Structural and functional analysis of angucycline C-6 ketoreductase lan v involved in landomycin biosynthesis

Biochemistry

Volumn 52, Issue 31, 2013, Pages 5304-5314

  Paananen, Pasi ^a   Patrikainen, Pekka ^a   Kallio, Pauli ^a   Mäntsälä, Pekka ^a   Niemi, Jarmo ^a   Niiranen, Laila ^a   Metsä Ketelä, Mikko ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC REACTIONS; CONFORMATIONAL CHANGE; COORDINATED WATER; HYDROPHOBIC INTERACTIONS; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATES; SHORT CHAIN ALCOHOLS; SITE DIRECTED MUTAGENESIS; SUBSTRATE RECOGNITION;

AMIDES; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CATALYST ACTIVITY; KETONES; STEREOCHEMISTRY;

STEREOSELECTIVITY;

ANGUCYCLINE DERIVATIVE; GAUDIMYCIN C; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OLEANDOMYCIN; PROTEIN LANV; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; REDUCTION; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STREPTOMYCES; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINOGLYCOSIDES; ANTHRAQUINONES; BACTERIAL PROTEINS; GLYCOSYLTRANSFERASES; MOLECULAR STRUCTURE; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84881247647     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400712q     Document Type: Article

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