Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1121-1126

  Hu, Lain Yen ^a   Ryder, Todd R ^a   Nikam, Sham S ^a   Millerman, Elizabeth ^b   Szoke, Balazs G ^b   Rafferty, Michael F ^a  

^a PFIZER INC   (United States)

^b ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; LEUCINE; OMEGA CONOTOXIN MVIIA; PD 175069; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS;

CALCIUM CHANNEL BLOCKERS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PHENYLALANINE; TUMOR CELLS, CULTURED;

EID: 0033583556     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00160-2     Document Type: Article

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13. 4
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17. 4) Calcd: C 71.09, H 8.66, N 8.03; Found: C 71.25, H 8.40, N 7.72.