Genetically modified whole-cell bioreporters for environmental assessment

Ecological Indicators

Volumn 28, Issue , 2013, Pages 125-141

  Xu, Tingting ^a   Close, Dan M ^b   Sayler, Gary S ^a,b   Ripp, Steven ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Bioluminescence; Bioremediation; Bioreporter; Ecotoxicology; Fluorescence

Indexed keywords

BIOCHEMISTRY; BIOLUMINESCENCE; BIOREMEDIATION; ECOLOGY; FLUORESCENCE; TOXICITY;

BIOREPORTER; CHEMICAL CONTAMINANTS; COLORIMETRIC SIGNALING; ECO-TOXICOLOGY; ENVIRONMENTAL APPLICATIONS; ENVIRONMENTAL ASSESSMENT; ENVIRONMENTAL MONITORING; GENETICALLY MODIFIED;

ENVIRONMENTAL TECHNOLOGY;

BACTERIUM; BIOAVAILABILITY; BIOINDICATOR; BIOLUMINESCENCE; BIOREMEDIATION; ECOTOXICOLOGY; ENVIRONMENTAL ASSESSMENT; ENVIRONMENTAL MONITORING; EUKARYOTE; FLUORESCENCE; GENETICALLY MODIFIED ORGANISM;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 84881119420     PISSN: 1470160X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecolind.2012.01.020     Document Type: Article

References (186)

1. Abd-El-Haleem, D., Ripp, S., Scott, C., Sayler, G.S., 2002. A luxCDABE-based bioluminescent bioreporter for the detection of phenol. J. Ind. Microbiol. Biotechnol. 29, 233-237. (Pubitemid 35379592)
2. Abd-El-Haleem, D., Ripp, S., Zaki, S., Sayler, G.S., 2007. Detection of nitrate/nitrite bioavailability in wastewater using a luxCDABE-based Klebsiella oxytoca bioluminescent bioreporter. J. Microbiol. Biotechnol. 17, 1254-1261. (Pubitemid 47377391)
3. Abd-El-Haleem, D., Zaki, S., Abulhamd, A., Elbery, H., Abu-Elreesh, G., 2006. Acinetobacter bioreporter assessing heavy metals toxicity. J. Basic Microbiol. 46, 339-347. (Pubitemid 44582316)
4. Amaro, F., Turkewitz, A.P., Martin-Gonzalez, A., Gutierrez, J.-C., 2011. Whole-cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila. Microb. Biotechnol. 4, 513-522.
5. Aminhanjani, S., Meikle, A., Glover, L.A., Prosser, J.I., Killham, K., 1993. Plasmid and chromosomally encoded luminescence marker systems for detection of Pseudomonas fluorescens in soil. Mol. Ecol. 2, 47-54.
6. Andersson, E., Rotander, A., von Kronhelm, T., Berggren, A., Ivarsson, P., Hollert, H., Engwall, M., 2009. AhR agonist and genotoxicant bioavailability in a PAHcontaminated soil undergoing biological treatment. Environ. Sci. Pollut. Res. 16, 521-530.
7. Aneck-Hahn, N.H., Bornman, M.S., de Jager, C., 2008. Preliminary assessment of oestrogenic activity in water sources in Rietvlei Nature Reserve, Gauteng, South Africa. Afr. J. Aquat. Sci. 33, 249-254.
8. Applegate, B., Kelly, C., Lackey, L., McPherson, J., Kehrmeyer, S., Menn, F.M., Bienkowski, P., Sayler, G., 1997. Pseudomonas putida B2: a tod-lux bioluminescent reporter for toluene and trichloroethylene co-metabolism. J. Ind. Microbiol. Biotechnol. 18, 4-9.
9. Applegate, B.M., Kehrmeyer, S.R., Sayler, G.S., 1998. A chromosomally based todluxCDABE whole-cell reporter for benzene, toluene, ethybenzene, and xylene (BTEX) sensing. Appl. Environ. Microbiol. 64, 2730-2735. (Pubitemid 28303329)
10. Bakhrat, A., Eltzov, E., Finkelstein, Y., Marks, R.S., Raveh, D., 2011. UV and arsenate toxicity: a specific and sensitive yeast bioluminescence assay. Cell Biol. Toxicol. 27, 227-236.
11. Balaguer, P., Francois, F., Comunale, F., Fenet, H., Boussioux, A.M., Pons, M., Nicolas, J.C., Casellas, C., 1999. Reporter cell lines to study the estrogenic effects of xenoestrogens. Sci. Total Environ. 233, 47-56. (Pubitemid 29389755)
12. Balsiger, H.A., de la Torre, R., Lee, W.Y., Cox, M.B., 2010. A four-hour yeast bioassay for the direct measure of estrogenic activity in wastewater without sample extraction, concentration, or sterilization. Sci. Total Environ. 408, 1422-1429.
13. Baumstark-Khan, C., Cioara, K., Rettberg, P., Horneck, G., 2005. Determination of geno-and cytotoxicity of groundwater and sediments using the recombinant SWITCH test. J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng. 40, 245-263. (Pubitemid 40180035)
14. Bechor, O., Smulski, D.R., Van Dyk, T.K., LaRossa, R.A., Belkin, S., 2002. Recombinant microorganisms as environmental biosensors: pollutants detection by Escherichia coli bearing fabA':: lux fusions. J. Biotechnol. 94, 125-132. (Pubitemid 34127672)
15. Beek, I.C., Bruhn, R., Gandrass, J., 2006. Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen. Chemosphere 63, 1870-1878.
16. Beggah, S., Vogne, C., Zenaro, E., van der Meer, J.R., 2008. Mutant HbpR transcription activator isolation for 2-chlorobiphenyl via green fluorescent protein-based flow cytometry and cell sorting. Microb. Biotechnol. 1, 68-78.
17. Behzadian, F., Barjeste, H., Hosseinkhani, S., Zarei, A.R., 2011. Construction and characterization of Escherichia coli whole-cell biosensors for toluene and related compounds. Curr. Microbiol. 62, 690-696.
18. Belkin, S., Smulski, D.R., Vollmer, A.C., Van Dyk, T.K., LaRossa, R.A., 1996. Oxidative stress detection with Escherichia coli harboring a katG'::lux fusion. Appl. Environ. Microbiol. 62, 2252-2256. (Pubitemid 26231185)
19. Bell, G., Hey, T., Szalay, A., 2009. Beyond the data deluge. Science 323, 1297-1298.
20. Bergamasco, A.M.D., Eldridge, M., Sanseverino, J., Sodre, F.F., Montagner, C.C., Pescara, I.C., Jardim, W.F., Umbuzeiro, G.D., 2011. Bioluminescent yeast estrogen assay (BLYES) as a sensitive tool to monitor surface and drinking water for estrogenicity. J. Environ. Monit. 13, 3288-3293.
21. Bhattacharyya, J., Read, D., Amos, S., Dooley, S., Killham, K., Paton, G.I., 2005. Biosensor-based diagnostics of contaminated groundwater: assessment and remediation strategy. Environ. Pollut. 134, 485-492.
22. Bolan, N.S., Adriano, D.C., Mahimairaja, S., 2004. Distribution and bioavailability of trace elements in livestock and poultry manure by-products. Crit. Rev. Environ. Sci. Technol. 34, 291-338. (Pubitemid 38669581)
23. Bondarenko, O., Rolova, T., Kahru, A., Ivask, A., 2008. Bioavailability of Cd, Zn and Hg in soil to nine recombinant luminescent metal sensor bacteria. Sensors 8, 6899-6923.
24. Boyanapalli, R., Bullerjahn, G.S., Pohl, C., Croot, P.L., Boyd, P.W., McKay, R.M.L., 2007. Luminescent whole-cell cyanobacterial bioreporter for measuring Fe availability in diverse marine environments. Appl. Environ. Microbiol. 73, 1019-1024. (Pubitemid 46233525)
25. Brandt, K.K., Holm, P.E., Nybroe, O., 2006. Bioavailability and toxicity of soil particle-associated copper as determined by two bioluminescent Pseudomonas fluorescens biosensor strains. Environ. Toxicol. Chem. 25, 1738-1741. (Pubitemid 44669842)
26. Brandt, K.K., Holm, P.E., Nybroe, O., 2008. Evidence for bioavailable copper-dissolved organic matter complexes and transiently increased copper bioavailability in manure-amended soils as determined by bioluminescent bacterial biosensors. Environ. Sci. Technol. 42, 3102-3108. (Pubitemid 351536961)
27. Breitbarth, E., Gelting, J., Walve, J., Hoffmann, L.J., Turner, D.R., Hassellov, M., Ingri, J., 2009. Dissolved iron (II) in the Baltic Sea surface water and implications for cyanobacterial bloom development. Biogeosciences 6, 2397-2420.
28. Bullerjahn, G.S., Boyanapalli, R., Rozmarynowycz, M.J., McKay, R.M.L., 2010. Cyanobacterial bioreporters as sensors of nutrient availability. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems II: Applications. Springer-Verlag, Berlin, Germany, pp. 165-188.
29. Bundy, J.G., Campbell, C.D., Paton, G.I., 2001. Comparison of response of six different luminescent bacterial bioassays to bioremediation of five contrasting oils. J. Environ. Monit. 3, 404-410.
30. Cargouet, M., Perdiz, D., Levi, Y., 2007. Evaluation of the estrogenic potential of river and treated waters in the Paris area (France) using in vivo and in vitro assays. Ecotox. Environ. Safe. 67, 149-156. (Pubitemid 46517650)
31. Cargouet, M., Perdiz, D., Mouatassim-Souali, A., Tamisier-Karolak, S., Levi, Y., 2004. Assessment of river contamination by estrogenic compounds in Paris area (France). Sci. Total Environ. 324, 55-66. (Pubitemid 38481865)
32. Cavenee, W.K., Dryja, T.P., Phillips, R.A., Benedict, W.F., Godbout, R., Gallie, B.L., Murphie, A.L., Strong, A.L., White, R.L., 1983. Expression of recessive allele by chromosomal mechanism in retinoblastoma. Nature 305, 779-784. (Pubitemid 13010953)
33. Chang, J.C., Taylor, P.B., Leach, F.R., 1981. Use of the Microtox assay system for environmental samples. Bull. Environ. Contam. Toxicol. 26, 150-156.
34. Close, D.M., Patterson, S.S., Ripp, S., Baek, S.J., Sanseverino, J., Sayler, G.S., 2010. Autonomous bioluminescent expression of the bacterial luciferase gene cassette (lux) in a mammalian cell line. PLoS ONE 5, e12441.
35. Close, D.M., Ripp, S., Sayler, G.S., 2009. Reporter proteins in whole-cell optical bioreporter detection systems, biosensor integrations, and biosensing applications. Sensors 9, 9147-9174.
36. Close, D.M., Xu, T., Smartt, A.E., Rogers, A., Crossley, R., Price, S., Ripp, S., Sayler, G.S., 2012. The evolution of the bacterial luciferase gene cassette (lux) as a real-time bioreporter. Sensors 12, 732-752.
37. Corbisier, P., Ji, G., Nuyts, G., Mergeay, M., Silver, S., 1993. luxAB gene fusions with the arsenic and cadmium resistance operons of Staphylococcus aureus plasmid pI258. FEMS Microbiol. Lett. 110, 231-238. (Pubitemid 23180027)
38. Corbisier, P., Thiry, E., Diels, L., 1996. Bacterial biosensors for the toxicity assessment of solid waste. Environ. Toxicol. Water Quality 11, 171-177. (Pubitemid 26334655)
39. Craney, A., Hohenauer, T., Xu, Y., Navani, N.K., Li, Y.F., Nodwell, J., 2007. A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria. Nucleic Acids Res. 35, e46.
40. Dagnino, S., Gomez, E., Picot, B., Cavailles, V., Casellas, C., Balaguer, P., Fenet, H., 2010. Estrogenic and AhR activities in dissolved phase and suspended solids from wastewater treatment plants. Sci. Total Environ. 408, 2608-2615.
41. Date, A., Pasini, P., Daunert, S., 2010. Fluorescent and bioluminescent cell-based sensors: strategies for their preservation. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems I: Reporter Cells and Devices. Springer-Verlag, Berlin, Germany, pp. 57-75.
42. Dawson, J.J.C., Godsiffe, E.J., Thompson, I.P., Ralebitso-Senior, T.K., Killham, K.S., Paton, G.I., 2007. Application of biological indicators to assess recovery of hydrocarbon impacted soils. Soil Biol. Biochem. 39, 164-177. (Pubitemid 44755388)
43. Dawson, J.J.C., Iroegbu, C.O., Maciel, H., Paton, G.I., 2008. Application of luminescent biosensors for monitoring the degradation and toxicity of BTEX compounds in soils. J. Appl. Microbiol. 104, 141-151. (Pubitemid 350265316)
44. Degryse, F., Smolders, E., Parker, D.R., 2009. Partitioning of metals (Cd, Co, Cu, Ni, Pb, Zn) in soils: concepts, methodologies, prediction and applications-A review. Eur. J. Soil Sci. 60, 590-612.
45. Diesel, E., Schreiber, M., van der Meer, J.R., 2009. Development of bacteria-based bioassays for arsenic detection in natural waters. Anal. Bioanal. Chem. 394, 687-693.
46. Dindal, A., Thompson, E., Aume, L., Billets, S., 2007. Application of site-specific calibration data using the CALUX by XDS bioassay for dioxin-like chemicals in soil and sediment samples. Environ. Sci. Technol. 41, 8376-8382. (Pubitemid 350276444)
47. Diplock, E.E., Alhadrami, H.A., Paton, G.I., 2010. Application of microbial bioreporters in environmental microbiology and bioremediation. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems II. Springer-Verlag, Berlin, Germany, pp. 189-209.
48. Diplock, E.E., Mardlin, D.P., Killham, K.S., Paton, G.I., 2009. Predicting bioremediation of hydrocarbons: laboratory to field scale. Environ. Pollut. 157, 1831-1840.
49. Durham, K.A., Porta, D., Twiss, M.R., McKay, R.M.L., Bullerjahn, G.S., 2002. Construction and initial characterization of a luminescent Synechococcus sp. PCC 7942 Fe-dependent bioreporter. FEMS Microbiol. Lett. 209, 215-221. (Pubitemid 34465595)
50. Elad, T., Benovich, E., Magrisso, S., Belkin, S., 2008. Toxicant identification by a luminescent bacterial bioreporter panel: application of pattern classification algorithms. Environ. Sci. Technol. 42, 8486-8491.
51. Eldridge, M.L., Sanseverino, J., Layton, A.C., Easter, J.P., Schultz, T.W., Sayler, G.S., 2007. Saccharomyces cerevisiae BLYAS, a new bioluminescent bioreporter for detection of androgenic compounds. Appl. Environ. Microbiol. 73, 6012-6018. (Pubitemid 47548007)
52. Eltzov, E., Marks, R.S., 2011. Whole-cell aquatic biosensors. Anal. Bioanal. Chem. 400, 895-913.
53. Eltzov, E., Marks, R.S., Voost, S., Wullings, B.A., Heringa, M.B., 2009. Flow-through real time bacterial biosensor for toxic compounds in water. Sens. Actuator B-Chem. 142, 11-18.
54. Everhart, J.L., McNear, D., Peltier, E., van der Lelie, D., Chaney, R.L., Sparks, D.L., 2006. Assessing nickel bioavailability in smelter-contaminated soils. Sci. Total Environ. 367, 732-744. (Pubitemid 44093686)
55. Feliciano, J., Xu, S.F., Guan, X.Y., Lehmler, H.J., Bachas, L.G., Daunert, S., 2006. ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls. Anal. Bioanal. Chem. 385, 807-813. (Pubitemid 350153355)
56. Fernandez, M.P., Campbell, P.M., Ikonomou, M.G., Devlin, R.H., 2007. Assessment of environmental estrogens and the intersex/sex reversal capacity for chinook salmon (Oncorhynchus tshawytscha) in primary and final municipal wastewater effluents. Environ. Int. 33, 391-396.
57. Fleming, J.T., 2010. Electronic interfacing with living cells. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems I: Reporter Cells and Devices. Springer-Verlag, Berlin, Germany, pp. 155-178.
58. Flynn, H.C., McMahon, V., Diaz, G.C., Demergasso, C.S., Corbisier, P., Meharg, A.A., Paton, G.I., 2002. Assessment of bioavailable arsenic and copper in soils and sediments from the Antofagasta region of northern Chile. Sci. Total Environ. 286, 51-59. (Pubitemid 34157213)
59. Flynn, H.C., Meharg, A.A., Bowyer, P.K., Paton, G.I., 2003. Antimony bioavailability in mine soils. Environ. Pollut. 124, 93-100. (Pubitemid 36390306)
60. Gaido, K.W., Leonard, L.S., Lovell, S., Gould, J.C., Babai, D., Portier, C.J., McDonnell, D.P., 1997. Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143, 205-212. (Pubitemid 27130624)
61. Ghim, C.M., Lee, S.K., Takayama, S., Mitchell, R.J., 2010. The art of reporter proteins in science: past, present and future applications. BMB Reports 43, 451-460.
62. Giller, K.E., Witter, E., McGrath, S.P., 2009. Heavy metals and soil microbes. Soil Biol. Biochem. 41, 2031-2037.
63. Grund, S., Higley, E., Schonenberger, R., Suter, M.J.F., Giesy, J.P., Braunbeck, T., Hecker, M., Hollert, H., 2011. The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis. Environ. Sci. Pollut. Res. 18, 446-460.
64. Gu, M.B., Kim, B.C., Cho, J., Hansen, P.D., 2001. The continuous monitoring of field water samples with a novel multi-channel two-stage mini-bioreactor system. Environmental Monitoring and Assessment 70, 71-81. (Pubitemid 32684589)
65. Gu, M.B., Min, J., Kim, E.J., 2002. Toxicity monitoring and classification of endocrine disrupting chemicals (EDCs) using recombinant bioluminescent bacteria. Chemosphere 46, 289-294. (Pubitemid 34072372)
66. Gupta, R.K., Patterson, S.S., Ripp, S., Sayler, G.S., 2003. Expression of the Photorhabdus luminescens lux genes (luxA, BCD, and E) in Saccharomyces cerevisiae. FEMS Yeast Res. 4, 305-313. (Pubitemid 37494729)
67. Hakkila, K., Green, T., Leskinen, P., Ivask, A., Marks, R., Virta, M., 2004. Detection of bioavailable heavy metals in EILATox-Oregon samples using whole-cell luminescent bacterial sensors in suspension or immobilized onto fibre-optic tips. J. Appl. Toxicol. 24, 333-342. (Pubitemid 39409914)
68. Hakkila, K., Maksimow, M., Karp, M., Virta, M., 2002. Reporter genes lucFF, luxCDABE, gfp, and dsred have different characteristics in whole-cell bacterial sensors. Anal. Biochem. 301, 235-242. (Pubitemid 34158188)
69. Harms, H., Wells, M.C., van der Meer, J.R., 2006. Whole-cell living biosensors-are they ready for environmental application? Appl. Microbiol. Biotechnol. 70, 273-280. (Pubitemid 43345151)
70. Hassler, C.S., Havens, S.M., Bullerjahn, G.S., McKay, R.M.L., Twiss, M.R., 2009. An evaluation of iron bioavailability and speciation in western Lake Superior with the use of combined physical, chemical, and biological assessment. Limnol. Oceanogr. 54, 987-1001.
71. Hassler, C.S., Twiss, M.R., McKay, R.M.L., Bullerjahn, G.S., 2006. Optimization of iron-dependent cyanobacterial (Synechococcus Cyanophyceae) bioreporters to measure iron bioavailability. J. Phycol. 42, 324-335.
72. Hay, A.G., Rice, J.F., Applegate, B.M., Bright, N.G., Sayler, G.S., 2000. A bioluminescent whole-cell reporter for detection of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenol in soil. Appl. Environ. Microbiol. 66, 4589-4594.
73. He, Y.H., Wiseman, S.B., Hecker, M., Zhang, X.W., Wang, N., Perez, L.A., Jones, P.D., El-Din, M.G., Martin, J.W., Giesy, J.P., 2011. Effect of ozonation on the estrogenicity and androgenicity of oil sands process-affected water. Environ. Sci. Technol. 45, 6268-6274.
74. Heitzer, A., Webb, O.F., Thonnard, J.E., Sayler, G.S., 1992. Specific and quantitative assessment of naphthalene and salicylate bioavailability by using a bioluminescent catabolic reporter bacterium. Appl. Environ. Microbiol. 58, 1839-1846.
75. Hernandez-Raquet, G., Soef, A., Delgenes, N., Balaguer, P., 2007. Removal of the endocrine disrupter nonylphenol and its estrogenic activity in sludge treatment processes. Water Res. 41, 2643-2651. (Pubitemid 46770819)
76. Hever, N., Belkin, S., 2006. A dual-color bacterial reporter strain for the detection of toxic and genotoxic effects. Eng. Life Sci. 6, 319-323. (Pubitemid 44069855)
77. Hey, T., Tansley, S., Tolle, K., 2009. The Fourth Paradigm: Data-intensive Scientific Discovery. Microsoft Research, Redmond, Washington.
78. Hilscherova, K., Dusek, L., Sidlova, T., Jalova, V., Cupr, P., Giesy, J.P., Nehyba, S., Jarkovsky, J., Klanova, J., Holoubek, I., 2010. Seasonally and regionally determined indication potential of bioassays in contaminated river sediments. Environ. Toxicol. Chem. 29, 522-534.
79. Hollis, R.P., Lagido, C., Pettitt, J., Porter, A.J.R., Killham, K., Paton, G.I., Glover, L.A., 2001. Toxicity of the bacterial luciferase substrate, n-decyl aldehyde, to Saccharomyces cerevisiae and Caenorhabditis elegans. FEBS Lett. 506, 140-142. (Pubitemid 32925216)
80. Houtman, C.J., Booij, P., Jover, E., del Rio, D.P., Swart, K., van Velzen, M., Vreuls, R., Legler, J., Brouwer, A., Lamoree, M.H., 2006. Estrogenic and dioxinlike compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses. Chemosphere 65, 2244-2252. (Pubitemid 44751833)
81. Hynninen, A., Virta, M., 2010. Whole-cell bioreporters for the detection of bioavailable metals. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems II: Applications. Springer-Verlag, Berlin, Germany, pp. 31-63.
82. Ivask, A., Dubourguier, H.C., Pollumaa, L., Kahru, A., 2011. Bioavailability of Cd in 110 polluted topsoils to recombinant bioluminescent sensor bacteria: effect of soil particulate matter. J. Soils Sediments 11, 231-237.
83. Ivask, A., Francois, M., Kahru, A., Dubourguier, H.C., Virta, M., Douay, F., 2004. Recombinant luminescent bacterial sensors for the measurement of bioavailability of cadmium and lead in soils polluted by metal smelters. Chemosphere 55, 147-156. (Pubitemid 38175270)
84. Ivask, A., Green, T., Polyak, B., Mor, A., Kahru, A., Virta, M., Marks, R., 2007. Fibreoptic bacterial biosensors and their application for the analysis of bioavailable Hg and As in soils and sediments from Aznalcollar mining area in Spain. Biosens. Bioelectron. 22, 1396-1402. (Pubitemid 46157006)
85. Ivask, A., Hakkila, K., Virta, M., 2001. Detection of organomercurials with sensor bacteria. Anal. Chem. 73, 5168-5171. (Pubitemid 33032232)
86. Ivask, A., Rolova, T., Kahru, A., 2009. A suite of recombinant luminescent bacterial strains for the quantification of bioavailable heavy metals and toxicity testing. BMC Biotechnol. 9, 41.
87. Ivask, A., Virta, M., Kahru, A., 2002. Construction and use of specific luminescent recombinant bacterial sensors for the assessment of bioavailable fraction of cadmium, zinc, mercury and chromium in the soil. Soil Biol. Biochem. 34, 1439-1447. (Pubitemid 35180909)
88. Jain, V.K., Magrath, I.T., 1991. A chemiluminescent assay for quantitation of beta-galactosidase in the femtogram range-application to quantitation of betagalactosidase in lacZ-transfected cells. Anal. Biochem. 199, 119-124.
89. Jaspers, M.C.M., Suske, W.A., Schmid, A., Goslings, D.A.M., Kohler, H.P.E., van der Meer, J.R., 2000. HbpR, a new member of the XylR/DmpR subclass within the NtrC family of bacterial transcriptional activators, regulates expression of 2-hydroxybiphenyl metabolism in Pseudomonas azelaica HBP1. J. Bacteriol. 182, 405-417. (Pubitemid 30030125)
90. Jeffries, M.K.S., Conoan, N.H., Cox, M.B., Sangster, J.L., Balsiger, H.A., Bridges, A.A., Cowman, T., Knight, L.A., Bartelt-Hunt, S.L., Kolok, A.S., 2011. The anti-estrogenic activity of sediments from agriculturally intense watersheds: assessment using in vivo and in vitro assays. Aquat. Toxicol. 105, 189-198.
91. Jouanneau, S., Durand, M.J., Courcoux, P., Blusseau, T., Thouand, G., 2011. Improvement of the identification of four heavy metals in environmental samples by using predictive decision tree models coupled with a set of five bioluminescent bacteria. Environ. Sci. Technol. 45, 2925-2931.
92. Keiter, S., Grund, S., van Bavel, B., Hagberg, J., Engwall, M., Kammann, U., Klempt, M., Manz, W., Olsman, H., Braunbeck, T., Hollert, H., 2008. Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river. Anal. Bioanal. Chem. 390, 2009-2019. (Pubitemid 351659903)
93. Kelly, C.J., Lajoie, C.A., Layton, A.C., Sayler, G.S., 1999. Bioluminescent reporter bacterium for toxicity monitoring in biological wastewater treatment systems. Water Environ. Res. 71, 31-35. (Pubitemid 29085246)
94. Kelly, C.J., Tumsaroj, N., Lajoie, C.A., 2004. Assessing wastewater metal toxicity with bacterial bioluminescence in a bench-scale wastewater treatment system. Water Res. 38, 423-431. (Pubitemid 38367705)
95. Kelsey, J.W., Kottler, B.D., Alexander, M., 1997. Selective chemical extractants to predict bioavailability of soil-aged organic chemicals. Environ. Sci. Technol. 31, 214-217.
96. King, J.M.H., Digrazia, P.M., Applegate, B., Burlage, R., Sanseverino, J., Dunbar, P., Larimer, F., Sayler, G.S., 1990. Rapid, sensitive bioluminescent reporter technology for naphthalene exposure and biodegradation. Science 249, 778-781.
97. Knecht, L.D., Pasini, P., Daunert, S., 2011. Bacterial spores as platforms for bioanalytical and biomedical applications. Anal. Bioanal. Chem. 400, 977-989.
98. Kuncova, G., Pazlarova, J., Hlavata, A., Ripp, S., Sayler, G.S., 2011. Bioluminescent bioreporter Pseudomonas putida TVA8 as a detector of water pollution, Operational conditions and selectivity of free cells sensor. Ecol. Indic. 11, 882-887.
99. Lajoie, C.A., Lin, S.C., Kelly, C.J., 2003. Comparison of bacterial bioluminescence with activated sludge oxygen uptake rates during zinc toxic shock loads in a wastewater treatment system. J. Environ. Eng.-ASCE 129, 879-883. (Pubitemid 37156336)
100. Lampinen, J., Koivisto, L., Wahlsten, M., Mantsala, P., Karp, M., 1992. Expression of luciferase genes from different origins in Bacillus subtilis. Mol. Gen. Genet. 232, 498-504.
101. Lankinen, P., Khknen, M., Rajasrkk, J., Virta, M., Hatakka, A., 2011. The effect of nickel contamination on the growth of litter-decomposing fungi, extracellular enzyme activities and toxicity in soil. Boreal Environ. Res. 16, 229-239.
102. Lappalainen, J.O., Karp, M.T., Nurmi, J., Juvonen, R., Virta, M.P.J., 2000. Comparison of the total mercury content in sediment samples with a mercury sensor bacteria test and Vibrio fischeri toxicity test. Environ. Toxicol. 15, 443-448.
103. Larose, C., Dommergue, A., Marusczak, N., Coves, J., Ferrari, C.P., Schneider, D., 2011. Bioavailable mercury cycling in polar snowpacks. Environ. Sci. Technol. 45, 2150-2156.
104. Layton, A.C., Muccini, M., Ghosh, M.M., Sayler, G.S., 1998. Construction of a bioluminescent reporter strain to detect polychlorinated biphenyls. Appl. Environ. Microbiol. 64, 5023-5026. (Pubitemid 28557878)
105. Leedjarv, A., Ivask, A., Virta, M., Kahru, A., 2006. Analysis of bioavailable phenols from natural samples by recombinant luminescent bacterial sensors. Chemosphere 64, 1910-1919. (Pubitemid 44092945)
106. Leskinen, P., Hilscherova, K., Sidlova, T., Kiviranta, H., Pessala, P., Salo, S., Verta, M., Virta, M., 2008. Detecting AhR ligands in sediments using bioluminescent reporter yeast. Biosens. Bioelectron. 23, 1850-1855.
107. Leskinen, P., Michelini, E., Picard, D., Karp, M., Virta, M., 2005. Bioluminescent yeast assays for detecting estrogenic and androgenic activity in different matrices. Chemosphere 61, 259-266.
108. Leusch, F.D.L., De Jager, C., Levi, Y., Lim, R., Puijker, L., Sacher, F., Tremblay, L.A., Wilson, V.S., Chapman, H.F., 2010. Comparison of five in vitro bioassays to measure estrogenic activity in environmental waters. Environ. Sci. Technol. 44, 3853-3860.
109. Liao, V.H.C., Chien, M.T., Tseng, Y.Y., Ou, K.L., 2006. Assessment of heavy metal bioavailability in contaminated sediments and soils using green fluorescent protein-based bacterial biosensors. Environ. Pollut. 142, 17-23.
110. Liu, Y.Q., Lu, X.B., 2011. Establishing a assay for detection of nonylphenol estrogenic effects. Appl. Mech. Mater. 71, 3003-3006.
111. Louiz, I., Kinani, S., Gouze, M.E., Ben-Attia, M., Menif, D., Bouchonnet, S., Porcher, J.M., Ben-Hassine, O.K., Ait-Aissa, S., 2008. Monitoring of dioxin-like, estrogenic and anti-androgenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cell-based bioassays: Contribution of low concentrations of polynuclear aromatic hydrocarbons (PAHs). Sci. Total Environ. 402, 318-329.
112. Machala, M., Vondracek, J., Blaha, L., Ciganek, M., Nea, J., 2001. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 497, 49-62. (Pubitemid 32781806)
113. Maderova, L., Watson, M., Paton, G.I., 2011. Bioavailability and toxicity of copper in soils: Integrating chemical approaches with responses of microbial biosensors. Soil Biol. Biochem. 43, 1162-1168.
114. Magrisso, S., Belkin, S., Erel, Y., 2009. Lead bioavailability in soil and soil components. Water Air Soil Pollut. 202, 315-323.
115. McKay, R.M.L., Porta, D., Bullerjahn, G.S., Al-Rshaidat, M.M.D., Klimowicz, J.A., Sterner, R.W., Smutka, T.M., Brown, E.T., Sherrell, R.M., 2005. Bioavailable iron in oligotrophic Lake Superior assessed using biological reporters. J. Plankton Res. 27, 1033-1044. (Pubitemid 41816521)
116. Meighen, E.A., 1994. Genetics of bacterial bioluminescence. Annu. Rev. Genet. 28, 117-139.
117. Metzger, D., White, J., Chambon, P., 1988. The human oestrogen receptor functions in yeast. Nature 334, 31-36.
118. Murk, A.J., Legler, J., Denison, M.S., Giesy, J.P., vandeGuchte, C., Brouwer, A., 1996. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam. Appl. Toxicol. 33, 149-160.
119. Nakada, N., Nyunoya, H., Nakamura, M., Hara, A., Iguchi, T., Takada, H., 2004. Identification of estrogenic compounds in wastewater effluent. Environ. Toxicol. Chem. 23, 2807-2815. (Pubitemid 39603322)
120. Nazarenko, D.A., Dertinger, S.D., Gasiewicz, T.A., 2001. Enhanced detection of betagalactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates. Biotechniques 30, 776-781. (Pubitemid 32319823)
121. Nelson, J., Bishay, F., van Roodselaar, A., Ikonomou, M., Law, F.C.P., 2007. The use of in vitro bioassays to quantify endocrine disrupting chemicals in municipal wastewater treatment plant effluents. Sci. Total Environ. 374, 80-90. (Pubitemid 46227558)
122. Nies, D.H., 1999. Microbial heavy-metal resistance. Appl. Microbiol. Biotechnol. 51, 730-750. (Pubitemid 29304744)
123. Nissen, S., Alexander, B.D., Dawood, I., Tillotson, M., Wells, R.P.K., Macphee, D.E., Killham, K., 2009. Remediation of a chlorinated aromatic hydrocarbon in water by photoelectrocatalysis. Environ. Pollut. 157, 72-76.
124. Nordstrom, D.K., 2002. Public health-Worldwide occurrences of arsenic in ground water. Science 296, 2143-2145.
125. Norman, A., Hansen, L.H., Sorensen, S.J., 2005. Construction of a ColD cda promoter-based SOS-green fluorescent protein whole-cell biosensor with higher sensitivity toward genotoxic compounds than constructs based on recA, umuDC, or sul4 promoters. Appl. Environ. Microbiol. 71, 2338-2346. (Pubitemid 40646975)
126. Paton, G.I., Reid, B.J., Sempled, K.T., 2009. Application of a luminescence-based biosensor for assessing naphthalene biodegradation in soils from a manufactured gas plant. Environ. Pollut. 157, 1643-1648.
127. Paton, G.I., Viventsova Ruth, E., Kumpene, J., Wilson, M.J., Weitz, H.J., Dawson, J.J.C., 2006a. An ecotoxicity assessment of contaminated forest soils from the Kola Peninsula. Sci. Total Environ. 355, 106-117. (Pubitemid 43143242)
128. Paton, G.T., Cheewasedtham, W., Marr, I.L., Dawson, J.J.C., 2006b. Degradation and toxicity of phenyltin compounds in soil. Environ. Pollut. 144, 746-751. (Pubitemid 44344909)
129. Peca, L., Kos, P.B., Mate, Z., Farsang, A., Vass, I., 2008. Construction of bioluminescent cyanobacterial reporter strains for detection of nickel, cobalt and zinc. FEMS Microbiol. Lett. 289, 258-264.
130. Peng, Z.X., Yan, Y.L., Xu, Y.Q., Takeo, M., Yu, H.Y., Zhao, Z.L., Zhan, Y.H., Zhang, W., Lin, M., Chen, M., 2010. Improvement of an E. coli bioreporter for monitoring trace amounts of phenol by deletion of the inducible sigma(54)-dependent promoter. Biotechnol. Lett. 32, 1265-1270.
131. Porta, D., Bullerjahn, G.S., Twiss, M.R., Wilhelm, S.W., Poorvin, L., McKay, R.M.L., 2005. Determination of bioavailable Fe in Lake Erie using a luminescent cyanobacterial bioreporter. J. Gt. Lakes Res. 31, 180-194.
132. Quillardet, P., Huisman, O., Dari, R., Hofnung, M., 1982. SOS Chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity. Proc. Natl. Acad. Sci. U. S. A. 79, 5971-5975. (Pubitemid 13249960)
133. Radhika, V., Proikas-Cezanne, T., Jayaraman, M., Onesime, D., Ha, J.H., Dhanasekaran, D.N., 2007. Chemical sensing of DNT by engineered olfactory yeast strain. Nat. Chem. Biol. 3, 325-330. (Pubitemid 46789269)
134. Rattray, E.A.S., Prosser, J.I., Killham, K., Glover, L.A., 1990. Luminescence-based nonextractive technique for in situ detection of Escherichia coli in soil. Appl. Environ. Microbiol. 56, 3368-3374. (Pubitemid 20380711)
135. Ren, S., Frymier, P.D., 2003. The use of a genetically engineered Pseudomonas species (Shk1) as a bioluminescent reporter for heavy metal toxicity screening in wastewater treatment plant influent. Water Environ. Res. 75, 21-29. (Pubitemid 40674470)
136. Ripp, S., Layton, A.C., Sayler, G.S., 2011. The microbe as a reporter: microbial bioreporter sensing technologies for chemical and biological detection. In: K. Sen, Ashbolt, N.J. (Eds.), Environmental Microbiology: Current Technology and Water Applications. Caister Academic Press, Norfolk, UK, pp. 281-308.
137. Ripp, S., Nivens, D.E., Ahn, Y., Werner, C., Jarrell, J., Easter, J.P., Cox, C.D., Burlage, R.S., Sayler, G.S., 2000. Controlled field release of a bioluminescent genetically engineered microorganism for bioremediation process monitoring and control. Environ. Sci. Technol. 34, 846-853. (Pubitemid 30129829)
138. Robbens, J., Dardenne, F., Devriese, L., De Coen, W., Blust, R., 2010. Escherichia coli as a bioreporter in ecotoxicology. Appl. Microbiol. Biotechnol. 88, 1007-1025.
139. Ron, E.Z., Rishpon, J., 2010. Electrochemical cell-based sensors. In: Belkin, S., Gu, M.B. (Eds.), Whole Cell Sensing Systems I: Reporter Cells and Devices. Spring-Verlag, Berlin, Germany, pp. 77-84.
140. Routledge, E.J., Sumpter, J.P., 1996. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ. Toxicol. Chem. 15, 241-248. (Pubitemid 26069072)
141. Rowland, B., Purkayastha, A., Monserrat, C., Casart, Y., Takiff, H., McDonough, K.A., 1999. Fluorescence-based detection of lacZ reporter gene expression in intact and viable bacteria including Mycobacterium species. FEMS Microbiol. Lett. 179, 317-325. (Pubitemid 29460694)
142. Salste, L., Leskinen, P., Virta, M., Kronberg, L., 2007. Determination of estrogens and estrogenic activity in wastewater effluent by chemical analysis and the bioluminescent yeast assay. Sci. Total Environ. 378, 343-351. (Pubitemid 46654155)
143. Sanseverino, J., Gupta, R.K., Layton, A.C., Patterson, S.S., Ripp, S.A., Saidak, L., Simpson, M.L., Schultz, T.W., Sayler, G.S., 2005. Use of Saccharomyces cerevisiae BLYES expressing bacterial bioluminescence for rapid, sensitive detection of estrogenic compounds. Appl. Environ. Microbiol. 71, 4455-4460. (Pubitemid 41129499)
144. Selifonova, O.V., Eaton, R.W., 1996. Use of an ipb-lux fusion to study regulation of the isopropylbenzene catabolism operon of Pseudomonas putida RE204 and to detect hydrophobic pollutants in the environment. Appl. Environ. Microbiol. 62, 778-783. (Pubitemid 26071446)
145. Semple, K.T., Morriss, A.W.J., Paton, G.I., 2003. Bioavailability of hydrophobic organic contaminants in soils: fundamental concepts and techniques for analysis. Eur. J. Soil Sci. 54, 809-818. (Pubitemid 37502505)
146. Shaner, N.C., Steinbach, P.A., Tsien, R.Y., 2005. A guide to choosing fluorescent proteins. Nat. Methods 2, 905-909. (Pubitemid 43108726)
147. Shaw, J.J., Kado, C.I., 1986. Development of a Vibrio bioluminescence gene set to monitor phytopathogenic bacteria during the ongoing disease process in a nondisruptive manner. Nat. Biotechnol. 4, 560-564.
148. Shibasaki, S., Ueda, M., Ye, K., Shimizu, K., Kamasawa, N., Osumi, M., Tanaka, A., 2001. Creation of cell surface-engineered yeast that display different fluorescent proteins in response to the glucose concentration. Appl. Microbiol. Biotechnol. 57, 528-533. (Pubitemid 33044131)
149. Shin, H.J., Park, H.H., Lim, W.K., 2005. Freeze-dried recombinant bacteria for on-site detection of phenolic compounds by color change. J. Biotechnol. 119, 36-43. (Pubitemid 41112615)
150. Shingler, V., Moore, T., 1994. Sensing of aromatic compounds by the DmpR transcriptional activator of phenol-catabolizing Pseudomonas sp. strain CF600. J. Bacteriol. 176, 1555-1560. (Pubitemid 24100203)
151. Shingleton, J.T., Applegate, B.M., Nagel, A.C., Bienkowski, P.R., Sayler, G.S., 1998. Induction of the tod operon by trichloroethylene in Pseudomonas putida TVA8. Appl. Environ. Microbiol. 64, 5049-5052. (Pubitemid 28557885)
152. Sidlova, T., Novak, J., Janosek, J., Andel, P., Giesy, J.P., Hilscherova, K., 2009. Dioxinlike and endocrine disruptive activity of traffic-contaminated soil samples. Arch. Environ. Contam. Toxicol. 57, 639-650.
153. Song, Y.Z., Li, G.H., Thornton, S.F., Thompson, I.P., Banwart, S.A., Lerner, D.N., Huang, W.E., 2009. Optimization of bacterial whole cell bioreporters for toxicity assay of environmental samples. Environ. Sci. Technol. 43, 7931-7938.
154. Sousa, S., Duffy, C., Weitz, H., Glover, L.A., Bar, E., 1998. Use of a lux-modified bacterial, biosensor to identify constraints to bioremediation of BTEX-contaminated sites. Environ. Toxicol. Chem. 17, 1039-1045. (Pubitemid 28232831)
155. Sticher, P., Jaspers, M.C.M., Stemmler, K., Harms, H., Zehnder, A.J.B., van der Meer, J.R., 1997. Development and characterization of a whole-cell bioluminescent sensor for bioavailable middle-chain alkanes in contaminated groundwater samples. Appl. Environ. Microbiol. 63, 4053-4060. (Pubitemid 27411370)
156. Stiner, L., Halverson, L.J., 2002. Development and characterization of a green fluorescent protein-based bacterial biosensor for bioavailable toluene and related compounds. Appl. Environ. Microbiol. 68, 1962-1971. (Pubitemid 34280008)
157. Stocker, J., Balluch, D., Gsell, M., Harms, H., Feliciano, J., Daunert, S., Malik, K.A., van der Meer, J.R., 2003. Development of a set of simple bacterial biosensors for quantitative and rapid measurements of arsenite and arsenate in potable water. Environ. Sci. Technol. 37, 4743-4750. (Pubitemid 37266395)
158. Struss, A.K., Pasini, P., Daunert, S., 2010. Biosensing systems based on genetically engineered whole cells. In: Zourob, M. (Ed.), Recognition Receptors in Biosensors. Springer, New York, pp. 565-598.
159. Suzuki, G., Someya, M., Takahashi, S., Tanabe, S., Sakai, S., Takigami, H., 2010. Dioxinlike activity in Japanese indoor dusts evaluated by means of in vitro bioassay and instrumental analysis: brominated dibenzofurans are an important contributor. Environ. Sci. Technol. 44, 8330-8336.
160. Tauriainen, S., Karp, M., Chang, W., Virta, M., 1998. Luminescent bacterial sensor for cadmium and lead. Biosens. Bioelectron. 13, 931-938. (Pubitemid 28506003)
161. Tauriainen, S., Virta, M., Chang, W., Karp, M., 1999. Measurement of firefly luciferase reporter gene activity from cells and lysates using Escherichia coli arsenite and mercury sensors. Anal. Biochem. 272, 191-198. (Pubitemid 29364982)
162. Tecon, R., Beggah, S., Czechowska, K., Sentchilo, V., Chronopoulou, P.M., McGenity, T.J., van der Meer, J.R., 2010. Development of a multistrain bacterial bioreporter platform for the monitoring of hydrocarbon contaminants in marine environments. Environ. Sci. Technol. 44, 1049-1055.
163. Tecon, R., Binggeli, O., van der Meer, J.R., 2009. Double-tagged fluorescent bacterial bioreporter for the study of polycyclic aromatic hydrocarbon diffusion and bioavailability. Environ. Microbiol. 11, 2271-2283.
164. Tecon, R., van der Meer, J.R., 2008. Bacterial biosensors for measuring availability of environmental pollutants. Sensors 8, 4062-4080.
165. Tecon, R., Wells, M., van der Meer, J.R., 2006. A new green fluorescent protein-based bacterial biosensor for analysing phenanthrene fluxes. Environ. Microbiol. 8, 697-708. (Pubitemid 43363326)
166. Thorpe, K.L., Gross-Sorokin, M., Johnson, I., Brighty, G., Tyler, C.R., 2006. An assessment of the model of concentration addition for predicting the estrogenic activity of chemical mixtures in wastewater treatment works effluents. Environ. Health Perspect. 114, 90-97.
167. Tibazarwa, C., Corbisier, P., Mench, M., Bossus, A., Solda, P., Mergeay, M., Wyns, L., van der Lelie, D., 2001. A microbial biosensor to predict bioavailable nickel in soil and its transfer to plants. Environ. Pollut. 113, 19-26.
168. Tiensing, T., Strachan, N., Paton, G.I., 2002. Evaluation of interactive toxicity of chlorophenols in water and soil using lux-marked biosensors. J. Environ. Monit. 4, 482-489. (Pubitemid 34864575)
169. Toba, F.A., Hay, A.G., 2005. A simple solid phase assay for the detection of 2,4-D in soil. J. Microbiol. Methods 62, 135-143. (Pubitemid 40991434)
170. Tom-Petersen, A., Hosbond, C., Nybroe, O., 2001. Identification of copper-induced genes in Pseudomonas fluorescens and use of a reporter strain to monitor bioavailable copper in soil. FEMS Microbiol. Ecol. 38, 59-67. (Pubitemid 34033721)
171. Trang, P.T.K., Berg, M., Viet, P.H., Van Mui, N., van der Meer, J.R., 2005. Bacterial bioassay for rapid and accurate analysis of arsenic in highly variable groundwater samples. Environ. Sci. Technol. 39, 7625-7630. (Pubitemid 41407495)
172. Tropel, D., van der Meer, J.R., 2004. Bacterial transcriptional regulators for degradation pathways of aromatic compounds. Microbiol. Mol. Biol. Rev. 68, 474-500. (Pubitemid 39238279)
173. Turpeinen, R., Salminen, J., Kairesalo, T., 2000. Mobility and bioavailability of lead in contaminated boreal forest soil. Environ. Sci. Technol. 34, 5152-5156.
174. Turpeinen, R., Virta, M., Haggblom, M.M., 2003. Analysis of arsenic bioavailability in contaminated soils. Environ. Toxicol. Chem. 22, 1-6. (Pubitemid 35471314)
175. van der Meer, J.R., Belkin, S., 2010. Where microbiology meets microengineering: design and applications of reporter bacteria. Nat. Rev. Microbiol. 8, 511-522.
176. Van Dyk, T.K., Majarian, W.R., Konstantinov, K.B., Young, R.M., Dhurjati, P.S., Larossa, R.A., 1994. Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions. Appl. Environ. Microbiol. 60, 1414-1420. (Pubitemid 24144794)
177. Virta, M., Lampinen, J., Karp, M., 1995. A luminescence-based mercury biosensor. Anal. Chem. 67, 667-669.
178. Vollmer, A.C., Belkin, S., Smulski, D.R., VanDyk, T.K., LaRossa, R.A., 1997. Detection of DNA damage by use of Escherichia coli carrying recA'-lux, uvrA'-lux, or alkA'-lux reporter plasmids. Appl. Environ. Microbiol. 63, 2566-2571. (Pubitemid 27292843)
179. Walmsley, R.M., Keenan, P., 2000. The eukaryote alternative: advantages of using yeasts in place of bacteria in microbial biosensor development. Biotechnol. Bioprocess Eng. 5, 387-394.
180. Wehmas, L.C., Cavallin, J.E., Durhan, E.J., Kahl, M.D., Martinovic, D., Mayasich, J., Tuominen, T., Villeneuve, D.L., Ankley, G.T., 2011. Screening complex effluents for estrogenic activity with the T47D-KBluc cell bioassay: assay optimization and comparison with in vivo responses in fish. Environ. Toxicol. Chem. 30, 439-445.
181. Weitz, H.J., Ritchie, J.M., Bailey, D.A., Horsburgh, A.M., Killham, K., Glover, L.A., 2001. Construction of a modified mini-Tn5 luxCDABE transposon for the development of bacterial biosensors for ecotoxicity testing. FEMS Microbiol. Lett. 197, 159-165. (Pubitemid 32324176)
182. Willardson, B.M., Wilkins, J.F., Rand, T.A., Schupp, J.M., Hill, K.K., Keim, P., Jackson, P.J., 1998. Development and testing of a bacterial biosensor for toluene-based environmental contaminants. Appl. Environ. Microbiol. 64, 1006-1012. (Pubitemid 28108477)
183. Wilson, V.S., Bobseine, K., Gray, L.E., 2004. Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists. Toxicol. Sci. 81, 69-77. (Pubitemid 39199865)
184. Wilson, V.S., Bobseine, K., Lambright, C.R., Gray, L.E., 2002. A novel cell line, MDAkb2, that stably expresses an androgen-and glucocorticoid- responsive reporter for the detection of hormone receptor agonists and antagonists. Toxicol. Sci. 66, 69-81. (Pubitemid 34202030)
185. Wolz, J., Engwall, M., Maletz, S., Takner, H.O., van Bavel, B., Kammann, U., Klempt, M., Weber, R., Braunbeck, T., Hollert, H., 2008. Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine-A mass balance approach using in vitro methods and chemical analysis. Environ. Sci. Pollut. Res. 15, 536-553.
186. Yagur-Kroll, S., Belkin, S., 2011. Upgrading bioluminescent bacterial bioreporter performance by splitting the lux operon. Anal. Bioanal. Chem. 400, 1071-1082.