The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients

Journal of Biological Chemistry

Volumn 288, Issue 30, 2013, Pages 21936-21944

  Sunahori, Katsue ^a   Nagpal, Kamalpreet ^a   Hedrich, Christian M ^a   Mizui, Masayuki ^a   Fitzgerald, Lisa M ^a   Tsokos, George C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SUBUNITS; DNA HYPOMETHYLATION; MITOGEN ACTIVATED PROTEIN KINASE; OVER-EXPRESSION; PROTEIN PATHWAYS; PROTEIN PHOSPHATASE 2A; SIGNAL-REGULATED KINASE; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACIDS; ENZYMES; PHOSPHORYLATION; PROTEINS;

T-CELLS;

AZATHIOPRINE; CELL DNA; DNA METHYLTRANSFERASE 1; HYDROXYCHLOROQUINE; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHOSPHOPROTEIN PHOSPHATASE 2A; PREDNISONE; SMALL INTERFERING RNA;

ADULT; ARTICLE; CATALYSIS; CD70 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

DNA METHYLATION; EPIGENETICS; ERK; PROTEIN PHOSPHATASE; SLE; T-CELL;

ADULT; ANTIGENS, CD70; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; IONOMYCIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; YOUNG ADULT;

EID: 84881246523     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.467266     Document Type: Article

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