Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography

Journal of Chromatography A

Volumn 1253, Issue , 2012, Pages 32-43

  Guélat, Bertrand ^a   Ströhlein, Guido ^a,b   Lattuada, Marco ^a   Delegrange, Lydia ^c   Valax, Pascal ^c   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b CHROMACON AG   (Switzerland)

^c MERCK SERONO S A   (Switzerland)

Author keywords

Adsorption equilibrium; Ion exchange chromatography; Monoclonal antibody variants; PH gradient; Salt gradient; Simulation model

Indexed keywords

ADSORPTION EQUILIBRIA; ION-EXCHANGE CHROMATOGRAPHY; PH GRADIENTS; SALT GRADIENT; SIMULATION MODEL;

ADSORPTION ISOTHERMS; AMINO ACIDS; CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; SEPARATION;

COMPUTER SIMULATION;

AMINE; LYSINE; MONOCLONAL ANTIBODY; SODIUM CHLORIDE;

ADSORPTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODEL; CHEMICAL PARAMETERS; CONCENTRATION (PARAMETERS); DEAMINATION; DRUG SCREENING; ELUTION; ION EXCHANGE CHROMATOGRAPHY; ISOTHERM; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RELIABILITY; SIMULATION; VALIDATION STUDY;

ADSORPTION; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, ION EXCHANGE; COMPUTER SIMULATION; HYDROGEN-ION CONCENTRATION; KINETICS; PROTEIN ISOFORMS; SODIUM CHLORIDE; THERMODYNAMICS;

EID: 84864564777     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.081     Document Type: Article

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