The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cells

Experimental Neurology

Volumn 247, Issue , 2013, Pages 438-446

  Kanazawa, Yasushi ^a,b   Takahashi Fujigasaki, Junko ^b   Ishizawa, Sho ^a   Takabayashi, Naoko ^b   Ishibashi, Kumiko ^b   Matoba, Keiichiro ^a   Kawanami, Daiji ^a   Yokota, Tamotsu ^a   Tajima, Naoko ^a   Utsunomiya, Kazunori ^a  

^a Department of Internal Medicine   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetic neuropathy; E cadherin; Fasudil; Motor nerve conduction velocity; P120 catenin; Rho kinase; Schmidt Lanterman incisures

Indexed keywords

BETA CATENIN; CATENIN; FASUDIL; P120 CATENIN; RHO FACTOR; RHO KINASE; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL JUNCTION; CONTROLLED STUDY; DIABETIC NEUROPATHY; DRUG MECHANISM; ENZYME ACTIVITY; MALE; MOTOR NERVE CONDUCTION; MYELIN SHEATH; MYELINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SCHWANN CELL;

ADHERENS JUNCTION; AJ; DIABETIC NEUROPATHY; E-CADHERIN; FASUDIL; MNCV; MOTOR NERVE CONDUCTION VELOCITY; P120 CATENIN; P120 CTN; RHO-KINASE; SCHMIDT-LANTERMAN INCISURES; STREPTOZOTOCIN; STZ;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BETA CATENIN; BODY WEIGHT; CADHERINS; CATENINS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION; MALE; NERVE TISSUE PROTEINS; NEURAL CONDUCTION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RHO FACTOR; RHO-ASSOCIATED KINASES; SCHWANN CELLS; SCIATIC NERVE;

EID: 84881370423     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.01.012     Document Type: Article

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