MicroRNA-376a sensitizes cells following DNA damage by downregulating MEPE expression

Cancer Biotherapy and Radiopharmaceuticals

Volumn 28, Issue 7, 2013, Pages 523-529

  Sheng, Jipo ^a   Luo, Wei ^a   Yu, Fang ^a   Gao, Ning ^a   Hu, Baocheng ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

DNA damage; MEPE; microRNA; target

Indexed keywords

DNA; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; MICRORNA; MICRORNA 376A; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HEK293 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; MICRORNAS; PHOSPHOPROTEINS; TRANSFECTION;

EID: 84881447878     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1446     Document Type: Article

References (34)

1. Rowe PS, de Zoysa PA, Dong R, et al. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 2000;67:54
2. Petersen DN, Tkalcevic GT, Mansolf AL, et al. Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. J Biol Chem 2000; 275:36172
3. Argiro L, Desbarats M, Glorieux FH, et al. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics 2001;74:342
4. Liu S, Wang H, Wang X, et al. MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1. Nucleic Acids Res 2009;37:7447
5. Zhang P, Wang H, Rowe PSN, et al. MEPE/OF45 as a new target for sensitizing human tumor cells to DNA damage inducers. Brit J Cancer 2010;102:862
6. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843
7. Ambros V. microRNAs: Tiny regulators with great potential. Cell 2001;107:823
8. Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: The implications for cancer research. Nat Rev Cancer 2010;10:389
9. Zisoulis DG, Kai ZS, Chang RK, et al. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature 2012; 486:541
10. Kong YW, Ferland-McCollough D, Jackson TJ, et al. micro- RNAs in cancer management. Lancet Oncol 2012;13:e249
11. Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes. Cell 2012;149:515
12. Chitwood DH, Timmermans MC. Small RNAs are on the move. Nature 2010;467:415
13. Chen CZ. MicroRNAs as oncogenes and tumor suppressors. N Engl J Med 2005;353:1768
14. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259
15. Kozomara A, Griffiths-Jones S. miRBase: Integrating micro- RNA annotation and deep-sequencing data. Nucleic Acids Res 2011;39:D152
16. Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009;10:1
17. Lin Y, Yu F, Gao N, et al. microRNA-143 protects cells from DNA damage induced killing by downregulating Fhit expression. Cancer Biother Radiopharm 2011;26:365
18. Liu S, Wei W, Gao N et al. Study on the antibody preparation and the localization of MEPE/OF45 protein. J Chin Gereol 2007;27:1017
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Meth 1983;65:55
20. Ulukaya E, Ozdikicioglu F, Oral AY, et al. The MTT assay yields a relatively lower result of growth inhibition than theATP assay depending on the chemotherapeutic drugs tested. Toxicol In Vitro 2008;22:232
21. Hu B, Zhou XY, Wang X, et al. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J Biol Chem 2001;276:17693
22. Wang X, Khadpe J, Hu B, et al. An over-activated ATR/ CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J Biol Chem 2003;278:30869
23. Hu B, Han SY, Wang X, et al. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J Cell Physiol 2005;202:518
24. Hu B, Wang H, Wang X, et al. Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res 2005;65:8613
25. Wang H, Wang X, Iliakis G, et al. Caffeine could not efficiently sensitize homologous recombination repair deficient cells to ionizing radiation-induced killing. Radiat Res 2003;159:420
26. Wang X, Wang H, Iliakis G, et al. Caffeine-induced radiosensitization is independent of non-homologous end joining of DNA double strand breaks. Radiat Res 2003;159:426
27. Seitz H, Royo H, Bortolin ML, et al. A Large Imprinted microRNA Gene Cluster at the Mouse Dlk1-Gtl2 Domain. Genome Res 2004;14:1741
28. Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004;432:226
29. Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 2007; 315:1137
30. Wang F, Yu J, Yang GH, et al. Regulation of erythroid differentiation by miR-376a and its targets. Cell Res 2011; 21:1196
31. Zehavi L, Avraham R, Barzilai A, et al. Silencing of a large micro-RNA cluster on human chromosome 14q32 in melanoma: Biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor. Mol Cancer 2012;11:44
32. Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev 2000;14:1448
33. Lam MH, Liu Q, Elledge SJ, et al. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004;6:45
34. Gowen LC, Petersen DN, Mansolf AL, et al. Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass. J Biol Chem 2003;278:1998.