Fhit and CHK1 have opposing effects on homologous recombination repair

Cancer Research

Volumn 65, Issue 19, 2005, Pages 8613-8616

  Hu, Baocheng ^a,b   Wang, Hongyan ^b   Wang, Xiang ^b   Lu, Hua Rui ^b   Huang, Cuifen ^a   Powell, Simon N ^c   Huebner, Kay ^d   Wang, Ya ^b  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL KILLING; CHK1 GENE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DNA STRAND BREAKAGE; FHIT GENE; GENE; GENE DELETION; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; IONIZING RADIATION; KNOCKOUT GENE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ACID ANHYDRIDE HYDROLASES; ANIMALS; CELL LINE; DNA; DNA DAMAGE; DNA REPAIR; MICE; NEOPLASM PROTEINS; PROTEIN KINASES; RECOMBINATION, GENETIC; RNA, SMALL INTERFERING;

EID: 25444462208     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1966     Document Type: Article

References (27)

1. Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancer. Cell 1996;84:587-97.
2. Croce CM, Sozzi G, Huebner K. Role of FHIT in human cancer. Biol Neoplasia 1999;17:1618-24.
3. Gatalica Z, Lele SM, Rampy BA, Norris BA. The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma. Cancer 2000;88:1378-83.
4. Huebner K, Croce CM. Cancer and the common fragile site, FRA3B/FHIT: it's a HIT. Br J Cancer 2003;88:1501-6.
5. Ottey M, Han S-Y, Druck T. et al. Fhit deficient normal and cancer cells are mitomycin C and UVC resistant. Br J Cancer 2004;91:1669-77.
6. Hu B, Han S-Y. Wang X et al. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J Cell Phys 2005;202:518-23.
7. Paulovich AG, Hartwell LH. A checkpoint regulates the rate of progression through S phase in S. cerivisiae in response to DNA damage. Cell 1995;82:841-7.
8. Paulovich AG, Toczyski DP, Hartwell LH. When checkpoints fail. Cell 1997;88:315-21.
9. Eller MS, Ostrom K, Gilchrest BA. DNA damage enhances melanogenesis. Proc Natl Acad Sci U S A 1996;93:1087-92.
10. Zhou B, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-9.
11. Martinho RG, Lindsay HD, Flaggs G, et al. Analysis of Rad3 and Chk1 protein kinase defines different checkpoint responses. EMBO J 1998;17:7239-49.
12. Guo Z, Kumagai A, Wang SX, Dunphy WG. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000;14:2745-56.
13. 2/M DNA damage checkpoint. Genes Dev 2000;14:1448-59.
14. Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001;21:4129-39.
15. Hu B, Zhou XY. Wang X et al. The radioresistance to killing of Al-5 cells derives from activation of the Chk1 pathway. J Biol Chem 2001;276:17693-8.
16. Zhou XY, Wang X Hu B, et al. An ATM-independent S phase checkpoint response involves CHK1 pathway. Cancer Res 2002;62:1598-603.
17. 2 checkpoints. Proc Natl Acad Sci U S A 2002;99:14795-800.
18. Wang HY, Wang HC, Powell SN, Iliakis G, Wang Y. ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of non-homologous end joining. Cancer Res 2004;64:7139-43.
19. Wang H, Hu B, Liu R, Wang Y. CHK1 affecting cell radiosensitivity is independent of non-homologous end joining. Cell Cycle 2005;4:300-3.
20. Fong LYY, Fidanza V, Zanesi N, et al. Muir-torre-like syndrome in Fhit-deficient mice. Proc Natl Acad Sci U S A 2000;97:4742-7.
21. Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 1999;13:2633-8.
22. Taghian DG, Nickoloff JA. Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells. Mol Cell Biol 1997;17:6386-93.
23. Wang HY, Hu B, Liu RH, Wang Y. CHK1 affecting cell radiosensitivity is independent of non-homologous end joining. Cell Cycle 2005;4:e48-51.
24. Richardson C, Stark JM, Ommundsen M, Jasin M. Rad51 overexpression promotes alternative double-strand break repair pathways and genomic instability. Oncogene 2004;23:546-53.
25. 2 phase DNA double-strand break repair. J Biol Chem 2001;276:44413-8.
26. Pierce AJ, Hu P, Han M, Ellis N, Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 2001;15:3237-42.
27. Li GC, Ouyang H, Li X et al. Ku70: a candidate tumor suppressor gene for murine T cell lymphoma Mol Cell 1998;2:1-8.