Modeling shock layers in ion-exchange displacement chromatography

AIChE Journal

Volumn 45, Issue 1, 1999, Pages 27-37

  Natarajan, Venkatesh ^a   Cramer, Steven M ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; ION EXCHANGE; MASS TRANSFER; MATHEMATICAL MODELS; REACTION KINETICS; SEPARATION; THERMODYNAMICS;

ION EXCHANGE DISPLACEMENT CHROMATOGRAPHY;

CHROMATOGRAPHY;

CHROMATOGRAPHY; ION EXCHANGE; SHOCK;

ARTICLE; DISPERSION; FINITE ELEMENT ANALYSIS; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; MASS ACTION; MODEL; PARTICLE SIZE; SHOCK WAVE; THERMODYNAMICS; THICKNESS;

EID: 0032989013     PISSN: 00011541     EISSN: None     Source Type: Journal    
DOI: 10.1002/aic.690450104     Document Type: Article

References (34)

1. Arnold, F. H., H. W. Blanch, and C. R. Wilke, "Analysis of Affinity Separations: II. The Characterization of Affinity Columns by Pulse Techniques," Chem. Eng. J., 30, B25 (1985).
2. Boardman, N. K., and S. M. Partridge, "Separation of Neutral Proteins on Ion Exchange Resins," Biochem. J., 59, 543 (1955).
3. Brooks, C. A., and S. M. Cramer, "Steric Mass-Action Ion Exchange: Displacement Profiles and Induced Salt Gradients," AIChE J., 38, 1969 (1992).
4. Brooks, C. A., and S. M. Cramer, "Solute Affinity in Ion Exchange Displacement Chromatography," Chem. Eng. Sci., 51, 3847 (1996).
5. Cramer, S. M., and G. Subramaniam, "Preparative Liquid Chromatography of Biomolecules - New Directions," New Directions in Sorption Technology, E. G. Keller and R. T. Yang, eds., Butterworth, Stoneham, U.K. (1989).
6. Cysewski, P., A. Jaulmes, R. Lemque, B. Sebille, C. Vidal-Madjar, and G. Jilge, "Multivalent Ion Exchange Model of Biopolymer Chromatography for Mass Overload Conditions," J. Chromatog., 548, 61 (1991).
7. de Bernardo, S., M. Weigele, V. Toome, K. Manhart, and W. Leimgruber, "Studies on the Reaction of Fluorescamine with Primary Amines," Arch. Biochem. Biophy., 163, 390 (1974).
8. Gadam, S. D., G. Jayaraman, and S. M. Cramer, "Characterization of Non-Linear Adsorption Properties of Dextran-Based Polyelectrolyte Displacers in Ion-Exchange Systems," J. Chromatog., 630, 37 (1993).
9. Gadam, S. D., S. R. Gallant, and S. M. Cramer, "Transient Profiles in Ion Exchange Displacement Chromatography," AJChE J., 41, 1676 (1995).
10. Gallant, S. R., A. Kundu, and S. M. Cramer, "Modeling Non-Linear Elution of Proteins in Ion-Exchange Chromatography," J. Chromatog. A, 702, 125 (1995a).
11. Gallant, S. R., A. Kundu, and S. M. Cramer, "Optimization of Step Gradient Separations: Consideration of Nonlinear Adsorption," Biotechnol. & Bioeng., 47, 355 (1995b).
12. Gallant, S. R., S. Vunnum, and S. M. Cramer, "Optimization of Preparative Ion Exchange Chromatography of Proteins: Linear Gradient Separations," J. Chromatog. A, 725, 295 (1996).
13. Guiochon, G., S. G. Shirazi, and A. M. Katti, Fundamentals of Preparative and Nonlinear Chromatography, Academic Press, New York (1994).
14. Helfferich, F. G., and P. W. Carr, "Non-Linear Waves in Chromatography: I. Waves, Shocks, and Shapes," J. Chromatog., 629, 97 (1993).
15. Kopaciewicz, W., M. A. Rounds, J. Fausnaugh, and F. E. Regnier, "Retention Model for High-Performance Ion Exchange Chromatography," J. Chromatog., 266, 3 (1983).
16. Kundu, A., "Low Molecular Weight Displacers for Protein Purification in Ion Exchange Systems," PhD Diss., Rensselaer Polytechnic Inst., Troy, NY (1996).
17. Kundu, A., A. A. Shukla, K. A. Barnthouse, J. Moore, and S. M. Cramer, "Displacement Chromatography of Proteins Using Sucrose Octasulfate," BioPharm, 10, 64 (1997).
18. Kundu, A., and S. M. Cramer, "Low-Molecular-Weight Displacers for High-Resolution Protein Separations," Anal. Biochem., 248, 1 (1997).
19. Li, Y.-L., and N. G. Pinto, "Influence of Lateral Interactions on Preparative Protein Chromatography: I. Isotherm Behavior," J. Chromatog. A, 658, 445 (1994).
20. Phillips, M. W., G. Subramanian, and S. M. Cramer, "Theoretical Optimization of Operating Parameters in Non-Ideal Displacement Chromatography," J. Chromatog., 454, 1 (1988).
21. Raje, P., and N. G. Pinto, "Combination of the Steric Mass Action and Non-Ideal Surface Solution Models for Overload Protein Ion-Exchange Chromatography," J. Chromatog. A, 760, 89 (1997).
22. Rhee, H.-K., B. F. Bodin, and N. R. Amundson, "A Study of the Shock Layer in Equilibrium Exchange Systems," Chem. Eng. Sci., 26, 1571 (1971).
23. Rhee, H.-K., and N. R. Amundson, "A Study of the Shock Layer in Nonequilibrium Exchange Systems," Chan. Eng. Sci., 27, 199 (1972).
24. Rhee, H.-K., and N. R. Amundson, "Shock Layer in Two Solute Chromatography: Effect of Axial Dispersion and Mass Transfer," Chem. Eng. Sci., 29, 2049 (1974).
25. Rhee, H.-K., and N. R. Amundson, "Analysis of Multicomponent Separation by Displacement Development," AIChE J., 28, 423 (1982).
26. Shukla, A. A., K. A. Barnthouse, S. S. Bae, J. A. Moore, and S. M. Cramer, "Structural Characteristics of Low Molecular Mass Displaces for Cation Exchange Chromatography," J. Chromatog. A, 814, 83 (1998).
27. Udenfriend, S., S. Stein, P. Bohlen, and W. Dairman, "Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range," Science, 178, 871 (1972).
28. van Deemter, J. J., K. J. Zuiderweg, and A. Klinkerberg, "Longitudinal Diffusion and Resistance to Mass Transfer as Causes of Non-ideality in Chromatography," Chem. Eng. Sci., 5, 271 (1956).
29. Velayudhan, A., and Cs. Horvath, "Preparative Chromatography of Proteins. Analysis of the Multivalent Ion Exchange Formalism," J. Chromatog., 443, 13 (1988).
30. Velayudhan, A., "Studies in Nonlinear Chromatography," PhD Diss., Yale University, New Haven, CT (1990).
31. Whitley, R. D., R. Wachter, F. Liu, and N.-H. L. Wang. "Ion Exchange Equilibria of Lysozyme, Myoglobin, and Bovine Serum Albumin," J. Chromatog., 465, 137 (1989).
32. Zhu, J., Z. Ma. and G. Guiochon, "The Thickness of Shock Layers in Liquid Chromatography," Biotechnol. Prog., 9, 421 (1993).
33. Zhu, J., and G. Guiochon, "Shock Layer Thickness and Optimum Linear Velocity in Displacement Chromatography," J. Chromatog., 659, 15 (1994).
34. Zhu, J., and G. Guiochon, "Production Rate of an Isotachic Train in Displacement Chromatography," AIChE J., 41, 45 (1995).