Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis

Biochemistry

Volumn 50, Issue 24, 2011, Pages 5535-5543

  Kallio, Pauli ^a   Patrikainen, Pekka ^a   Suomela, Jukka Pekka ^a   Mäntsälä, Pekka ^a   Metsä Ketelä, Mikko ^a   Niemi, Jarmo ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC CYCLES; FLAVOENZYMES; HYDROXYLASES; IN-VITRO; IN-VIVO; KINETIC PROPERTIES; MULTI-STEP; OXYGEN ATOM; PRODUCT DEGRADATION; REACTION CASCADES; REACTION YIELDS; REACTIVE INTERMEDIATE; REDOX CASCADES; REDUCTASE GENES; SHORT CHAIN ALCOHOLS; SIMPLIFIED MODELS;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; ENZYMES; GENES; OXYGEN; REDOX REACTIONS;

REACTION INTERMEDIATES;

ALCOHOL DEHYDROGENASE; ANGUCYCLINE DERIVATIVE; FLAVOPROTEIN; FLAVOPROTEIN HYDROXYLASE PGAE; GAUDIMYCIN C; OXIDOREDUCTASE; OXYGEN; OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; DEGRADATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; MOLECULAR STABILITY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTUM YIELD;

ALCOHOL DEHYDROGENASE; ALCOHOL OXIDOREDUCTASES; ANTHRAQUINONES; BASE SEQUENCE; DNA, BACTERIAL; FLAVOPROTEINS; KINETICS; MIXED FUNCTION OXYGENASES; OXYGEN; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 79959274080     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200600k     Document Type: Article

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