Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3317-3319

  Yamamoto, Takashi ^a   Ohno, Seiji ^a   Niwa, Seiji ^a   Tokumasu, Munetaka ^a   Hagihara, Masako ^a   Koganei, Hajime ^a   Fujita, Shin Ichi ^a   Takeda, Tomoko ^a   Saitou, Yuki ^a   Iwayama, Satoshi ^a   Takahara, Akira ^a   Iwata, Seinosuke ^a   Shoji, Masataka ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

1,4 Dihydropyridine derivative; Asymmetric synthesis; N type calcium channel blocker; Structure activity relationships

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 6 DIMETHOXYMETHYL 1,4 DIHYDROPYRIDINE 3 CARBOXYLIC ACID DERIVATIVE; APJ 2708; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CILNIDIPINE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CONTROLLED STUDY; DRUG SCREENING; HUMAN; HUMAN CELL; ISOMER; MICHAEL ADDITION;

ANIMALS; CALCIUM CHANNELS, N-TYPE; CARBOXYLIC ACIDS; CELL LINE, TUMOR; DIHYDROPYRIDINES; HUMANS; METHYL ETHERS; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79956126300     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.007     Document Type: Article

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