FTO mRNA expression in extremely obese and type 2 diabetic human omental and subcutaneous adipose tissues

Obesity Surgery

Volumn 21, Issue 11, 2011, Pages 1766-1773

  Süsleyici Duman, Belgin ^a   Zengin, Kaǧan ^b   Kayhan, Figen Esin ^a   Koldemir, Meliha ^a   DaǧIstanlI, Fatma Kaya ^b   Çaǧatay, Penbe ^c   Öztürk, Melek ^b   TaşkIn, Mustafa ^b  

^a MARMARA UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Adiposity; CD68; Drug; FTO expression; Morbid obesity; Omental fat; Subcutaneous fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CD68 ANTIGEN; MESSENGER RNA;

ADIPOCYTE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL COUNT; CELL FUNCTION; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ELECTIVE SURGERY; EXCISION; FAT MASS AND OBESITY ASSOCIATED PROTEIN GENE; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; MACROPHAGE; MALE; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OMENTUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; TISSUE SECTION;

ADULT; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; OBESITY, MORBID; OMENTUM; PROTEINS; RNA, MESSENGER; SUBCUTANEOUS FAT;

EID: 84155169080     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-011-0446-6     Document Type: Article

References (40)

1. DE Moller KD Kaufman 2005 Metabolic syndrome: a clinical and molecular perspective Annu Rev Med 56 45 62 15660501 10.1146/annurev.med.56.082103.104751 1:CAS:528:DC%2BD2MXisVSrsLg%3D
2. EE Kershaw JS Flier 2004 Adipose tissue as an endocrine organ J Clin Endocrinol Metab 89 2548 56 15181022 10.1210/jc.2004-0395 1:CAS:528: DC%2BD2cXmtlGqt7s%3D
3. G Fantuzzi 2005 Adipose tissue, adipokines, and inflammation J Allergy Clin Immunol 115 911 9 15867843 10.1016/j.jaci.2005.02.023 1:CAS:528: DC%2BD2MXjslKju7o%3D
4. P Kopelman 2007 Health risks associated with overweight and obesity Obes Rev 8 13 7 17316295 10.1111/j.1467-789X.2007.00311.x
5. MM Ibrahim 2010 Subcutaneous and visceral adipose tissue: structural and functional differences Obes Rev 11 11 8 19656312 10.1111/j.1467-789X.2009.00623. x
6. JM Bruun AS Lihn SB Pedersen, et al. 2005 Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT J Clin Endocrinol Metab 90 2282 9 15671098 10.1210/jc.2004-1696 1:CAS:528:DC%2BD2MXjsFWju7s%3D
7. CA Curat V Wegner C Sengenès, et al. 2006 Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin Diabetologia 49 744 7 16496121 10.1007/s00125-006-0173-z 1:CAS:528:DC%2BD28XitF2jtrc%3D
8. SP Weisberg D McCann M Desai, et al. 2003 Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 1796 808 14679176 1:CAS:528:DC%2BD3sXhtVSmtLvO
9. P Bjorntrop 2001 Do stress reactions cause abdominal obesity and comorbidities Obes Rev 2 73 86 10.1046/j.1467-789x.2001.00027.x
10. P Mårin B Andersson M Ottosson, et al. 1992 The morphology and metabolism of intra-abdominal adipose tissue in men Metabolism 41 1241 8
11. A Hisra NK Vikram 2003 Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots Nutrition 19 457 66 10.1016/S0899-9007(02)01003-1
12. K Samaras NK Botelho DJ Chisholm, et al. 2010 Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health Obes Surg 20 108 13 19763711 10.1007/s11695-009-9952-1
13. D Stejskal M Karpisek 2006 Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome? Eur J Clin Investig 36 621 5 10.1111/j.1365-2362.2006.01696.x 1:CAS:528:DC%2BD28XhtVeqtLzI
14. JM Marchington CM Pond 1990 Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro Int J Obes 14 1013 22 2086494 1:STN:280:DyaK3M3gtV2lsg%3D%3D
15. D Corradi R Maestri S Callegari, et al. 2004 The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts Cardiovasc Pathol 13 313 6 15556777 10.1016/j.carpath.2004.08.005
16. AJ Stunkard 1991 Genetic contributions to human obesity Res Publ Assoc Res Nerv Ment Dis 69 205 18 2003161 1:STN:280:DyaK3M7msVGlug%3D%3D
17. S Kim N Moustaid-Moussa 2000 Secretory, endocrine and autocrine/paracrine function of the adipocyte J Nutr 130 3110 5
18. BL Gabrielsson B Carlsson LM Carlsson 2000 Partial genome scale analysis of gene expression in human adipose tissue using DNA array Obes Res 8 374 84 10968729 10.1038/oby.2000.45 1:CAS:528:DC%2BD3cXmsVGhu78%3D
19. CT Montague O Rahilly 2000 The perils of portliness: causes and consequences of visceral adiposity Diabetes 49 883 8 10866038 10.2337/diabetes.49.6.883 1:CAS:528:DC%2BD3cXjvFyltbk%3D
20. N Abate A Garg RM Peshock, et al. 1995 Relationships of generalized and regional adiposity to insulin sensitivity in men J Clin Invest 96 88 98 7615840 10.1172/JCI118083 1:CAS:528:DyaK2MXmslyrurY%3D
21. BL Wajchenberg 2000 Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome Endocr Rev 21 697 738 11133069 10.1210/er.21.6.697 1:STN:280:DC%2BD3M7jslKntQ%3D%3D
22. LE Wagenknecht CD Langefeld AL Scherzinger, et al. 2003 Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study Diabetes 52 2490 6 14514631 10.2337/diabetes.52.10.2490 1:CAS:528:DC%2BD3sXotVWhsL4%3D
23. J Kremen M Dolinkova J Krajickova, et al. 2006 Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance J Clin Endocrinol Metab 91 4620 7 16895955 10.1210/jc.2006-1044 1:CAS:528: DC%2BD28Xht1WhurnL
24. GD Tan C Debard T Funahashi, et al. 2005 Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy Diabetologia 48 1585 9 15991021 10.1007/s00125-005-1835-y 1:CAS:528:DC%2BD2MXnslyrtLw%3D
25. M Kolak H Yki-Järvinen K Kannisto, et al. 2007 Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes J Clin Endocrinol Metab 92 720 4 17148569 10.1210/jc.2006-1465 1:CAS:528:DC%2BD2sXitVaktL8%3D
26. T Peters 1999 Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation Mamm Genome 10 983 6 10501967 10.1007/s003359901121 1:CAS:528:DyaK1MXmtlCru7k%3D
27. F van der Hoeven 1994 Programmed cell death is affected in the novel mouse mutant Fused toes (Ft) Development 120 2601 7 7956835
28. T Gerken 2007 The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science 318 1469 72 17991826 10.1126/science.1151710 1:CAS:528:DC%2BD2sXhtlGmtLbI
29. S Robbens 2008 The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae J Mol Evol 66 80 4 18058156 10.1007/s00239-007- 9059-z 1:CAS:528:DC%2BD1cXhtFers7o%3D
30. L Sanchez-Pulido MA Andrade-Navarro 2007 The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily BMC Biochem 8 23 17996046 10.1186/1471-2091-8-23
31. CL Holness RP Da Silva J Fawcett, et al. 1993 Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family J Biol Chem 268 9661 6 8486654 1:CAS:528:DyaK3sXltFGjsr0%3D
32. KG Alberti P Zimmet J Shaw, et al. 2005 The metabolic syndrome: a new worldwide definition Lancet 366 1059 62 16182882 10.1016/S0140-6736(05)67402-8
33. B Vural F Atalar C Ciftci, et al. 2008 Presence of fatty acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome Cardiovasc Pathol 17 392 8 18417367 10.1016/j.carpath.2008.02.006 1:CAS:528:DC%2BD1cXhtlCqsrbN
34. UN Das AA Rao 2007 Gene expression profile in obesity and type 2 diabetes mellitus Lipids Health Dis 6 35 18078524 10.1186/1476-511X-6-35
35. X Terra T Auguet JA Porras, et al. 2010 Anti-inflammatory profile of FTO gene expression in adipose tissues from morbidly obese women Cell Physiol Biochem 26 1041 50 21220935 10.1159/000323979 1:CAS:528:DC%2BC3MXjtFajug%3D%3D
36. T Lappalainen M Kolehmainen U Schwab, et al. 2010 Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line J Nutrigenet Nutrigenomics 3 37 45 20948226 10.1159/000320732 1:CAS:528:DC%2BC3cXht12ks7bN
37. C Zabena JL González-Sánchez MT Martínez-Larrad, et al. 2009 The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients Obes Surg 19 87 95 18855084 10.1007/s11695-008-9727-0
38. M Villalobos-Comparán MT Flores-Dorantes MT Villarreal-Molina, et al. 2008 The FTO gene is associated with adulthood obesity in the Mexican population Obesity 16 2296 301 18719664 10.1038/oby.2008.367
39. N Klöting D Schleinitz K Ruschke, et al. 2008 Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans Diabetologia 51 641 7 18251005 10.1007/s00125-008-0928-9
40. GB Di Gregorio A Yao-Borengasser N Rasouli, et al. 2005 Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues. Association with cytokine expression, Insulin resistance, and reduction by pioglitazone Diabetes 54 2305 13 16046295 10.2337/diabetes.54.8.2305