A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 869-873

  Tyagarajan, Sriram ^a   Chakravarty, Prasun K ^a   Park, Min ^a   Zhou, Bishan ^a   Herrington, James B ^a   Ratliff, Kevin ^a   Bugianesi, Randall M ^a   Williams, Brande ^a   Haedo, Rodolfo J ^a   Swensen, Andrew M ^a   Warren, Vivien A ^a   Smith, McHardy ^a   Garcia, Maria ^a   Kaczorowski, Gregory J ^a   McManus, Owen B ^a   Lyons, Kathryn A ^a   Li, Xiaohua ^a   Madeira, Maria ^a   Karanam, Bindhu ^a   Green, Mitchell ^a   Forrest, Michael J ^a   Abbadie, Catherine ^a   McGowan, Erin ^a   Mistry, Shruti ^a   Jochnowitz, Nina ^a   Duffy, Joseph L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ca v2.2 blockers; Chung model; Indoles; N type calcium channel; Pain

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; EXPERIMENTAL DOG; HAPLORHINI; HUMAN; IC 50; LIVER MICROSOME METABOLISM; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; DOGS; HAPLORHINI; HUMANS; INDOLES; PAIN; RATS;

EID: 78651255984     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.067     Document Type: Article

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