Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children

BMC Medical Genetics

Volumn 14, Issue 1, 2013, Pages

  Mejía Benítez, Aurora ^a   Klünder Klünder, Miguel ^b   Yengo, Loic ^c,d   Meyre, David ^e   Aradillas, Celia ^f   Cruz, Esperanza ^f   Pérez Luque, Elva ^g   Malacara, Juan Manuel ^f   Garay, Maria Eugenia ^g   Peralta Romero, Jesús ^h   Flores Huerta, Samuel ^b   García Mena, Jaime ^a   Froguel, Philippe ^c,d,i   Cruz, Miguel ^h   Bonnefond, Amélie ^c,d,j  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^c INSTITUT PASTEUR DE LILLE   (France)

^d UNIV LILLE   (France)

^e MCMASTER UNIVERSITY   (Canada)

^f UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^g UNIVERSITY OF GUANAJUATO   (Mexico)

^h INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

ⁱ HAMMERSMITH HOSPITAL   (United Kingdom)

^j INSERM   (France)

more..

Author keywords

Mexican children; Obesity; Single nucleotide polymorphism

Indexed keywords

CHOLESTEROL; ENPP1 PROTEIN; FTO PROTEIN; GLUCOSE; GNPDA2 PROTEIN; INSULIN; MC4R PROTEIN; NEGR1 PROTEIN; NPC1 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BODY MASS; CHILD; CHILDHOOD OBESITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; EUROPE; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MEXICO; PRESCHOOL CHILD; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ALDOSE-KETOSE ISOMERASES; ALLELES; BODY MASS INDEX; CARRIER PROTEINS; CELL ADHESION MOLECULES, NEURONAL; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GPI-LINKED PROTEINS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEXICO; OBESITY; PHOSPHORIC DIESTER HYDROLASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; PYROPHOSPHATASES; RECEPTOR, MELANOCORTIN, TYPE 4; RISK FACTORS;

EID: 84873044014     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-14-21     Document Type: Article

References (28)

1. Olaiz G, Rivera J, Shamah T, Rojas R, Villalpando S, Hernández M, Sepúlveda J. Encuesta Nacional de Salud y Nutrición 2006, Instituto Nacional de Salud Pública, Mexico City, Mexico.
2. Must A. Does overweight in childhood have an impact on adult health?. Nutr Rev 2003, 61(4):139-142. 10.1301/nr.2003.apr.139-142, 12795448.
3. Allison DB, Kaprio J, Korkeila M, Koskenvuo M, Neale MC, Hayakawa K. The heritability of body mass index among an international sample of monozygotic twins reared apart. Int J Obes Relat Metab Disord 1996, 20(6):501-506.
4. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, Alberiche M, Bonadonna RC, Muggeo M. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 1998, 47(10):1643-1649. 10.2337/diabetes.47.10.1643, 9753305.
5. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Magi R, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2011, 42(11):937-948.
6. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008, 40(6):768-775. 10.1038/ng.140, 2669167, 18454148.
7. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009, 41(1):25-34. 10.1038/ng.287, 2695662, 19079261.
8. Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005, 37(8):863-867. 10.1038/ng1604, 2000804, 16025115.
9. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proenca C, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009, 41(2):157-159. 10.1038/ng.301, 19151714.
10. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316(5826):889-894. 10.1126/science.1141634, 2646098, 17434869.
11. Dina C, Meyre D, Samson C, Tichet J, Marre M, Jouret B, Charles MA, Balkau B, Froguel P. Comment on " A common genetic variant is associated with adult and childhood obesity" Science 2007, 315(5809):187. author reply 187.
12. Rosskopf D, Bornhorst A, Rimmbach C, Schwahn C, Kayser A, Kruger A, Tessmann G, Geissler I, Kroemer HK, Volzke H. Comment on " A common genetic variant is associated with adult and childhood obesity" Science 2007, 315(5809):187. author reply 187.
13. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, et al. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 2007, 3(4):e61. 10.1371/journal.pgen.0030061, 1857727, 17465681.
14. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL. CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2000, 2002(246):1-190.
15. Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007, 120(Suppl 4):S164-S192.
16. Garcia Cuartero B, Garcia Lacalle C, Jimenez Lobo C, Gonzalez Vergaz A, Calvo Rey C, Alcazar Villar MJ, Diaz Martinez E. [The HOMA and QUICKI indexes, and insulin and C-peptide levels in healthy children. Cut off points to identify metabolic syndrome in healthy children]. An Pediatr (Barc) 2007, 66(5):481-490.
17. Juarez-Lopez C, Klunder-Klunder M, Medina-Bravo P, Madrigal-Azcarate A, Mass-Diaz E, Flores-Huerta S. Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents. BMC Public Health 2010, 10:318. 10.1186/1471-2458-10-318, 2898826, 20529295.
18. Cheung CY, Tso AW, Cheung BM, Xu A, Ong KL, Fong CH, Wat NM, Janus ED, Sham PC, Lam KS. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab 2010, 95(3):1395-1403. 10.1210/jc.2009-1465, 20061430.
19. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, et al. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia 2011, 54(6):1350-1359. 10.1007/s00125-011-2086-8, 21369819.
20. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, Hou D, Sun D, Ott J, Wang X, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes 2010, 59(12):3085-3089. 10.2337/db10-0273, 2992769, 20843981.
21. Loos RJ. Recent progress in the genetics of common obesity. Br J Clin Pharmacol 2009, 68(6):811-829. 10.1111/j.1365-2125.2009.03523.x, 2810793, 20002076.
22. Liang J, Fu M, Ciociola E, Chandalia M, Abate N. Role of ENPP1 on adipocyte maturation. PLoS One 2007, 2(9):e882. 10.1371/journal.pone.0000882, 1964519, 17849011.
23. Villalobos-Comparan M, Teresa Flores-Dorantes M, Teresa Villarreal-Molina M, Rodriguez-Cruz M, Garcia-Ulloa AC, Robles L, Huertas-Vazquez A, Saucedo-Villarreal N, Lopez-Alarcon M, Sanchez-Munoz F, et al. The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring) 2008, 16(10):2296-2301.
24. Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, Garver WS. Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance. Hum Mol Genet 2011, 20(2):312-321. 10.1093/hmg/ddq466, 3005903, 21036943.
25. den Hoed M, Luan J, Langenberg C, Cooper C, Sayer AA, Jameson K, Kumari M, Kivimaki M, Hingorani AD, Grontved A, et al. Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples. Int J Obes (Lond) 2012,
26. Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet 2009, 54(12):727-731. 10.1038/jhg.2009.106, 19851340.
27. Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012, 44(9):981-990. 10.1038/ng.2383, 3442244,3442244, 22885922.
28. Xi B, Takeuchi F, Chandak GR, Kato N, Pan HW, Zhou DH, Pan HY, Mi J. Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals. Diabetologia 2012, 55(10):2660-2666. 10.1007/s00125-012-2655-5, 22869321.