Cyclosporine A Impairs the Macrophage Reverse Cholesterol Transport in Mice by Reducing Sterol Fecal Excretion

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Zanotti, Ilaria ^a   Greco, Daniela ^a   Lusardi, Giulia ^a   Zimetti, Francesca ^a   Potì, Francesco ^b   Arnaboldi, Lorenzo ^c   Corsini, Alberto ^c   Bernini, Franco ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER G1; APOLIPOPROTEIN E; ATP BINDING CASSETTE G5; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLOSPORIN A; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE PROTEIN; SITOSTEROL; STEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; BILE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; FECES; GENE EXPRESSION; IN VIVO STUDY; INTESTINE ABSORPTION; LIVER WEIGHT; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL PROCEDURES; PLASMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOACTIVITY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE CHOLESTEROL TRANSPORT; STEROL EXCRETION;

EID: 84881220206     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071572     Document Type: Article

References (32)

1. Miller LW, (2002) Cardiovascular toxicities of immunosuppressive agents. Am J Transplant 2: 807-818.
2. Taylor AL, Watson CJ, Bradley JA, (2005) Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy. Crit Rev Oncol Hematol 56: 23-46.
3. Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, et al. (2012) Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 125: 1905-1919.
4. Cuchel M, Rader DJ, (2006) Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation 113: 2548-2555.
5. Rader DJ, Alexander ET, Weibel GL, Billheimer J, Rothblat GH, (2009) The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res 50Suppl: S189-194.
6. Emeson EE, Shen ML, (1993) Accelerated atherosclerosis in hyperlipidemic C57BL/6 mice treated with cyclosporin A. Am J Pathol. 142: 1906-1915.
7. Basu SK, Goldstein JL, Anderson GW, Brown MS, (1976) Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci U S A 73: 3178-3182.
8. Zanotti I, Favari E, Bernini F, (2012) Cellular Cholesterol Efflux Pathways: Impact on Intracellular Lipid Trafficking and Methodological Considerations. Curr Pharm Biotechnol 13: 292-302.
9. Iverson SJ, Lang SL, Cooper MH, (2001) Comparison of the Bligh and Dyer and Folch methods for total lipid determination in a broad range of marine tissue. Lipids 36: 1283-1287.
10. Batta AK, Salen G, Rapole KR, Batta M, Batta P, et al. (1999) Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. J Lipid Res 40: 1148-1154.
11. Zanotti I, Maugeais C, Pedrelli M, Gomaraschi M, Salgam P, et al. (2011) The thienotriazolodiazepine Ro 11-1464 increases plasma apoA-I and promotes reverse cholesterol transport in human apoA-I transgenic mice. Br J Pharmacol 164: 1642-1651.
12. Zheng XL, Wong NC, (2006) Cyclosporin A inhibits apolipoprotein AI gene expression. J Mol Endocrinol 37: 367-373.
13. Kockx M, Guo DL, Traini M, Gaus K, Kay J, et al. (2009) Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway. J Biol Chem 284: 24144-24154.
14. Le Goff W, Peng DQ, Settle M, Brubaker G, Morton RE, et al. (2004) Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I. Arterioscler Thromb Vasc Biol 24: 2155-2161.
15. Ye D, Hoekstra M, Out R, Meurs I, Kruijt JK, et al. (2008) Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice. Atherosclerosis 196: 650-658.
16. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
17. Huang ZH, Lin CY, Oram JF, Mazzone T, (2001) Sterol efflux mediated by endogenous macrophage ApoE expression is independent of ABCA1. Arterioscler Thromb Vasc Biol 21: 2019-2025.
18. Fitzgerald ML, Mujawar Z, Tamehiro N, (2010) ABC transporters, atherosclerosis and inflammation. Atherosclerosis 211: 361-370.
19. Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, et al. (2007) Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters. Biosci Biotechnol Biochem 71: 1886-1895.
20. Sabeva NS, Liu J, Graf GA, (2009) The ABCG5 ABCG8 sterol transporter and phytosterols: implications for cardiometabolic disease. Curr Opin Endocrinol Diabetes Obes 16: 172-177.
21. Oram JF, Vaughan AM, (2006) ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ Res 99: 1031-1043.
22. Yu L, Hammer RE, Li-Hawkins J, Von Bergmann K, Lutjohann D, et al. (2002) Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A 99: 16237-16242.
23. Vaziri ND, Liang K, Azad H, (2000) Effect of cyclosporine on HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, HDL receptor, VLDL receptor, and lipoprotein lipase expressions. J Pharmacol Exp Ther 294: 778-783.
24. Gueguen Y, Ferrari L, Souidi M, Batt AM, Lutton C, et al. (2007) Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase. Basic Clin Pharmacol Toxicol 100: 392-397.
25. van der Velde AE, Brufau G, Groen AK, (2010) Transintestinal cholesterol efflux. Curr Opin Lipidol 21: 167-171.
26. Escola-Gil JC, Llaverias G, Julve J, Jauhiainen M, Mendez-Gonzalez J, et al. (2011) The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway. Arterioscler Thromb Vasc Biol 31: 2493-2499.
27. Nishimoto T, Pellizzon MA, Aihara M, Stylianou IM, Billheimer JT, et al. (2009) Fish oil promotes macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol 29: 1502-1508.
28. Oram JF, (2002) ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol 13: 373-381.
29. Ye D, Lammers B, Zhao Y, Meurs I, Van Berkel TJ, et al. (2011) ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets for the treatment of atherosclerosis. Curr Drug Targets 12: 647-660.
30. Wang X, Collins HL, Ranalletta M, Fuki IV, Billheimer JT, et al. (2007) Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117: 2216-2224.
31. Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader DJ, et al. (2007) The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48: 2453-2462.
32. Zanotti I, Pedrelli M, Poti F, Stomeo G, Gomaraschi M, et al. (2011) Macrophage, but not systemic, apolipoprotein E is necessary for macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol 31: 74-80.