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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4857-4861

Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain

(16) Beebe, Xenia a Yeung, Clinton M a Darczak, Daria a Shekhar, Shashank a Vortherms, Timothy A a Miller, Loan a Milicic, Ivan a Swensen, Andrew M a Zhu, Chang Z a Banfor, Patricia a Wetter, Jill M a Marsh, Kennan C a Jarvis, Michael F a Scott, Victoria E a Schrimpf, Michael R a Lee, Chih Hung a

a ABBVIE INC (United States)

Author keywords

Analgesia; Enantiomeric synthesis; Microsomal stability; N type calcium channels; SAR

Indexed keywords

4 AMINOCYCLOPENTAPYRROLIDINE DERIVATIVE; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATORY PAIN; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESIA; ENANTIOMERIC SYNTHESIS; MICROSOMAL STABILITY; N-TYPE CALCIUM CHANNELS; SAR;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; HUMANS; MICROSOMES; NEURALGIA; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881369115 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.074 Document Type: Article

Times cited : (8)

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