The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity

Obesity

Volumn 21, Issue 6, 2013, Pages 1165-1173

  Bravard, Amélie ^a   Veilleux, Alain ^b   Disse, Emmanuel ^a,c,d   Laville, Martine ^a,c,d   Vidal, Hubert ^a,c   Tchernof, André ^b   Rieusset, Jennifer ^a,c  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ LAVAL   (Canada)

^c Centre de Recherche en Nutrition Humaine   (France)

^d HOSPICES CIVILS DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FAT MASS AND OBESITY ASSOCIATED PROTEIN; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; ROSIGLITAZONE; UNCLASSIFIED DRUG; UNCLASSIFIED ENZYME;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; FAT MASS; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE LOCATION; GENETIC CORRELATION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; MALE; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OMENTUM; SUBCUTANEOUS FAT; TISSUE DISTRIBUTION;

EID: 84881330402     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20110     Document Type: Article

References (36)

1. Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726.
2. Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2007; 2: e1361.
3. Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
4. Hunt SC, Stone S, Xin Y, et al. Association of the FTO gene with BMI. Obesity (Silver Spring) 2008; 16: 902-904.
5. Sun Y, Sun J, Wang X, et al. Variants in the fat mass and obesity associated (FTO) gene are associated with obesity and C-reactive protein levels in Chinese Han populations. Clin Invest Med 2011; 33: E405-E412.
6. Wing MR, Ziegler JM, Langefeld CD, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes 2011;35:1173-1182.
7. Sanghera DK, Ortega L, Han S, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008; 9: 59.
8. Legry V, Cottel D, Ferrieres J, et al. Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study. Metabolism 2009; 58: 971-975.
9. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18-24.
10. Yajnik CS, Janipalli CS, Bhaskar S, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 2009; 52: 247-252.
11. Tews D, Fischer-Posovszky P, Wabitsch M,. FTO-friend or foe? Horm Metab Res 2009;42:75-80.
12. Fischer J, Koch L, Emmerling C, et al. Inactivation of the Fto gene protects from obesity. Nature 2009; 458: 894-898.
13. Church C, Lee S, Bagg EA, et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009; 5: e1000599.
14. Church C, Moir L, McMurray F, et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2011; 42: 1086-1092.
15. Fredriksson R, Hagglund M, Olszewski PK, et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008; 149: 2062-2071.
16. Kloting N, Schleinitz D, Ruschke K, et al. Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia 2008; 51: 641-647.
17. Terra X, Auguet T, Porras JA, et al. Anti-inflammatory profile of FTO gene expression in adipose tissues from morbidly obese women. Cell Physiol Biochem 2011; 26: 1041-1050.
18. Grunnet LG, Nilsson E, Ling C, et al. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 2009; 58: 2402-2408.
19. Lappalainen T, Kolehmainen M, Schwab U, et al. Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line. J Nutrigenet Nutrigenomics 2011; 3: 37-45.
20. Zabena C, Gonzalez-Sanchez JL, Martinez-Larrad MT, et al. The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 2009; 19: 87-95.
21. Samaras K, Botelho NK, Chisholm DJ, et al. Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health. Obes Surg 2010; 20: 108-113.
22. Wahlen K, Sjolin E, Hoffstedt J,. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 2008; 49: 607-611.
23. Bravard A, Lefai E, Meugnier E, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011; 60: 258-268.
24. Tews D, Fischer-Posovszky P, Wabitsch M,. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm Metab Res 2011; 43: 17-21.
25. Friebe D, Loffler D, Schonberg M, et al. Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes. PLoS One 2011; 6: e19526.
26. Wu Q, Saunders RA, Szkudlarek-Mikho M, et al. The obesity-associated Fto gene is a transcriptional coactivator. Biochem Biophys Res Commun 2010; 401: 390-395.
27. Tchernof A, Belanger C, Morisset AS, et al. Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution. Diabetes 2006; 55: 1353-1360.
28. Deschenes D, Couture P, Dupont P, et al. Subdivision of the subcutaneous adipose tissue compartment and lipid-lipoprotein levels in women. Obes Res 2003; 11: 469-476.
29. Ducluzeau PH, Perretti N, Laville M, et al. Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 2001; 50: 1134-1142.
30. Meugnier E, Rome S, Vidal H,. Regulation of gene expression by glucose. Curr Opin Clin Nutr Metab Care 2007; 10: 518-522.
31. Erman A, Veilleux A, Tchernof A, et al. Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women. Int J Obes 2011; 35: 1511-1519.
32. Fujiki K, Kano F, Shiota K, et al. Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes. BMC Biol 2009; 7: 38.
33. Susleyici-Duman B, Zengin K, Kayhan FE, et al. FTO mRNA expression in extremely obese and type 2 diabetic human omental and subcutaneous adipose tissues. Obes Surg 2011;21:1766-1773.
34. Gastaldelli A, Miyazaki Y, Pettiti M, et al. Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 2002; 87: 5098-5103.
35. Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472.
36. Jia G, Yang CG, Yang S, et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 2008; 582: 3313-3319.