A novel series of pyrazolylpiperidine N-type calcium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4080-4083

  Subasinghe, Nalin L ^a   Wall, Mark J ^a   Winters, Michael P ^a   Qin, Ning ^a   Lubin, Mary Lou ^a   Finley, Michael F A ^a   Brandt, Michael R ^a   Neeper, Michael P ^a   Schneider, Craig R ^a   Colburn, Raymond W ^a   Flores, Christopher M ^a   Sui, Zhihua ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Chronic pain; N Type calcium channel blockers; Neuropathic pain; Piperidine; Pyrazole; Small molecule

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; PIPERIDINE DERIVATIVE; PYRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STABILITY; ELECTROPHYSIOLOGY; HIGH THROUGHPUT SCREENING; IN VIVO STUDY; INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PATCH CLAMP; RAT;

ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELL LINE; CHRONIC PAIN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NEURALGIA; OMEGA-CONOTOXINS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 84861574787     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.075     Document Type: Article

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