162:1985;2142-2155.
45. Remold-O'Donnell E., Nixon J. C., Rose R. M. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophiles. J. Exp. Med. 169:1989;1071-1086.
46. Reynolds J. E., Li J., Graig R. W., Eastman A. Bcl-2 and Mcl-1 expression in chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp. Cell. Res. 225:1996;430-436.
47. Martin S. J., Green D. R. Protease activation during apoptosis: Death by a thousand cut. Cell. 82:1995;349-352.
48. Patel T., Gores G. J., Kaufman S. H. The role of proteases during apoptosis. FASEB J. 10:1996;587-597.
49. Weaver V. M., Lach B., Walker P. R., Sikorska M. Role of proteolysis in apoptosis: Involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochem. Cell Biol. 71:1993;488-500.
50. Yang J. J., Kettritz R., Falk R. J., Jennette J. C., Gaido M. L. Apoptosis of endothelial cells induced by the neutrophile serine proteases proteinase 3 and elastase. Am. J. Pathol. 149:1996;1617-1626.
51. Wright S. C., Wey Q. S., Zhong J., Zheng H., Kinder D. H., Larrick J. W. Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation. J. Exp. Med. 180:1994;2113-2123.
52. Wright S. C., Schellenberger U., Wang H., Wang Y., Kinder D. H. Chemotherapeutic drugs activation of the AP24 protease in apoptosis: Requirement of caspase3-like-proteases. Biochem. Biophys. Res. Commun. 245:1998;797-803.
53. Kayalar C., Ord T., Testa M. P., Zhong L. T., Bredesen D. E. Cleavage of actin by interleukin 1 β-converting enzyme to reverse DNase I inhibition. Proc. Natl. Acad. Sci., USA. 93:1996;2234-2238.