메뉴 건너뛰기




Volumn 6, Issue 7, 2011, Pages

Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYCHLOROQUINE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; PROLACTIN; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; BIOLOGICAL MARKER;

EID: 79960657991     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021671     Document Type: Article
Times cited : (41)

References (33)
  • 1
    • 0025990288 scopus 로고
    • Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
    • Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, et al. (1991) Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 147: 117-123.
    • (1991) J Immunol , vol.147 , pp. 117-123
    • Linker-Israeli, M.1    Deans, R.J.2    Wallace, D.J.3    Prehn, J.4    Ozeri-Chen, T.5
  • 2
    • 8144224559 scopus 로고    scopus 로고
    • Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescentsystemic lupus erythematosus: Could longitudinal studies reveal patient subgroups of differing pathology?
    • Capper ER, Maskill JK, Gordon C, Blakemore AI, (2004) Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescentsystemic lupus erythematosus: Could longitudinal studies reveal patient subgroups of differing pathology? Clin Exp Immunol 138: 348-356.
    • (2004) Clin Exp Immunol , vol.138 , pp. 348-356
    • Capper, E.R.1    Maskill, J.K.2    Gordon, C.3    Blakemore, A.I.4
  • 3
    • 33645858280 scopus 로고    scopus 로고
    • Interferon pathway activation in systemic lupus erythematosus
    • Crow MK, (2005) Interferon pathway activation in systemic lupus erythematosus. Curr Rheumatol Rep 7: 463-468.
    • (2005) Curr Rheumatol Rep , vol.7 , pp. 463-468
    • Crow, M.K.1
  • 4
    • 0033548048 scopus 로고    scopus 로고
    • Erythropoietin receptor activation by a ligand-induced conformation change
    • Remy I, Wilson IA, Michnick SW, (1999) Erythropoietin receptor activation by a ligand-induced conformation change. Science 283: 990-993.
    • (1999) Science , vol.283 , pp. 990-993
    • Remy, I.1    Wilson, I.A.2    Michnick, S.W.3
  • 5
    • 0036256836 scopus 로고    scopus 로고
    • JAK-STAT signaling in human disease Clin
    • Christian W, Schindler J, (2002) JAK-STAT signaling in human disease Clin. Invest 109: 1133-1137.
    • (2002) Invest , vol.109 , pp. 1133-1137
    • Christian, W.1    Schindler, J.2
  • 6
    • 33847375175 scopus 로고    scopus 로고
    • Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
    • Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, et al. (2007) Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity 40: 1-8.
    • (2007) Autoimmunity , vol.40 , pp. 1-8
    • Harada, T.1    Kyttaris, V.2    Li, Y.3    Juang, Y.T.4    Wang, Y.5
  • 7
    • 33847419628 scopus 로고    scopus 로고
    • Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice
    • Dong J, Wang QX, Zhou CY, Ma XF, Zhang YC, (2007) Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice. Lupus 16: 101-109.
    • (2007) Lupus , vol.16 , pp. 101-109
    • Dong, J.1    Wang, Q.X.2    Zhou, C.Y.3    Ma, X.F.4    Zhang, Y.C.5
  • 8
    • 34547760841 scopus 로고    scopus 로고
    • Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis
    • Martinez-Lostao L, Ordi-Ros J, Balada E, Segarra-Medrano A, Majó-Masferrer J, et al. (2007) Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis. Lupus 16: 483-488.
    • (2007) Lupus , vol.16 , pp. 483-488
    • Martinez-Lostao, L.1    Ordi-Ros, J.2    Balada, E.3    Segarra-Medrano, A.4    Majó-Masferrer, J.5
  • 9
    • 66049126061 scopus 로고    scopus 로고
    • Activation of the Interferon- Signaling Pathway in Systemic Lupus Erythematosus Peripheral Blood Mononuclear Cells
    • Karonitsch T, Feierl E, Steiner CW, Dalwigk K, Korb A, et al. (2009) Activation of the Interferon- Signaling Pathway in Systemic Lupus Erythematosus Peripheral Blood Mononuclear Cells. Arthritis Rheum 60: 1463-1471.
    • (2009) Arthritis Rheum , vol.60 , pp. 1463-1471
    • Karonitsch, T.1    Feierl, E.2    Steiner, C.W.3    Dalwigk, K.4    Korb, A.5
  • 10
    • 3242683662 scopus 로고    scopus 로고
    • Single cell profiling of potentiated phospho-protein networks in cancer cells
    • Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud O, et al. (2004) Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell 118: 217-228.
    • (2004) Cell , vol.118 , pp. 217-228
    • Irish, J.M.1    Hovland, R.2    Krutzik, P.O.3    Perez, O.D.4    Bruserud, O.5
  • 11
    • 33645318725 scopus 로고    scopus 로고
    • Phospho-proteomic immune analysis by flow cytometry: From mechanism to translational medicine at the single-cell level
    • Perez OD, Nolan GP, (2006) Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level. Immunological Reviews 210: 208-228.
    • (2006) Immunological Reviews , vol.210 , pp. 208-228
    • Perez, O.D.1    Nolan, G.P.2
  • 12
    • 41149124865 scopus 로고    scopus 로고
    • Phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection
    • Lee AW, Sharp ER, O'Mahony A, Rosenberg MG, Israelski DM, et al. (2008) phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection. J Virol 82: 3702-3712.
    • (2008) J Virol , vol.82 , pp. 3702-3712
    • Lee, A.W.1    Sharp, E.R.2    O'Mahony, A.3    Rosenberg, M.G.4    Israelski, D.M.5
  • 13
    • 79956275308 scopus 로고    scopus 로고
    • Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples
    • Krutzik PO, Trejo A, Schulz KR, Nolan GP, (2011) Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples. Methods Mol Biol 699: 179-202.
    • (2011) Methods Mol Biol , vol.699 , pp. 179-202
    • Krutzik, P.O.1    Trejo, A.2    Schulz, K.R.3    Nolan, G.P.4
  • 14
    • 77958548694 scopus 로고    scopus 로고
    • Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells
    • Lin CC, Huang WL, Su WP, Chen HH, et al. (2010) Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells. Cytometry A 77: 1008-1019.
    • (2010) Cytometry A , vol.77 , pp. 1008-1019
    • Lin, C.C.1    Huang, W.L.2    Su, W.P.3    Chen, H.H.4
  • 15
    • 77956892628 scopus 로고    scopus 로고
    • Quantification of intracellular proteins and monitoring therapy using flow cytometry
    • Chang RL, Yeh CH, Albitar M, (2010) Quantification of intracellular proteins and monitoring therapy using flow cytometry. Curr Drug Targets 11: 994-999.
    • (2010) Curr Drug Targets , vol.11 , pp. 994-999
    • Chang, R.L.1    Yeh, C.H.2    Albitar, M.3
  • 16
    • 69449090795 scopus 로고    scopus 로고
    • Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus
    • Hale MB, Krutzik PO, Samra SS, Crane JM, Nolan GP, (2009) Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus. PLoS One 2009 4: e6756.
    • (2009) PLoS One 2009 , vol.4
    • Hale, M.B.1    Krutzik, P.O.2    Samra, S.S.3    Crane, J.M.4    Nolan, G.P.5
  • 17
    • 69049104337 scopus 로고    scopus 로고
    • Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: Implications for diagnosis and monitoring drug therapy
    • Galligan CL, Siebert JC, Siminovitch KA, Keystone EC, Bykerk V, et al. (2009) Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy. PLoS One 4: e6703.
    • (2009) PLoS One , vol.4
    • Galligan, C.L.1    Siebert, J.C.2    Siminovitch, K.A.3    Keystone, E.C.4    Bykerk, V.5
  • 18
    • 0020436689 scopus 로고
    • The 1982 revised criteria for the classification of systemic lupus erythematosus
    • Tan EM, Cohen AS, Fries JF, Masi AT, Mcshane DJ, et al. (1982): The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25: 1271-1277.
    • (1982) Arthritis Rheum , vol.25 , pp. 1271-1277
    • Tan, E.M.1    Cohen, A.S.2    Fries, J.F.3    Masi, A.T.4    McShane, D.J.5
  • 19
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5
  • 20
    • 0036158415 scopus 로고    scopus 로고
    • Systemic Lupus Erythematosus Disease Activity Index 2000
    • Gladman DD, Ibanez D, Urowitz MB, (2002) Systemic Lupus Erythematosus Disease Activity Index 2000. J Rheumatol 29: 288-291.
    • (2002) J Rheumatol , vol.29 , pp. 288-291
    • Gladman, D.D.1    Ibanez, D.2    Urowitz, M.B.3
  • 21
    • 0036645183 scopus 로고    scopus 로고
    • Interactively exploring hierarchical clustering results
    • Seo J, Shneiderman B, (2002) Interactively exploring hierarchical clustering results. Computer 35: 80-88.
    • (2002) Computer , vol.35 , pp. 80-88
    • Seo, J.1    Shneiderman, B.2
  • 22
    • 2942672845 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-5 activation and breast cancer prognosis
    • Nevalainen MT, Xie J, Torhorst J, Bubendorf L, Haas P, et al. (2004) Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol 22: 2053-2060.
    • (2004) J Clin Oncol , vol.22 , pp. 2053-2060
    • Nevalainen, M.T.1    Xie, J.2    Torhorst, J.3    Bubendorf, L.4    Haas, P.5
  • 23
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, et al. (2008) Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell 14: 335-343.
    • (2008) Cancer Cell , vol.14 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3    Simonds, E.F.4    Sakai, D.S.5
  • 24
    • 0036214521 scopus 로고    scopus 로고
    • Prolactin activates the cyclin D1 promoter via the JAK2-STAT pathway
    • Brockman JL, Schroeder MD, Schuler LA, (2002) Prolactin activates the cyclin D1 promoter via the JAK2-STAT pathway. Mol Endocrinol 16: 774-784.
    • (2002) Mol Endocrinol , vol.16 , pp. 774-784
    • Brockman, J.L.1    Schroeder, M.D.2    Schuler, L.A.3
  • 25
    • 20544444128 scopus 로고    scopus 로고
    • Prolactin signals via STAT5 and Oct-1 to the proximal cyclin D1 promoter
    • Brockman JL, Schuler LA, (2005) Prolactin signals via STAT5 and Oct-1 to the proximal cyclin D1 promoter. Mol Cell Endocrinol 239: 45-53.
    • (2005) Mol Cell Endocrinol , vol.239 , pp. 45-53
    • Brockman, J.L.1    Schuler, L.A.2
  • 26
    • 33847375175 scopus 로고    scopus 로고
    • Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
    • Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, et al. (2007) Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity 40: 1-8.
    • (2007) Autoimmunity , vol.40 , pp. 1-8
    • Harada, T.1    Kyttaris, V.2    Li, Y.3    Juang, Y.T.4    Wang, Y.5
  • 27
    • 38149109907 scopus 로고    scopus 로고
    • STAT5 as a diagnostic marker for leukemia
    • Lewis RS, Ward AC, (2008) STAT5 as a diagnostic marker for leukemia. Expert Rev Mol Diagn 8: 73-82.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 73-82
    • Lewis, R.S.1    Ward, A.C.2
  • 28
    • 33747079946 scopus 로고    scopus 로고
    • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
    • Fleenor D, Arumugam R, Freemark M, (2006) Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. Horm Res 66: 101-110.
    • (2006) Horm Res , vol.66 , pp. 101-110
    • Fleenor, D.1    Arumugam, R.2    Freemark, M.3
  • 29
    • 0030047671 scopus 로고    scopus 로고
    • Prolactin induced immunoglobulin and autoantibody production by peripheral blood mononuclear cells from systemic lupus erythematosus and normal individuals
    • Gutiérrez MA, Molina JF, Jara LJ, Garcia C, Gutiérrez-Ureña S, et al. (1996) Prolactin induced immunoglobulin and autoantibody production by peripheral blood mononuclear cells from systemic lupus erythematosus and normal individuals. Int Arch Allergy Immunol 109: 229-235.
    • (1996) Int Arch Allergy Immunol , vol.109 , pp. 229-235
    • Gutiérrez, M.A.1    Molina, J.F.2    Jara, L.J.3    Garcia, C.4    Gutiérrez-Ureña, S.5
  • 30
    • 0034882859 scopus 로고    scopus 로고
    • Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity
    • Jacobi AM, Rohde W, Ventz M, Burmester GR, Hiepe F, (2001) Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity. Lupus 10: 554-561.
    • (2001) Lupus , vol.10 , pp. 554-561
    • Jacobi, A.M.1    Rohde, W.2    Ventz, M.3    Burmester, G.R.4    Hiepe, F.5
  • 31
    • 0035154194 scopus 로고    scopus 로고
    • Bromocriptine treatment of systemic lupus erythematosus
    • Walker SE, (2001) Bromocriptine treatment of systemic lupus erythematosus. Lupus 10: 762-768.
    • (2001) Lupus , vol.10 , pp. 762-768
    • Walker, S.E.1
  • 32
    • 0033818960 scopus 로고    scopus 로고
    • Mood states and disease activity in patients with systemic lupus erythematosus treated with bromocriptine
    • Walker SE, Smarr KL, Parker JC, Weidensaul DN, Nelson W, et al. (2000) Mood states and disease activity in patients with systemic lupus erythematosus treated with bromocriptine. Lupus 9: 527-33.
    • (2000) Lupus , vol.9 , pp. 527-533
    • Walker, S.E.1    Smarr, K.L.2    Parker, J.C.3    Weidensaul, D.N.4    Nelson, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.