Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 2005-2012

  Pimkaew, Prapapan ^a   Küblbeck, Jenni ^b   Petsalo, Aleksanteri ^b   Jukka, Jouni ^b   Suksamrarn, Apichart ^c   Juvonen, Risto ^b   Auriola, Seppo ^b   Piyachaturawat, Pawinee ^a   Honkakoski, Paavo ^b  

^a Mahidol University ^*  (Thailand)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c RAMKHAMHAENG UNIVERSITY   (Thailand)

Author keywords

Curcuma elata; Cytochrome P450; Induction; Inhibition; Sesquiterpenes; Toxicity

Indexed keywords

ANDROSTANE X RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; EPOXIDE; GERMACRONE; GLUTATHIONE; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SESQUITERPENE DERIVATIVE; STEROID RECEPTOR; UNCLASSIFIED DRUG; ZEDERONE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPHILICITY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; HERB DRUG INTERACTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL; LIVER MICROSOME; LIVER TOXICITY; METABOLITE; PROTEIN EXPRESSION;

1,4-BIS[2-(3,5-DICHLOROPYRIDYL-OXY)]BENZENE; 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE O-(3,4-DICHLORO-BENZYL)OXIME; ACETONITRILE; ACN; AHR; ARYL HYDROCARBON RECEPTOR; CAR; CITCO; CONSTITUTIVE ANDROSTANE RECEPTOR; CURCUMA ELATA; CYP; CYTOCHROME P450; DIMETHYL SULFOXIDE; DMSO; GAPDH; GLUTATHIONE (REDUCED); GLYSERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; GSH; HLM; HPH; HUMAN LIVER MICROSOMES; HUMAN PRIMARY HEPATOCYTE; INDUCTION; INHIBITION; LACTATE DEHYDROGENASE; LDH; MRM; MULTIPLE REACTION MONITORING; OME; OMEPRAZOLE; PCN; PHENYTOIN; PHN; PREGNANE X RECEPTOR; PREGNENOLONE-16Α-CARBONITRILE; PXR; RIF; RIFAMPICIN; SESQUITERPENES; TCP; TOXICITY;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CURCUMA; CYTOCHROME P-450 ENZYME SYSTEM; HEPATOCYTES; HERB-DRUG INTERACTIONS; HUMANS; MICE; MICROSOMES, LIVER; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RECOMBINANT PROTEINS; RNA, MESSENGER; SESQUITERPENES; SESQUITERPENES, GERMACRANE;

EID: 84881240685     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.07.004     Document Type: Article

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