Diarylheptanoid phytoestrogens isolated from the medicinal plant curcuma comosa: Biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms

Environmental Health Perspectives

Volumn 117, Issue 7, 2009, Pages 1155-1161

  Winuthayanon, Wipawee ^a,b   Piyachaturawat, Pawinee ^a   Suksamram, Apichart ^c   Ponglikitmongkol, Mathurose ^a   Arao, Yukitomo ^b   Hewitt, Sylvia C ^b   Korach, Kenneth S ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c RAMKHAMHAENG UNIVERSITY   (Thailand)

Author keywords

Curcuma comosa; Diarylheptanoid; ER dependent; ERE dependent; ERE independent; Estrogen regulated genes; Uterotrophic activity

Indexed keywords

1,7 DIPHENYL 4,6 HEPTADIEN 3 OL; 1,7 DIPHENYL 6 HEPTEN 3 OL; 1,7 DIPHENYL 6 HEPTEN 3 ONE; ACTIVATING TRANSCRIPTION FACTOR 1; ACTIVATING TRANSCRIPTION FACTOR 2; AQUAPORIN 5; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; HEPTANE DERIVATIVE; LACTOFERRIN; PHYTOESTROGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; CURCUMA COMOSA; CURCUMA LONGA; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENDOMETRIUM; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UPREGULATION; UTERUS WEIGHT; WILD TYPE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMA; DIARYLHEPTANOIDS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; ORGAN SIZE; OVARIECTOMY; PHYTOESTROGENS; PLANT EXTRACTS; PLANTS, MEDICINAL; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; TRANSCRIPTION, GENETIC; UTERUS;

CURCUMA COMOSA; MAMMALIA; MUS;

EID: 67651009206     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0900613     Document Type: Article

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