Adsorption of monoclonal antibody variants on analytical cation-exchange resin

Journal of Chromatography A

Volumn 1154, Issue 1-2, 2007, Pages 121-131

  Melter, Lena ^a   Ströhlein, Guido ^a   Butté, Alessandro ^a   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Double peaks; Equilibrium theory; Ion exchange chromatography; Lumped kinetic model; Modifier adsorption; Monoclonal antibody variants

Indexed keywords

ADSORPTION; ADSORPTION ISOTHERMS; CHARGE DISTRIBUTION; ION EXCHANGE RESINS; PH;

DOUBLE PEAKS; EQUILIBRIUM THEORY; ION-EXCHANGE CHROMATOGRAPHY; LUMPED KINETIC MODEL; MODIFIER ADSORPTION; MONOCLONAL ANTIBODY VARIANTS;

ANTIBODIES;

CATION EXCHANGE RESIN; MONOCLONAL ANTIBODY;

ADSORPTION KINETICS; ARTICLE; CONCENTRATION (PARAMETERS); DRUG DISTRIBUTION; DRUG IMPURITY; DRUG QUALITY; DRUG RETENTION; ELUTION; ION EXCHANGE CHROMATOGRAPHY; ISOTHERM; PH; PRIORITY JOURNAL; SEPARATION TECHNIQUE; VALIDATION PROCESS;

ADSORPTION; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, ION EXCHANGE; IMMUNOGLOBULIN VARIABLE REGION; ION EXCHANGE RESINS; LYSINE; MODELS, CHEMICAL;

EID: 34249717890     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.03.130     Document Type: Article

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