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Volumn 1305, Issue , 2013, Pages 64-75
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Isolation of monoclonal antibody from a Chinese hamster ovary supernatant. II: Dynamics of the integrated separation on ion exchange and hydrophobic interaction chromatography media
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Author keywords
Hydrophobic interaction chromatography; IgG1; Ion exchange chromatography; Mathematical modeling; Monoclonal antibody
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Indexed keywords
CHINESE HAMSTER OVARY;
CHROMATOGRAPHIC PROCESS;
HYDROPHOBIC INTERACTION CHROMATOGRAPHY;
IGG1;
ION EXCHANGE CHROMATOGRAPHY;
KINETIC AND THERMODYNAMIC PARAMETERS;
OPTIMIZATION ROUTINE;
PURIFICATION PROCESS;
CHROMATOGRAPHIC ANALYSIS;
COMPUTER SIMULATION;
LIQUID CHROMATOGRAPHY;
MATHEMATICAL MODELS;
MONOCLONAL ANTIBODIES;
OPTIMIZATION;
PROTEINS;
LOADING;
IMMUNOGLOBULIN G1;
MONOCLONAL ANTIBODY;
SODIUM CHLORIDE;
ACCURACY;
ADSORPTION KINETICS;
ANIMAL CELL;
ARTICLE;
CHO CELL;
CONCENTRATION (PARAMETERS);
DILUTION;
ELUTION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HYDROPHOBIC INTERACTION CHROMATOGRAPHY;
ION EXCHANGE CHROMATOGRAPHY;
MATHEMATICAL MODEL;
NONHUMAN;
PH;
POROSITY;
PREDICTION;
PRIORITY JOURNAL;
PROCESS OPTIMIZATION;
PROTEIN PURIFICATION;
SUPERNATANT;
THERMODYNAMICS;
HYDROPHOBIC INTERACTION CHROMATOGRAPHY;
IGG1;
ION EXCHANGE CHROMATOGRAPHY;
MATHEMATICAL MODELING;
MONOCLONAL ANTIBODY;
ADSORPTION;
ANIMALS;
ANTIBODIES, MONOCLONAL;
CALIBRATION;
CHO CELLS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CRICETINAE;
CRICETULUS;
HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;
MODELS, THEORETICAL;
CRICETULUS GRISEUS;
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EID: 84881312838
PISSN: 00219673
EISSN: 18733778
Source Type: Journal
DOI: 10.1016/j.chroma.2013.06.076 Document Type: Article |
Times cited : (19)
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References (47)
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