Radiation-induced mitotic cell death and glioblastoma radioresistance: A new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1alpha and survivin in U87 cells

European Journal of Cancer

Volumn 49, Issue 13, 2013, Pages 2884-2891

  Lanvin, Olivia ^a   Monferran, Sylvie ^a,c   Delmas, Caroline ^a,b   Couderc, Bettina ^b,c   Toulas, Christine ^a,b   Cohen Jonathan Moyal, Elizabeth ^a,b,c  

^a INSERM   (France)

^b INSTITUT CLAUDIUS REGAUD   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

1alpha; Centrosome duplication; Glioblastoma; Hypoxia inducible factor; Integrin linked kinase; Ionising radiations; Mitotic cell death; Survivin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DOXYCYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTEGRIN LINKED KINASE; SEPANTRONIUM BROMIDE; SHORT HAIRPIN RNA; SURVIVIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL SURVIVAL; CENTROSOME; CONTROLLED STUDY; GENE AMPLIFICATION; GENE DUPLICATION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; MULTINUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR CELL LINE;

CENTROSOME DUPLICATION; GLIOBLASTOMA; HYPOXIA-INDUCIBLE FACTOR 1ALPHA; INTEGRIN-LINKED KINASE; IONISING RADIATIONS; MITOTIC CELL DEATH; SURVIVIN;

CELL DEATH; CELL LINE, TUMOR; CENTROSOME; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITOR OF APOPTOSIS PROTEINS; MITOSIS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84881093455     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.05.003     Document Type: Article

References (31)

1. E.C. Jonathan, E.J. Bernhard, and W.G. McKenna How does radiation kill cells? Curr Opin Chem Biol 3 1 1999 77 83
2. C. Delmas, C. Heliez, and E. Cohen-Jonathan Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation Int J Cancer 100 1 2002 43 48
3. I.B. Roninson, E.V. Broude, and B.D. Chang If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells Drug Resist Updat 4 5 2001 303 313
4. N. Sato, K. Mizumoto, and M. Nakamura A possible role for centrosome overduplication in radiation-induced cell death Oncogene 19 46 2000 5281 5290
5. N. Sato, K. Mizumoto, M. Nakamura, and M. Tanaka Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells Exp Cell Res 255 2 2000 321 326
6. J. Milia, F. Teyssier, and F. Dalenc Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication Cell Death Differ 12 5 2005 492 501
7. S. Monferran, N. Skuli, and C. Delmas Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB Int J Cancer 123 2 2008 357 364
8. A.B. Fielding, I. Dobreva, P.C. McDonald, L.J. Foster, and S. Dedhar Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization J Cell Biol 180 4 2008 681 689
9. V. Gkretsi, W.M. Mars, and W.C. Bowen Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis Hepatology 45 4 2007 1025 1034
10. L.A. Edwards, J. Woo, and L.A. Huxham Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK) Mol Cancer Ther 7 1 2008 59 70
11. A.B. Fielding, S. Lim, K. Montgomery, I. Dobreva, and S. Dedhar A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells Oncogene 30 5 2011 521 534
12. N. Skuli, S. Monferran, and C. Delmas Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells Cancer Res 66 1 2006 482 489
13. F. Li, G. Ambrosini, and E.Y. Chu Control of apoptosis and mitotic spindle checkpoint by survivin Nature 396 6711 1998 580 584
14. R.R. Adams, M. Carmena, and W.C. Earnshaw Chromosomal passengers and the (aurora) ABCs of mitosis Trends Cell Biol 11 2 2001 49 54
15. E. Beltrami, J. Plescia, J.C. Wilkinson, C.S. Duckett, and D.C. Altieri Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis J Biol Chem 279 3 2004 2077 2084
16. T. Saito, S. Hama, and H. Izumi Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells Br J Cancer 98 2 2008 345 355
17. X.H. Peng, P. Karna, Z. Cao, B.H. Jiang, M. Zhou, and L. Yang Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression J Biol Chem 281 36 2006 25903 25914
18. Y. Hu, K. Kirito, and K. Yoshida Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan Mol Cancer Ther 8 8 2009 2329 2338
19. H. Vakifahmetoglu, M. Olsson, and B. Zhivotovsky Death through a tragedy: mitotic catastrophe Cell Death Differ 15 7 2008 1153 1162
20. S.M. Pontier, L. Huck, and D.E. White Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer Oncogene 29 23 2010 3374 3385
21. S.L. Lee, E.C. Hsu, and C.C. Chou Identification and characterization of a novel integrin-linked kinase inhibitor J Med Chem 54 18 2011 6364 6374
22. S. Shoji, H. Watanabe, and O. Katoh Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos Int J Radiat Biol 73 6 1998 705 709
23. E. Berra, E. Benizri, A. Ginouves, V. Volmat, D. Roux, and J. Pouyssegur HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia EMBO J 22 16 2003 4082 4090
24. W.Y. Kim, S.H. Oh, J.K. Woo, W.K. Hong, and H.Y. Lee Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha Cancer Res 69 4 2009 1624 1632
25. C. Nakada, Y. Tsukamoto, and K. Matsuura Overexpression of miR-210, a downstream target of HIF1alpha, causes centrosome amplification in renal carcinoma cells J Pathol 224 2 2011 280 288
26. W.A. AbouAlaiwi, S. Ratnam, R.L. Booth, J.V. Shah, and S.M. Nauli Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation Hum Mol Genet 20 2 2011 354 367
27. I. Eke, F. Leonhardt, K. Storch, S. Hehlgans, and N. Cordes The small molecule inhibitor QLT0267 Radiosensitizes squamous cell carcinoma cells of the head and neck PLoS One 4 7 2009 e6434
28. T. Iwasa, I. Okamoto, and M. Suzuki Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines Clin Cancer Res 14 20 2008 6496 6504
29. A. Abdollahi, D.W. Griggs, and H. Zieher Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy Clin Cancer Res 11 17 2005 6270 6279
30. T. Mikkelsen, C. Brodie, and S. Finniss Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency Int J Cancer 124 11 2009 2719 2727
31. R. Stupp, M.E. Hegi, and B. Neyns Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma J Clin Oncol 28 16 2010 2712 2718