Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N- (thiazole-2-yl)acetamide derivatives and their anticancer activities

Medicinal Chemistry Research

Volumn 22, Issue 9, 2013, Pages 4110-4124

  Duran, Murat ^a   Demirayak, Şeref ^b  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b ISTANBUL MEDIPOL UNIVERSITY   (Turkey)

Author keywords

Acetamide; Anticancer; Imidazole; Melanoma; Thiazole

Indexed keywords

2 [1 (4 CHLOROPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (4 METHYLTHIAZOL 2 YL)ACETAMIDE; 2 [1 (4 CHLOROPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (THIAZOL 2 YL)ACETAMIDE; 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (4 METHYLTHIAZOL 2 YL)ACETAMIDE; 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (4 NITROTHIAZOL 2 YL)ACETAMIDE; 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO] N (THIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 METHYLTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 NITROTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (THIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO] N [4 (4 METHOXYPHENYL)THIAZOL 2 YL]ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 METHYLTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 NITROTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4 PHENYLTHIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (THIAZOL 2 YL)ACETAMIDE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N (THIAZOLE 2 YL)ACETAMIDE DERIVATIVE; 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO] N [4 (4METHOXYPHENYL)THIAZOL 2 YL)ACETAMIDE; ACETAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; ETHYL 2 [2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO]ACETAMIDO]THIAZOLE 4 CARBOXYLATE; ETHYL 2 [2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO]ACETAMIDO]THIAZOLE 4 CARBOXYLATE; ETHYL 2 [2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO]ACETAMIDO]THIAZOLE 4 CARBOXYLATE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO]ACETAMIDE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] 2 [4,5 DIMETHYL 1 (PARA TOLYLAMINO) 1H IMIDAZOL 2 YLTHIO]ACETAMIDE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] 2 [4,5 DIMETHYL 1 (PHENYLAMINO) 1H IMIDAZOL 2 YLTHIO]ACETAMIDE; N [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 [1 (4 METHOXYPHENYLAMINO) 4,5 DIMETHYL 1H IMIDAZOL 2 YLTHIO]ACETAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 84881139557     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0411-5     Document Type: Article

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