Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines

International Journal of Cancer

Volumn 73, Issue 4, 1997, Pages 592-599

  Burger, Herman ^a   Nooter, Kees ^a,b   Boersma, Antonius W M ^a   Kortland, Christine J ^a   Stoter, Gerrit ^a  

^a ERASMUS MC CANCER INSTITUTE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DISEASE ASSOCIATION; DNA DAMAGE; GENE EXPRESSION; GENOTOXICITY; GERM CELL TUMOR; IONIZING RADIATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSACTIVATION; TRANSGENIC MOUSE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CISPLATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA ADDUCTS; DNA, NEOPLASM; GENES, P53; GERMINOMA; HUMANS; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; TESTICULAR NEOPLASMS; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031466945     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19971114)73:4<592::AID-IJC22>3.0.CO;2-A     Document Type: Article

References (25)

1. BOERSMA, A.W.M., NOOTER, K., BURGER, H., KORTLAND, C.J. and STOTER, G., Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ cell tumour cell line NT2, as quantitated by flow cytometry. Cytometry, 27, 275-282 (1997).
2. BOERSMA, A.W.M., NOOTER, K., OOSTRUM, R.G. and STOTER, G., Quantification of apoptotic cells with FITC-labeled Annexin V in CHO cells treated with cisplatin. Cytometry, 24, 123-130 (1996).
3. CLARKE, A.R., PURDIE, C.A., HARRISON, D.J., MORRIS, R.G., BIRD, C.C., HOOPER, M.L. and WYLLIE, A.H., Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362, 849-852 (1993).
4. CRESTA, C.M., MASTERS. J.R.W. and HICKMAN, J.A., Hypersensitivity of human testicular tumours to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res., 56, 1834-1841 (1996).
5. DAMJANOV, I., HORVAT, B. and GIBAS, Z., Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumour-derived cell line, NCCIT. Lab. Invest., 68, 220-232 (1993).
6. EINHORN, L.H., Treatment of testicular cancer: a new and improved model. J. clin. Oncol., 8, 1777-1781 (1990).
7. FISHER, D.E., Apoptosis in cancer therapy: crossing the threshold. Cell, 78, 539-542 (1994).
8. HARRIS, C.C., Structure and function of the p53 tumour suppressor gene: clues for rational cancer therapeutic strategies. J. nat. Cancer Inst., 88, 1442-1452 (1996).
9. HILL, B.T., SCANLON, K.J., HANSSON, J., HARSTRICK, A., PERA, M., FICHTINGER-SCHEPMAN, A.M.J. and SHELLARD, S.A., Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients. Europ. J. Cancer, 30A, 832-837 (1994).
10. ISHIKAWA, T., WRIGHT, C.D. and ISHIZUKA, H., GS-X pump is functionally overexpressed in cis-diamminnedichloroplatinum(II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J. biol. Chem., 269, 29085-29093 (1994).
11. KHANNA, K.K., WIE, T., SONG, Q., BURROWS, S.R., MOSS, D.J., KRAJEWSKI, S., REED, J.C. and LAVIN, M.F., Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell Death Differentiation, 3, 315-322 (1996).
12. KÖBERLE, B., PAYNE, J., GRIMALDI, K.A., HARTLEY, J.A. and MASTERS, J.R.W., DNA repair in cisplatin-sensitive and resistant human cell lines measured in specific genes by quantitative polymerase chain reaction. Biochem. Pharmacol., 52, 1729-1734 (1996).
13. KORSMEYER, S.J., Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood, 80, 879-886 (1992).
14. KUCZYK, M.A., SERTH, J., BOKEMEYER, C., JONASSEN, J., MACHTENS, S., WERNER, M. and JONAS, U., Alterations of the p53 tumour suppressor gene in carcinoma in situ of the testis. Cancer, 78, 1958-1966 (1996).
15. LOWE, S.W., RULEY, H.E., JACKS, T. and HOUSMAN, D.E., p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967 (1993).
16. MARTIN, S.J. and GREEN, D.R., Protease activation during apoptosis: death by a thousand cuts? Cell, 82, 349-352 (1995).
17. MASTERS, J.R.W., OSBORNE, E.J., WALKER, M.C. and PARRIS, C.N., Hypersensitivity of human testis tumour cell lines to chemotherapeutic drugs. Int. J. Cancer, 53, 340-346 (1993).
18. MILLER, S.A., DYKES, D.D. and POLESKY, H.F., A simple salting out procedure for extracting DNA from human nucleated cells. Nucl. Acids Res., 16, 1215 (1988).
19. MIYASHITA, T., KRAJEWSKI, S., KRAJEWSKI, M., WANG, H.G., LIN, H.K., LIEBERMANN, D.A., HOFMANN, B. and REED, J.C., Tumour suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805 (1994).
20. PENG, H.Q., HOGG, D., MALKIN, D., BAILEY, D., GALLIE, B.L., BULBUL, M., JEWETT, M., BUCHANAN, J. and GROSS, P.E., Mutations of the p53 gene do not occur in testis cancer. Cancer Res., 53, 3574-3578 (1993).
21. REED, J.C., MIYASHITA, T., TAKAYAMA, S., WANG, H.-G., SATO, T., KRAJEWSKI, S., AIMÉ-SEMPÉ, C., BODRUG, S., KITADA, S. and HANADA, M., Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance therapy. J. cell. Biochem., 60, 23-32 (1996).
22. SARK, M.W.J., TIMMER-BOSSCHA, H., MEIJER, C., UGES, D.R.A., SLUITER, W.J., PETERS, W.H.M., MULDER, N.H. and DE VRIES, E.G.E., Cellular basis for differential sensitivity to cisplatin in human germ cell tumour and colon carcinoma cell lines. Brit. J. Cancer, 71, 684-690 (1995).
23. WANG, N., PERKINS, K.L., BRONSON, D.L. and FRALEY, E.E., Cytogenetic evidence for premeiotic transformation of human testicular cancers. Cancer Res., 41, 2135-2140 (1981).
24. ZAKUT-HOURI, R., BIENZ-TADMOR, B., GIVOL, D. and OHREN, M., Human p53 cellular tumour antigen: cDNA sequence and expression in COS cells. EMBO J., 4, 1251-1255 (1985).
25. ZHAN, Q., FAN. S., BAE, I., GUILLOUF, C., LIEBERMANN, D.A., O'CONNOR, P.M. and FORNACE, A.J., Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9, 3743-3751 (1994).