PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP 2 receptors

British Journal of Pharmacology

Volumn 168, Issue 4, 2013, Pages 794-806

  Safholm J ^a   Dahlen S E ^a   Delin, I ^a   Maxey, K ^b   Stark, K ^a   Cardell, L O ^a   Adner, M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Cayman Chemical   (United States)

Author keywords

airway smooth muscle; EP 1; EP2; EP3; EP4; guinea pig; PGE2; spontaneous tone; trachea

Indexed keywords

11 FLUORO 9,15 DIHYDROXY 15 (2 INDANYL) 16,17,18,19,20 PENTANORPROSTA 5,13 DIENOIC ACID; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; CAY 10441; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; DICLOFENAC; ETORICOXIB; FR 122047; IBUPROFEN; INDOMETACIN; LUMIRACOXIB; MESSENGER RNA; ONO 8130; ONO AE 3 208; ONO AE 5 599; PF 04418948; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; TRACHEA MUSCLE; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; IN VITRO STUDY; MUSCLE CONTRACTION; MUSCLE TONE; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; TRACHEA;

ANIMALS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MALE; MUSCLE CONTRACTION; MUSCLE TONUS; MUSCLE, SMOOTH; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RNA, MESSENGER; SPECIES SPECIFICITY; TRACHEA;

MLCS; MLOWN;

EID: 84872924023     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02189.x     Document Type: Article

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