The zinc-binding motif of human RECQ5β suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme

Biochemical Journal

Volumn 412, Issue 3, 2008, Pages 425-433

  Ren, Hua ^a,b   Dou, Shuo Xing ^c   Zhang, Xing Dong ^c   Wang, Peng Ye ^c   Kanagaraj, Radhakrishnan ^d   Liu, Jie Lin ^a   Janscak, Pavel ^d   Hu, Jin Shan ^e   Xi, Xu Guang ^a  

^a CNRS   (France)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c INSTITUTE OF PHYSICS   (China)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

DNA annealing; DNA unwinding; Intramolecular regulation; RecQ helicase; Zinc finger motif

Indexed keywords

ANNEALING; BINDING ENERGY; DIGITAL SIGNAL PROCESSING; DNA; ENZYMES; FOOD ADDITIVES; GENES; LAWS AND LEGISLATION; MODULATION; NUCLEIC ACIDS; ORGANIC ACIDS; QUALITY ASSURANCE; RELIABILITY; STEEL ANALYSIS; ZINC; ZINC SULFIDE;

ANNEALING ACTIVITY; BINDING MOTIFS; CATALYTIC ACTIVITIES; DNA UNWINDING; DNA-BINDING; GENOMIC INTEGRITY; HELICASE; HELICASE ACTIVITIES; HELICASES; QUANTITATIVE MEASUREMENTS; STRUCTURAL SIMILARITY (SSIM);

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATASE; RECQ HELICASE; RECQ5BETA PROTEIN; ZINC BINDING PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA BINDING; DNA DENATURATION; DOWNSTREAM PROCESSING; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; PRIORITY JOURNAL; ZINC FINGER MOTIF;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; DNA, SINGLE-STRANDED; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECQ HELICASES; VARIATION (GENETICS); ZINC FINGERS;

EID: 45349089153     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071150     Document Type: Article

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