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Volumn 3, Issue 10, 2010, Pages 995-1000

Clopidogrel pharmacogenomics: Next steps: A clinical algorithm, gene-gene interactions, and an elusive outcomes trial

Author keywords

clopidogrel; personalized medicine; pharmacogenomics

Indexed keywords

AZATHIOPRINE; CLOPIDOGREL; PRASUGREL; WARFARIN;

EID: 77958559512     PISSN: 19368798     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcin.2010.08.012     Document Type: Review
Times cited : (6)

References (39)
  • 2
    • 33749321054 scopus 로고    scopus 로고
    • CYP2C19 (*)2 polymorphism contributes to a diminished pharmacodynamic response to clopidogrel (abstr)
    • T. Brandt, S. Kirkwood, and N. Mukhopadhyay CYP2C19 (*)2 polymorphism contributes to a diminished pharmacodynamic response to clopidogrel (abstr) J Am Coll Cardiol 47 Suppl 2006 380A
    • (2006) J Am Coll Cardiol , vol.47 , Issue.SUPPL.
    • Brandt, T.1    Kirkwood, S.2    Mukhopadhyay, N.3
  • 3
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • J.L. Mega, S.L. Close, and S.D. Wiviott Cytochrome p-450 polymorphisms and response to clopidogrel N Engl J Med 360 2009 354 362
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 4
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • J.L. Mega, S.L. Close, and S.D. Wiviott Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes Circulation 119 2009 2553 2560
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 5
    • 34548858712 scopus 로고    scopus 로고
    • Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects
    • P. Fontana, J.S. Hulot, P. De Moerloose, and P. Gaussem Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects J Thromb Haemost 5 2007 2153 2155
    • (2007) J Thromb Haemost , vol.5 , pp. 2153-2155
    • Fontana, P.1    Hulot, J.S.2    De Moerloose, P.3    Gaussem, P.4
  • 6
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • J.T. Brandt, S.L. Close, and S.J. Iturria Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel J Thromb Haemost 5 2007 2429 2436
    • (2007) J Thromb Haemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3
  • 7
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance
    • K.A. Kim, P.W. Park, S.J. Hong, and J.Y. Park The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance Clin Pharmacol Ther 84 2008 236 242
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 8
    • 47649111604 scopus 로고    scopus 로고
    • The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects
    • K. Umemura, T. Furuta, and K. Kondo The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects J Thromb Haemost 6 2008 1439 1441
    • (2008) J Thromb Haemost , vol.6 , pp. 1439-1441
    • Umemura, K.1    Furuta, T.2    Kondo, K.3
  • 9
    • 46849122018 scopus 로고    scopus 로고
    • Inhibition of ADP-induced platelet aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms
    • B.L. Chen, W. Zhang, and Q. Li Inhibition of ADP-induced platelet aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms Clin Exp Pharmacol Physiol 35 2008 904 908
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 904-908
    • Chen, B.L.1    Zhang, W.2    Li, Q.3
  • 10
    • 33846600867 scopus 로고    scopus 로고
    • Paving the critical path: How can clinical pharmacology help achieve the vision?
    • L.J. Lesko Paving the critical path: how can clinical pharmacology help achieve the vision? Clin Pharmacol Ther 81 2007 170 177
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 170-177
    • Lesko, L.J.1
  • 11
    • 34250638541 scopus 로고    scopus 로고
    • Pharmacometrics at FDA: Evolution and impact on decisions
    • J.R. Powell, and J.V. Gobburu Pharmacometrics at FDA: evolution and impact on decisions Clin Pharmacol Ther 82 2007 97 102
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 97-102
    • Powell, J.R.1    Gobburu, J.V.2
  • 13
    • 77953914576 scopus 로고    scopus 로고
    • The case for routine genotyping in dual-antiplatelet therapy
    • S.B. Damani, and E.J. Topol The case for routine genotyping in dual-antiplatelet therapy J Am Coll Cardiol 56 2010 109 111
    • (2010) J Am Coll Cardiol , vol.56 , pp. 109-111
    • Damani, S.B.1    Topol, E.J.2
  • 14
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19 (*)2 loss-of-function allele or proton pump inhibitor coadministration: A systematic meta-analysis
    • J.S. Hulot, J.P. Collet, and J. Silvain Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19 (*)2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis J Am Coll Cardiol 56 2010 134 143
    • (2010) J Am Coll Cardiol , vol.56 , pp. 134-143
    • Hulot, J.S.1    Collet, J.P.2    Silvain, J.3
  • 15
    • 79957485944 scopus 로고    scopus 로고
    • Cytochrome P450 2C19( (*))2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: A meta-analysis
    • F. Sofi, B. Giusti, R. Marcucci, A.M. Gori, R. Abbate, and G.F. Gensini Cytochrome P450 2C19( (*))2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis Pharmacogenomics J 2010 Mar 30 [E-pub ahead of print]
    • (2010) Pharmacogenomics J
    • Sofi, F.1    Giusti, B.2    Marcucci, R.3    Gori, A.M.4    Abbate, R.5    Gensini, G.F.6
  • 16
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • A.R. Shuldiner, J.R. O'Connell, and K.P. Bliden Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy JAMA 302 2009 849 857
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 17
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • FAST-MI Investigators
    • T. Simon, C. Verstuyft, M. Mary-Krause FAST-MI Investigators Genetic determinants of response to clopidogrel and cardiovascular events N Engl J Med 360 2009 363 375
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 18
    • 58249135635 scopus 로고    scopus 로고
    • L Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • J.P. Collet, J.S. Hulot, and A. Pena L Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study Lancet 373 2009 309 317
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 19
    • 65249145201 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    • D. Sibbing, J. Stegherr, and W. Latz Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention Eur Heart J 30 2009 916 922
    • (2009) Eur Heart J , vol.30 , pp. 916-922
    • Sibbing, D.1    Stegherr, J.2    Latz, W.3
  • 20
    • 61349191612 scopus 로고    scopus 로고
    • Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
    • B. Giusti, A.M. Gori, and R. Marcucci Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis Am J Cardiol 103 2009 806 811
    • (2009) Am J Cardiol , vol.103 , pp. 806-811
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3
  • 21
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • D. Trenk, W. Hochholzer, and M.F. Fromm Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents J Am Coll Cardiol 51 2008 1925 1934
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3
  • 22
    • 70449509294 scopus 로고    scopus 로고
    • Pharmacogenetic testing for clopidogrel using the rapid INFINITI analyzer: A dose-escalation study
    • P. Gladding, H. White, and J. Voss Pharmacogenetic testing for clopidogrel using the rapid INFINITI analyzer: a dose-escalation study J Am Coll Cardiol Intv 2 2009 1095 1101
    • (2009) J Am Coll Cardiol Intv , vol.2 , pp. 1095-1101
    • Gladding, P.1    White, H.2    Voss, J.3
  • 23
    • 62549101321 scopus 로고    scopus 로고
    • Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: Results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients with Clopidogrel Resistance) randomized study
    • Y.H. Jeong, S.W. Lee, and B.R. Choi Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) randomized study J Am Coll Cardiol 53 2009 1101 1109
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1101-1109
    • Jeong, Y.H.1    Lee, S.W.2    Choi, B.R.3
  • 24
    • 41249093357 scopus 로고    scopus 로고
    • Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study
    • L. Bonello, L. Camoin-Jau, and S. Arques Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study J Am Coll Cardiol 51 2008 1404 1411
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1404-1411
    • Bonello, L.1    Camoin-Jau, L.2    Arques, S.3
  • 25
    • 57549099501 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: A prospective, randomized study
    • T. Cuisset, C. Frere, and J. Quilici Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study J Am Coll Cardiol Intv 1 2008 649 653
    • (2008) J Am Coll Cardiol Intv , vol.1 , pp. 649-653
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 26
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2C19 loss-of-function polymorphism and of Major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • W. Hochholzer, D. Trenk, and M.F. Fromm Impact of cytochrome P450 2C19 loss-of-function polymorphism and of Major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement J Am Coll Cardiol 55 2010 2427 2434
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2427-2434
    • Hochholzer, W.1    Trenk, D.2    Fromm, M.F.3
  • 27
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19 2 loss of function polymorphism
    • L. Bonello, S. Armero, and O. Ait Mokhtar Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19 2 loss of function polymorphism J Am Coll Cardiol 2010 Jul 30 [E-pub ahead of print]
    • (2010) J Am Coll Cardiol
    • Bonello, L.1    Armero, S.2    Ait Mokhtar, O.3
  • 28
  • 29
    • 42149188553 scopus 로고    scopus 로고
    • CYP4F2 genetic variant alters required warfarin dose
    • M.D. Caldwell, T. Awad, and J.A. Johnson CYP4F2 genetic variant alters required warfarin dose Blood 111 2008 4106 4112
    • (2008) Blood , vol.111 , pp. 4106-4112
    • Caldwell, M.D.1    Awad, T.2    Johnson, J.A.3
  • 30
    • 73049117322 scopus 로고    scopus 로고
    • Ability of VKORC1 and CYP2C9 to predict therapeutic warfarin dose during the initial weeks of therapy
    • N.S. Ferder, C.S. Eby, and E. Deych Ability of VKORC1 and CYP2C9 to predict therapeutic warfarin dose during the initial weeks of therapy J Thromb Haemost 8 2010 95 100
    • (2010) J Thromb Haemost , vol.8 , pp. 95-100
    • Ferder, N.S.1    Eby, C.S.2    Deych, E.3
  • 31
    • 23644437525 scopus 로고    scopus 로고
    • Common VKORC1 and GGCX polymorphisms associated with warfarin dose
    • M. Wadelius, L.Y. Chen, and K. Downes Common VKORC1 and GGCX polymorphisms associated with warfarin dose Pharmacogenomics J 5 2005 262 270
    • (2005) Pharmacogenomics J , vol.5 , pp. 262-270
    • Wadelius, M.1    Chen, L.Y.2    Downes, K.3
  • 32
    • 77953917341 scopus 로고    scopus 로고
    • ABCB1 genetic variants, pharmacodynamic response, and cardiovascular outcomes following treatment with clopidogrel and PRASUGREL
    • J. Mega, C. Sandra, and D. Stephen ABCB1 genetic variants, pharmacodynamic response, and cardiovascular outcomes following treatment with clopidogrel and PRASUGREL J Am Coll Cardiol 55 Suppl A 2010 A113
    • (2010) J Am Coll Cardiol , vol.55 , Issue.SUPPL. A , pp. 113
    • Mega, J.1    Sandra, C.2    Stephen, D.3
  • 33
    • 53849083819 scopus 로고    scopus 로고
    • CYP2C19 pharmacogenetics in advanced cancer: Compromised function independent of genotype
    • N.A. Helsby, W.Y. Lo, and K. Sharples CYP2C19 pharmacogenetics in advanced cancer: compromised function independent of genotype Br J Cancer 99 2008 1251 1255
    • (2008) Br J Cancer , vol.99 , pp. 1251-1255
    • Helsby, N.A.1    Lo, W.Y.2    Sharples, K.3
  • 34
    • 68249152634 scopus 로고    scopus 로고
    • Pheno- or genotype for the CYP2C19 drug metabolism polymorphism: The influence of disease
    • N.A. Helsby Pheno- or genotype for the CYP2C19 drug metabolism polymorphism: the influence of disease Proc West Pharmacol Soc 51 2008 5 10
    • (2008) Proc West Pharmacol Soc , vol.51 , pp. 5-10
    • Helsby, N.A.1
  • 35
    • 34848828243 scopus 로고    scopus 로고
    • Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes
    • K. Kojima, K. Nagata, T. Matsubara, and Y. Yamazoe Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes Drug Metab Pharmacokinet 22 2007 276 286
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 276-286
    • Kojima, K.1    Nagata, K.2    Matsubara, T.3    Yamazoe, Y.4
  • 36
    • 7644238430 scopus 로고    scopus 로고
    • Use of laboratory testing to guide 6-mercaptopurine/azathioprine therapy
    • G.R. Lichtenstein Use of laboratory testing to guide 6-mercaptopurine/ azathioprine therapy Gastroenterology 127 2004 1558 1564
    • (2004) Gastroenterology , vol.127 , pp. 1558-1564
    • Lichtenstein, G.R.1
  • 37
    • 77955603691 scopus 로고    scopus 로고
    • Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: Initial evidence of a therapeutic window
    • D. Sibbing, S.R. Steinhubl, S. Schulz, A. Schomig, and A. Kastrati Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: initial evidence of a therapeutic window J Am Coll Cardiol 56 2010 317 318
    • (2010) J Am Coll Cardiol , vol.56 , pp. 317-318
    • Sibbing, D.1    Steinhubl, S.R.2    Schulz, S.3    Schomig, A.4    Kastrati, A.5
  • 38
    • 55449137355 scopus 로고    scopus 로고
    • CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • T. Geisler, E. Schaeffeler, and J. Dippon CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation Pharmacogenomics 9 2008 1251 1259
    • (2008) Pharmacogenomics , vol.9 , pp. 1251-1259
    • Geisler, T.1    Schaeffeler, E.2    Dippon, J.3
  • 39
    • 64049096916 scopus 로고    scopus 로고
    • The microeconomics of personalized medicine: Today's challenge and tomorrow's promise
    • J.C. Davis, L. Furstenthal, and A.A. Desai The microeconomics of personalized medicine: today's challenge and tomorrow's promise Nat Rev Drug Discov 8 2009 279 286
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 279-286
    • Davis, J.C.1    Furstenthal, L.2    Desai, A.A.3


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