Inhibitory impacts of chemically modified tetracycline-3 and underlying mechanism in human cervical cancer cells

Anti-Cancer Drugs

Volumn 24, Issue 8, 2013, Pages 799-809

  Zhao, Lin ^a   Xu, Jiaying ^a   Yang, Yang ^a   Chong, Yu ^a   Liu, Chang ^a   Jiao, Yang ^a   Fan, Saijun ^a,b  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

apoptosis; cell cycle; cervical cancer; chemically modified tetracycline 3; NF B

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CHEMICALLY MODIFIED TETRACYCLINE 3; CYCLIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE INHIBITORS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; OXIDATIVE STRESS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINES; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 84881060646     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e328362b1be     Document Type: Article

References (46)

1. Zhang Z, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, et al. A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecol Oncol 2011; 123:401-406.
2. Clarke MA, Rodriguez AC, Gage JC, Herrero R, Hildesheim A, Wacholder S, et al. A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection. BMC Infect Dis 2012; 12:33.
3. Michelli E, Tellez L, Mendoza JA, Jurgensen C, Munoz M, Perez S, et al. Comparative analysis of three methods for HPV DNA detection in cervical samples. Invest Clin 2011; 52:344-357.
4. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991; 2:297-321.
5. Lokeshwar BL, Selzer MG, Zhu BQ, Block NL, Golub LM. Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model. Int J Cancer 2002; 98:297-309.
6. Gu Y, Lee HM, Roemer EJ, Musacchia L, Golub LM, Simon SR. Inhibition of tumor cell invasiveness by chemically modified tetracyclines. Curr Med Chem 2001; 8:261-270.
7. Lokeshwar BL. MMP inhibition in prostate cancer. Ann N Y Acad Sci 1999; 878:271-289.
8. Lokeshwar BL, Houston-Clark HL, Selzer MG, Block NL, Golub LM. Potential application of a chemically modified non-antimicrobial tetracycline (CMT-3) against metastatic prostate cancer. Adv Dent Res 1998; 12: 97-102.
9. Lokeshwar BL, Escatel E, Zhu B. Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3). Curr Med Chem 2001; 8:271-279.
10. Meng Q, Xu J, Goldberg ID, Rosen EM, Greenwald RA, Fan S. Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells. Clin Exp Metastasis 2000; 18:139-146.
11. Seftor RE, Seftor EA, De Larco JE, Kleiner DE, Leferson J, Stetler-Stevenson WG, et al. Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis. Clin Exp Metastasis 1998; 16:217-225.
12. Selzer MG, Zhu B, Block NL, Lokeshwar BL. CMT-3 a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer. Ann N Y Acad Sci 1999; 878:678-682.
13. Lokeshwar BL. Chemically modified non-antimicrobial tetracyclines are multifunctional drugs against advanced cancers. Pharmacol Res 2011; 63:146-150.
14. Syed S, Takimoto C, Hidalgo M, Rizzo J, Kuhn JG, Hammond LA, et al. A phase I and pharmacokinetic study of Col-3 (Metastat), an oral tetracycline derivative with potent matrix metalloproteinase and antitumor properties. Clin Cancer Res 2004; 10:6512-6521.
15. Kongara S, Karantza V. The interplay between autophagy and ROS in tumorigenesis. Front Oncol 2012; 2:171.
16. Wu S, Xing D. Mechanism of mitochondrial membrane permeabilization during apoptosis under photofrin-mediated photodynamic therapy. J Xray Sci Technol 2012; 20:363-372.
17. Fiandalo MV, Kyprianou N. Caspase control: protagonists of cancer cell apoptosis. Exp Oncol 2012; 34:165-175.
18. Samy RP, Rajendran P, Li F, Anandi NM, Stiles BG, Ignacimuthu S, et al. Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-kappaB pathway. PLoS One 2012; 7:e48514.
19. Xu L, Russu WA. Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-kappaB activation and their anti-cancer activities. Bioorg Med Chem 2013; 21:540-546.
20. Jiao Y, Ge CM, Meng QH, Cao JP, Tong J, Fan SJ. Dihydroartemisinin is an inhibitor of ovarian cancer cell growth. Acta Pharmacol Sin 2007; 28:1045-1056.
21. Marcial BL, Sousa SF, Barbosa IL, Dos SHF, Ramos MJ. Chemically modified tetracyclines as inhibitors of MMP-2 matrix metalloproteinase: a molecular and structural study. J Phys Chem B 2011; 116:13644-13654.
22. Venkatraman M, Anto RJ, Nair A, Varghese M, Karunagaran D. Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Mol Carcinog 2005; 44:51-59.
23. Funaoka K, Shindoh M, Yamashita T, Fujinaga K, Amemiya A, Totsuka Y. High-risk HPV-positive human cancer cell lines show different sensitivity to cisplatin-induced apoptosis correlated with the p21Waf1/Cip1 level. Cancer Lett 1996; 108:15-23.
24. Burger H, Nooter K, Boersma AW, Kortland CJ, Stoter G. Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines. Int J Cancer 1997; 73:592-599.
25. Panieri E, Gogvadze V, Norberg E, Venkatesh R, Orrenius S, Zhivotovsky B. Reactive oxygen species generated in different compartments induce cell death, survival or senescence. Free Radic Biol Med 2013; 57:176-187.
26. Tatarkova Z, Kuka S, Petras M, Racay P, Lehotsky J, Dobrota D, et al. Why mitochondria are excellent targets for cancer therapy. Klin Onkol 2012; 25:421-426.
27. Lau AT, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 2008; 104:657-667.
28. Paul S, Sengupta S, Bandyopadhyay TK, Bhattacharyya A. Stevioside induced ROS-mediated apoptosis through mitochondrial pathway in human breast cancer cell line MCF-7. Nutr Cancer 2012; 64:1087-1094.
29. Visavadiya NP, McEwen ML, Pandya JD, Sullivan PG, Gwag BJ, Springer JE. Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage. Toxicol In Vitro 2012; 27:788-797.
30. Li P, Nijhawan D, Wang X. Mitochondrial activation of apoptosis. Cell 2004; 116 (Suppl):S57-S59.
31. Neoh CA, Wang RY, Din ZH, Su JH, Chen YK, Tsai FJ, et al. Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells. Mar Drugs 2012; 10:2893-2911.
32. Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006; 25:4798-4811.
33. Onoda T, Ono T, Dhar DK, Yamanoi A, Nagasue N. Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and-independent apoptosis in human colon cancer cells. Int J Cancer 2006; 118:1309-1315.
34. Herold MJ, Kuss AW, Kraus C, Berberich I. Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells. J Immunol 2002; 168:3902-3909.
35. Das L, Vinayak M. Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-kappaB signalling in lymphoma-bearing mice. Biosci Rep 2012; 32:161-170.
36. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3:221-227.
37. Jin HR, Jin SZ, Cai XF, Li D, Wu X, Nan JX, et al. Cryptopleurine targets NF-kappaB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis. PLoS One 2012; 7:e40355.
38. Ducut SJL, Bottero V, Young DB, Shevchenko A, Mercurio F, Verma IM. Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science 2004; 304:1963-1967.
39. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 2001; 8:759-766.
40. Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 1995; 15:2612-2624.
41. Akli S, Zhang XQ, Bondaruk J, Tucker SL, Czerniak PB, Benedict WF, et al. Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer. Cell Cycle 2012; 11:1468-1476.
42. Nakayama KI, Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006; 6:369-381.
43. Sancho R, Jandke A, Davis H, Diefenbacher ME, Tomlinson I, Behrens A. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 2010; 139:929-941.
44. Cheng Y, Li G. Role of the ubiquitin ligase Fbw7 in cancer progression. Cancer Metastasis Rev 2012; 31:75-87.
45. Hahnvajanawong C, Ketnimit S, Pattanapanyasat K, Anantachoke N, Sripa B, Pinmai K, et al. Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin. Biol Pharm Bull 2012; 35:1914-1925.
46. Janbandhu VC, Singh AK, Mukherji A, Kumar V. p65 negatively regulates transcription of the cyclin E gene. J Biol Chem 2010; 285:17453-17464.