Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: A model of relevance to asthma

Clinical Science

Volumn 125, Issue 11, 2013, Pages 533-542

  Riley, Jason P ^a   Fuchs, Barbara ^b   Sjöberg, Lisa ^b   Nilsson, Gunnar P ^b   Karlsson, Lars ^a   Dahlén, Sven Erik ^b   Rao, Navin L ^a   Adner, Mikael ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Airway hyper responsiveness (AHR); Animal model; Asthma; Combination treatment; Early allergic reaction; Guinea pig; Mast cell

Indexed keywords

HISTAMINE; INDOMETACIN; LEUKOTRIENE; MEPYRAMINE; METHACHOLINE; MONTELUKAST; OVALBUMIN; PROSTANOID;

AIRWAY RESISTANCE; ALLERGIC ASTHMA; ALLERGIC REACTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BIOSYNTHESIS; BRONCHOSPASM; CONTROLLED STUDY; EXPERIMENTAL GUINEA PIG; HISTOLOGY; IN VIVO STUDY; LUNG FUNCTION; LUNG PARENCHYMA; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

ACETATES; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; GUINEA PIGS; HISTAMINE ANTAGONISTS; HYPERSENSITIVITY; INDOMETHACIN; LEUKOTRIENE ANTAGONISTS; LUNG; MAST CELLS; OVALBUMIN; PROSTAGLANDIN ANTAGONISTS; PYRILAMINE; QUINOLINES;

EID: 84881230114     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20130092     Document Type: Article

References (38)

1. Wardlaw, A. J., Brightling, C. E., Green, R., Woltmann, G., Bradding, P. and Pavord, I. D. (2002) New insights into the relationship between airway inflammation and asthma. Clin. Sci. 103, 201-211
2. Grainge, C. L., Lau, L. C., Ward, J. A., Dulay, V., Lahiff, G., Wilson, S., Holgate, S., Davies, D. E. and Howarth, P. H. (2011) Effect of bronchoconstriction on airway remodeling in asthma. N. Engl. J. Med. 364, 2006-2015
3. Lei, Y., Gregory, J. A., Nilsson, G. P. and Adner, M. (2013) Insights into mast cell functions in asthma using mouse models. Pulm. Pharmacol. Ther., doi: 10.1016/j.pupt.2013.03.019
4. Xing, W., Austen, K. F., Gurish, M. F. and Jones, T. G. (2011) Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc. Natl. Acad. Sci. U.S.A. 108, 14210-14215
5. Fuchs, B., Sjoberg, L., Moller Westerberg, C., Ekoff, M., Swedin, L., Dahlen, S. E., Adner, M. and Nilsson, G. P. (2012) Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model. Am. J. Physiol. Lung Cell. Mol. Physiol. 303, L1027-L1036
6. Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. (2010) Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulm. Pharmacol. Ther. 23, 300-307
7. Moffatt, J. D., Cocks, T. M. and Page, C. P. (2004) Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea. Br. J. Pharmacol. 141, 1159-1166
8. Stevenson, C. S. and Birrell, M. A. (2011) Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. Pharmacol. Ther. 130, 93-105
9. Holgate, S. T., Benyon, R. C., Howarth, P. H., Agius, R., Hardy, C., Robinson, C., Durham, S. R., Kay, A. B. and Church, M. K. (1985) Relationship between mediator release from human lung mast cells in vitro and in vivo. Int. Arch. Allergy Appl. Immunol. 77, 47-56
10. Bjorck, T. and Dahlen, S. E. (1993) Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. Pulm. Pharmacol. 6, 87-96
11. Beasley, R. C., Featherstone, R. L., Church, M. K., Rafferty, P., Varley, J. G., Harris, A., Robinson, C. and Holgate, S. T. (1989) Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. J. Appl. Physiol. 66, 1685-1693
12. Smith, L. J., Rubin, A. H. and Patterson, R. (1988) Mechanism of platelet activating factor-induced bronchoconstriction in humans. Am. Rev. Respir. Dis. 137, 1015-1019
13. Larsson, A. K., Hagfjard, A., Dahlen, S. E. and Adner, M. (2011) Prostaglandin D induces contractions through activation of TP receptors in peripheral lung tissue from the guinea pig. Eur. J. Pharmacol. 669, 136-142
14. Jonsson, E. W. and Dahlen, S. E. (1994) Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma. J. Pharmacol. Exp. Ther. 271, 615-623
15. Bandeira-Melo, C., Singh, Y., Cordeiro, R. S., e Silva, P. M. and Martins, M. A. (1996) Involvement of prostaglandins in the down-regulation of allergic plasma leakage observed in rats undergoing pleural eosinophilia. Br. J. Pharmacol. 118, 2192-2198
16. Cetinel, S., Canillioglu, Y. E., Cikler, E., Sener, G. and Ercan, F. (2011) Leukotriene D4 receptor antagonist montelukast alleviates protamine sulphate-induced changes in rat urinary bladder. BJU Int. 107, 1320-1325
17. Mukaiyama, O., Morimoto, K., Nosaka, E., Takahashi, S. and Yamashita, M. (2004) Greater involvement of neurokinins found in guinea pig models of severe asthma compared with mild asthma. Int. Arch. Allergy Immunol. 134, 263-272
18. Back, M., Kumlin, M., Cotgreave, I. A. and Dahlen, S. E. (2001) An alternative pathway for metabolism of leukotriene D4: effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. Br. J. Pharmacol. 133, 1134-1144
19. Nagai, H., Tsuji, F., Inagaki, N., Kitagaki, K., Fukutomi, O., Koda, A. and Daikoku, M. (1991) The effect of ONO-3708, a novel TxA2 receptor antagonist, on U-46619-induced contraction of guinea pig and human tracheal strips in vitro and on bronchoconstriction in guinea pigs in vivo. Prostaglandins 41, 375-382
20. Dahlen, S. E. (2006) Treatment of asthma with antileukotrienes: first line or last resort therapy? Eur. J. Pharmacol. 533, 40-56
21. Schmidt, D. and Rabe, K. F. (2000) The role of leukotrienes in the regulation of tone and responsiveness in isolated human airways. Am. J. Respir. Crit. Care Med. 161, S62-S67
22. Sundstrom, E., Lastbom, L., Ryrfeldt, A. and Dahlen, S. E. (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J. Pharmacol. Exp. Ther. 307, 408-418
23. Roquet, A., Dahlen, B., Kumlin, M., Ihre, E., Anstren, G., Binks, S. and Dahlen, S. E. (1997) Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics. Am. J. Respir. Crit. Care Med. 155, 1856-1863
24. Davis, B. E., Todd, D. C. and Cockcroft, D. W. (2005) Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen. J. Allergy Clin. Immunol. 116, 768-772
25. Richter, K., Gronke, L., Janicki, S., Maus, J., Jorres, R. A. and Magnussen, H. (2008) Effect of azelastine, montelukast, and their combination on allergen-induced bronchoconstriction in asthma. Pulm. Pharmacol. Ther. 21, 61-66
26. Safholm, J., Dahlen, S. E., Delin, I., Maxey, K., Stark, K., Cardell, L. O. and Adner, M. (2013) PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors. Br. J. Pharmacol. 168, 794-806
27. Ressmeyer, A. R., Larsson, A. K., Vollmer, E., Dahlen, S. E., Uhlig, S. and Martin, C. (2006) Characterisation of guinea pig precision-cut lung slices: comparison with human tissues. Eur. Respir. J. 28, 603-611
28. Matsumoto, T., Ashida, Y. and Tsukuda, R. (1994) Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig. J. Pharmacol. Exp. Ther. 269, 1236-1244
29. Mizutani, N., Inui, S., Yoshino, S. and Nabe, T. (2010) Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs. Biol. Pharm. Bull. 33, 1949-1952
30. Park, J. K., Kim, Y. K., Lee, S. R., Cho, S. H., Min, K. U. and Kim, Y. Y. (2001) Repeated exposure to low levels of sulfur dioxide (SO2) enhances the development of ovalbumin-induced asthmatic reactions in guinea pigs. Ann. Allergy Asthma Immunol. 86, 62-67
31. Smith, N. and Broadley, K. J. (2007) Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma. Int. Immunopharmacol. 7, 183-190
32. Bates, J., Irvin, C., Brusasco, V., Drazen, J., Fredberg, J., Loring, S., Eidelman, D., Ludwig, M., Macklem, P., Martin, J. et al. (2004) The use and misuse of Penh in animal models of lung disease. Am. J. Respir. Cell Mol. Biol. 31, 373-374
33. Andersson, C. K., Mori, M., Bjermer, L., Lofdahl, C. G. and Erjefalt, J. S. (2009) Novel site-specific mast cell subpopulations in the human lung. Thorax 64, 297-305
34. Dolovich, J., Hargreave, F. E., Jordana, M. and Denburg, J. (1989) Late-phase airway reaction and inflammation. J. Allergy Clin. Immunol. 83, 521-524
35. Iijima, H., Ishii, M., Yamauchi, K., Chao, C. L., Kimura, K., Shimura, S., Shindoh, Y., Inoue, H., Mue, S. and Takishima, T. (1987) Bronchoalveolar lavage and histologic characterization of late asthmatic response in guinea pigs. Am. Rev. Respir. Dis. 136, 922-929
36. Church, M. K., Hutson, P. A. and Holgate, S. T. (1993) Nedocromil sodium blocks the early and late phases of allergen challenge in a guinea pig model of asthma. J. Allergy Clin. Immunol. 92, 177-182
37. Bousquet, J., Emonot, A., Germouty, J., Molina, C., Montane, F., Perrin-Fayolle, M., Prud'homme, A., Sabbah, A., Taytard, A., Dupont, P. et al. (1990) Double-blind multicenter study of cetirizine in grass-pollen-induced asthma. Ann. Allergy 65, 504-508
38. Reicin, A., White, R., Weinstein, S. F., Finn, A. F., Jr., Nguyen, H., Peszek, I., Geissler, L. and Seidenberg, B. C. (2000) Montelukast, a leukotriene receptor antagonist, in combination with loratadine, a histamine receptor antagonist, in the treatment of chronic asthma. Arch. Intern. Med. 160, 2481-2488