Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

Advanced Drug Delivery Reviews

Volumn 65, Issue 8, 2013, Pages 1074-1085

  Lietz, Christopher B ^a   Gemperline, Erin ^a   Li, Lingjun ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

ADME; Molecular imaging; Pharmaceuticals; PK PD; Quantitative mass spectrometry; Spatial distribution

Indexed keywords

ADME; EMERGING TECHNOLOGIES; MASS SPECTROMETRIC IMAGING; MICROAUTORADIOGRAPHY; PHARMACEUTICAL SCIENCE; PK/PD; QUANTITATIVE MASS SPECTROMETRIES; TRADITIONAL TECHNIQUES;

DRUG DELIVERY; DRUG PRODUCTS; METABOLITES; MOLECULAR IMAGING; RADIOGRAPHY; SPATIAL DISTRIBUTION;

MASS SPECTROMETRY;

4 BORONOPHENYLALANINE; ADENOSINE TRIPHOSPHATE; CLOZAPINE; GAMMA INTERMEDIN; LEVACECARNINE; NEUROPEPTIDE; OLEIC ACID; OXYTOCIN; SIGNAL PEPTIDE; THEOPHYLLINE; VASOPRESSIN;

ACCURACY; CAPILLARY ELECTROPHORESIS; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RESEARCH; FREEZING; HUMAN; IONIZATION; MASS SPECTROMETRY; MASS SPECTROMETRY IMAGING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEASUREMENT ERROR; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TISSUE SECTION; WHOLE BODY AUTORADIOGRAPHY;

EID: 84881028758     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2013.04.009     Document Type: Review

References (112)

1. Solon E.G. Use of radioactive compounds and autoradiography to determine drug tissue distribution. Chem. Res. Toxicol. 2012, 25:543-555.
2. Solon E.G., Schweitzer A., Stoeckli M., Prideaux B. Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J. 2010, 12:11-26.
3. Roffey S.J., Obach R.S., Gedge J.I., Smith D.A. What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs. Drug Metab. Rev. 2007, 39:17-43.
4. Greer T., Sturm R., Li L.J. Mass spectrometry imaging for drugs and metabolites. J. Proteomics 2011, 74:2617-2631.
5. Seeley E.H., Caprioli R.M. MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives. Trends Biotechnol. 2011, 29:136-143.
6. Chaurand P. Imaging mass spectrometry of thin tissue sections: a decade of collective efforts. J. Proteomics 2012, 75:4883-4892.
7. McDonnell L.A., Heeren R.M. Imaging mass spectrometry. Mass Spectrom. Rev. 2007, 26:606-643.
8. Hsieh Y., Chen J., Korfmacher W.A. Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry. J. Pharmacol. Toxicol. Methods 2007, 55:193-200.
9. van Hove E.R.A., Smith D.F., Heeren R.M.A. A concise review of mass spectrometry imaging. J. Chromatogr. A 2010, 1217:3946-3954.
10. Castellino S., Groseclose M.R., Wagner D. MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis 2011, 3:2427-2441.
11. Wiseman J.M., Ifa D.R., Song Q.Y., Cooks R.G. Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. Angew. Chem. Int. Ed Engl. 2006, 45:7188-7192.
12. Seeley E.H., Caprioli R.M. Molecular imaging of proteins in tissues by mass spectrometry. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:18126-18131.
13. Troendle F.J., Reddick C.D., Yost R.A. Detection of pharmaceutical compounds in tissue by matrix-assisted laser desorption/ionization and laser desorption/chemical ionization tandem mass spectrometry with a quadrupole ion trap. J. Am. Soc. Mass Spectrom. 1999, 10:1315-1321.
14. Rohner T.C., Staab D., Stoeckli M. MALDI mass spectrometric imaging of biological tissue sections. Mech. Ageing Dev. 2005, 126:177-185.
15. Gross J.H. Mass Spectrometry 2004, Springer, Berlin.
16. 60 secondary ion Fourier transform ion cyclotron resonance mass spectrometry. Anal. Chem. 2011, 83:9552-9556.
17. Manicke N.E., Dill A.L., Ifa D.R., Cooks R.G. High-resolution tissue imaging on an orbitrap mass spectrometer by desorption electrospray ionization mass spectrometry. J. Mass Spectrom. 2010, 45:223-226.
18. Clode P.L., Kilburn M.R., Jones D.L., Stockdale E.A., Cliff J.B., Herrmann A.M., Murphy D.V. In situ mapping of nutrient uptake in the rhizosphere using nanoscale secondary ion mass spectrometry. Plant Physiol. 2009, 151:1751-1757.
19. Marshall A.G., Hendrickson C.L., Jackson G.S. Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom. Rev. 1998, 17:1-35.
20. Hu Q.Z., Noll R.J., Li H.Y., Makarov A., Hardman M., Cooks R.G. The Orbitrap: a new mass spectrometer. J. Mass Spectrom. 2005, 40:430-443.
21. Glauser G., Veyrat N., Rochat B., Wolfender J.L., Turlings T.C. Ultra-high pressure liquid chromatography-mass spectrometry for plant metabolomics: a systematic comparison of high-resolution quadrupole-time-of-flight and single stage Orbitrap mass spectrometers. J. Chromatogr. A 2012, 10.1016/j.chroma.2012.12.009.
22. Hopfgartner G., Varesio E., Stoeckli M. Matrix-assisted laser desorption/ionization mass spectrometric imaging of complete rat sections using a triple quadrupole linear ion trap. Rapid Commun. Mass Spectrom. 2009, 23:733-736.
23. Stoeckli M., Staab D., Schweitzer A. Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections. Int. J. Mass Spectrom. 2007, 260:195-202.
24. Casadonte R., Caprioli R.M. Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometry. Nat. Protoc. 2011, 6:1695-1709.
25. Schwartz S.A., Reyzer M.L., Caprioli R.M. Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J. Mass Spectrom. 2003, 38:699-708.
26. Sugiura Y., Zaima N., Setou M., Ito S., Yao I. Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry. Anal. Bioanal. Chem. 2012, 403:1851-1861.
27. Castaing R., Slodzian G. Microanalyse par émission ionique secondaire. J. Microsc. 1962, 1:395-410.
28. Pachuta S.J., Cooks R.G. Mechanisms in molecular SIMS. Chem. Rev. 1987, 87:647-669.
29. Touboul D., Halgand F., Brunelle A., Kersting R., Tallarek E., Hagenhoff B., Laprevote O. Tissue molecular ion imaging by gold cluster ion bombardment. Anal. Chem. 2004, 76:1550-1559.
30. Ostrowski S.G., Szakal C., Kozole J., Roddy T.P., Xu J.Y., Ewing A.G., Winograd N. Secondary ion MS imaging of lipids in picoliter vials with a buckminsterfullerene ion source. Anal. Chem. 2005, 77:6190-6196.
31. Keune K., Boon J.J. Enhancement of the static SIMS secondary ion yields of lipid moieties by ultrathin gold coating of aged oil paint surfaces. Surf. Interface Anal. 2004, 36:1620-1628.
32. Nygren H., Malmberg P., Kriegeskotte C., Arlinghaus H.F. Bioimaging TOF-SIMS: localization of cholesterol in rat kidney sections. FEBS Lett. 2004, 566:291-293.
33. Kim Y.P., Oh E., Shon H.K., Moon D.W., Lee T.G., Kim H.S. Gold nanoparticle-enhanced secondary ion mass spectrometry and its bio-applications. Appl. Surf. Sci. 2008, 255:1064-1067.
34. Delcorte A., Bour J., Aubriet F., Muller J.F., Bertrand P. Sample metallization for performance improvement in desorption/ionization of kilodalton molecules: quantitative evaluation, imaging secondary ion MS, and laser ablation. Anal. Chem. 2003, 75:6875-6885.
35. Wu K.J., Odom R.W. Matrix-enhanced secondary ion mass spectrometry: a method for molecular analysis of solid surfaces. Anal. Chem. 1996, 68:873-882.
36. Szymczak W., Wittmaack K. Effect of water treatment on analyte and matrix ion yields in matrix-assisted time-of-flight secondary ion mass spectrometry: the case of insulin in and on hydroxycinnamic acid. Rapid Commun. Mass Spectrom. 2002, 16:2025-2033.
37. Adriaensen L., Vangaever F., Lenaerts J., Gijbels R. Matrix-enhanced secondary ion mass spectrometry: the influence of MALDI matrices on molecular ion yields of thin organic films. Rapid Commun. Mass Spectrom. 2005, 19:1017-1024.
38. ToF SIMS: Surface analysis by mass spectrometry 2001, IM Publications and Surface Spectra Limited, Chichester, Manchester.
39. Shanta S.R., Kim Y., Kim Y.H., Kim K.P. Application of MALDI tissue imaging of drugs and metabolites: a new frontier for molecular histology. Biomol. Ther. 2011, 19:149-154.
40. Goto-Inoue N., Hayasaka T., Zaima N., Setou M. Imaging mass spectrometry for lipidomics. BBA-Mol. Cell Biol. Lipids 2011, 1811:961-969.
41. Chen R.B., Li L.J. Mass spectral imaging and profiling of neuropeptides at the organ and cellular domains. Anal. Bioanal. Chem. 2010, 397:3185-3193.
42. Chaurand P., Norris J.L., Cornett D.S., Mobley J.A., Caprioli R.M. New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J. Proteome Res. 2006, 5:2889-2900.
43. Tanaka K., Waki H., Ido Y., Akita S., Yoshida Y., Yoshida T., Matsuo T. Protein and polymer analyses up to m/z 100,000 by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1988, 2:151-153.
44. Laiko V.V., Baldwin M.A., Burlingame A.L. Atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2000, 72:652-657.
45. Karas M., Kruger R. Ion formation in MALDI: the cluster ionization mechanism. Chem. Rev. 2003, 103:427-439.
46. Knochenmuss R., Zenobi R. MALDI ionization: the role of in-plume processes. Chem. Rev. 2003, 103:441-452.
47. Vertes A., Nemes P., Shrestha B., Barton A.A., Chen Z.Y., Li Y. Molecular imaging by Mid-IR laser ablation mass spectrometry. Appl. Phys. A: Mater. 2008, 93:885-891.
48. Robichaud G., Barry J.A., Garrard K.P., Muddiman D.C. Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) imaging source coupled to a FT-ICR mass spectrometer. J. Am. Soc. Mass Spectrom. 2013, 24:92-100.
49. Jackson S.N., Ugarov M., Egan T., Post J.D., Langlais D., Albert Schultz J., Woods A.S. MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J. Mass Spectrom. 2007, 42:1093-1098.
50. Knochenmuss R., Karbach V., Wiesli U., Breuker K., Zenobi R. The matrix suppression effect in matrix-assisted laser desorption/ionization: application to negative ions and further characteristics. Rapid Commun. Mass Spectrom. 1998, 12:529-534.
51. Luxembourg S.L., McDonnell L.A., Duursma M.C., Guo X.H., Heeren R.M.A. Effect of local matrix crystal variations in matrix-assisted ionization techniques for mass spectrometry. Anal. Chem. 2003, 75:2333-2341.
52. Wang H.Y.J., Post S.N.J.J., Woods A.S. A minimalist approach to MALDI imaging of glycerophospholipids and sphingolipids in rat brain sections. Int. J. Mass Spectrom. 2008, 278:143-149.
53. Baluya D.L., Garrett T.J., Yost R.A. Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry. Anal. Chem. 2007, 79:6862-6867.
54. Yamada Y., Hidefumi K., Shion H., Oshikata M., Haramaki Y. Distribution of chloroquine in ocular tissue of pigmented rat using matrix-assisted laser desorption/ionization imaging quadrupole time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25:1600-1608.
55. Schuerenberg M., Luebbert C., Deininger S.O., Ketterlinus R., Suckau D. MALDI tissue imaging: mass spectrometric localization of biomarkers in tissue slices. Nat. Methods 2007, 4:iii-iv.
56. Grove K.J., Frappier S.L., Caprioli R.M. Matrix pre-coated MALDI MS targets for small molecule imaging in tissues. J. Am. Soc. Mass Spectrom. 2011, 22:192-195.
57. Hankin J.A., Barkley R.M., Murphy R.C. Sublimation as a method of matrix application for mass spectrometric imaging. J. Am. Soc. Mass Spectrom. 2007, 18:1646-1652.
58. Puolitaival S.M., Burnum K.E., Cornett D.S., Caprioli R.M. Solvent-free matrix dry-coating for MALDI imaging of phospholipids. J. Am. Soc. Mass Spectrom. 2008, 19:882-886.
59. Trimpin S., Herath T.N., Inutan E.D., Wager-Miller J., Kowalski P., Claude E., Walker J.M., Mackie K. Automated solvent-free matrix deposition for tissue imaging by mass spectrometry. Anal. Chem. 2010, 82:359-367.
60. Takats Z., Wiseman J.M., Gologan B., Cooks R.G. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306:471-473.
61. Alberici R.M., Simas R.C., Sanvido G.B., Romao W., Lalli P.M., Benassi M., Cunha I.B.S., Eberlin M.N. Ambient mass spectrometry: bringing MS into the "real world". Anal. Bioanal. Chem. 2010, 398:265-294.
62. Dole M., Mack L.L., Hines R.L. Molecular beams of macroions. J. Chem. Phys. 1968, 49. (2240-&).
63. Cooks R.G., Jo S.C., Green J. Collisions of organic ions at surfaces. Appl. Surf. Sci. 2004, 231:13-21.
64. Takats Z., Wiseman J.M., Cooks R.G. Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J. Mass Spectrom. 2005, 40:1261-1275.
65. Wiseman J.M., Ifa D.R., Zhu Y.X., Kissinger C.B., Manicke N.E., Kissinger P.T., Cooks R.G. Desorption electrospray ionization mass spectrometry: imaging drugs and metabolites in tissues. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:18120-18125.
66. Cotte-Rodriguez I., Takats Z., Talaty N., Chen H.W., Cooks R.G. Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization. Anal. Chem. 2005, 77:6755-6764.
67. Wu C., Ifa D.R., Manicke N.E., Cooks R.G. Rapid, direct analysis of cholesterol by charge labeling in reactive desorption electrospray ionization. Anal. Chem. 2009, 81:7618-7624.
68. Touboul D., Brunelle A., Laprevote O. Structural analysis of secondary ions by post-source decay in time-of-flight secondary ion mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20:703-709.
69. Campbell D.I., Ferreira C.R., Eberlin L.S., Cooks R.G. Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization. Anal. Bioanal. Chem. 2012, 404:389-398.
70. Stoeckli M., Staab D., Schweitzer A., Gardiner J., Seebach D. Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. 2007, 18:1921-1924.
71. Enthaler B., Pruns J.K., Wessel S., Rapp C., Fischer M., Wittern K.P. Improved sample preparation for MALDI-MSI of endogenous compounds in skin tissue sections and mapping of exogenous active compounds subsequent to ex-vivo skin penetration. Anal. Bioanal. Chem. 2012, 402:1159-1167.
72. Kreye F., Hamm G., Karrout Y., Legouffe R., Bonnel D., Siepmann F., Siepmann J. MALDI-TOF MS imaging of controlled release implants. J. Control. Release 2012, 161:98-108.
73. Drexler D.M., Tannehill-Gregg S.H., Wang L.F., Brock B.J. Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs. J. Pharmacol. Toxicol. Methods 2011, 63:205-208.
74. Heeren R.M., Smith D.F., Stauber J., Kukrer-Kaletas B., MacAleese L. Imaging mass spectrometry: hype or hope?. J. Am. Soc. Mass Spectrom. 2009, 20:1006-1014.
75. Hattori K., Kajimura M., Hishiki T., Nakanishi T., Kubo A., Nagahata Y., Ohmura M., Yachie-Kinoshita A., Matsuura T., Morikawa T., Nakamura T., Setou M., Suematsu M. Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. Antioxid. Redox Signal. 2010, 13:1157-1167.
76. Sokoloff L., Reivich M., Kennedy C., Des Rosiers M.H., Patlak C.S., Pettigrew K.D., Sakurada O., Shinohara M. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 1977, 28:897-916.
77. Koeniger S.L., Talaty N., Luo Y.P., Ready D., Voorbach M., Seifert T., Cepa S., Fagerland J.A., Bouska J., Buck W., Johnson R.W., Spanton S. A quantitation method for mass spectrometry imaging. Rapid Commun. Mass Spectrom. 2011, 25:503-510.
78. Nilsson A., Fehniger T.E., Gustavsson L., Andersson M., Kenne K., Marko-Varga G., Andren P.E. Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PLoS One 2010, 5.
79. Pirman D.A., Yost R.A. Quantitative tandem mass spectrometric imaging of endogenous Acetyl-L-carnitine from piglet brain tissue using an internal standard. Anal. Chem. 2011, 83:8575-8581.
80. Vismeh R., Waldon D.J., Teffera Y., Zhao Z.Y. Localization and quantification of drugs in animal tissues by use of desorption electrospray ionization mass spectrometry imaging. Anal. Chem. 2012, 84:5439-5445.
81. Lechene C., Hillion F., McMahon G., Benson D., Kleinfeld A.M., Kampf J.P., Distel D., Luyten Y., Bonventre J., Hentschel D., Park K.M., Ito S., Schwartz M., Benichou G., Slodzian G. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. J. Biol. 2006, 5:20.
82. Setou M., Shrivas K., Sroyraya M., Yang H., Sugiura Y., Moribe J., Kondo A., Tsutsumi K., Kimura Y., Kurabe N., Hayasaka T., Goto-Inoue N., Zaima N., Ikegami K., Sobhon P., Konishi Y. Developments and applications of mass microscopy. Med. Mol. Morphol. 2010, 43:1-5.
83. Chandra S., Lorey D.R., Smith D.R. Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered by two combined BNCT drugs: in vitro studies on human glioblastoma T98G cells. Radiat. Res. 2002, 157:700-710.
84. Altelaar A.F.M., Luxembourg S.L., McDonnell L.A., Piersma S.R., Heeren R.M.A. Imaging mass spectrometry at cellular length scales. Nat. Protoc. 2007, 2:1185-1196.
85. Spengler B., Hubert M. Scanning microprobe matrix-assisted laser desorption ionization (SMALDI) mass spectrometry: instrumentation for sub-micrometer resolved LDI and MALDI surface analysis. J. Am. Soc. Mass Spectrom. 2002, 13:735-748.
86. Bouschen W., Schulz O., Eikel D., Spengler B. Matrix vapor deposition/recrystallization and dedicated spray preparation for high-resolution scanning microprobe matrix-assisted laser desorption/ionization imaging mass spectrometry (SMALDI-MS) of tissue and single cells. Rapid Commun. Mass Spectrom. 2010, 24:355-364.
87. Richards A.L., Lietz C.B., Wager-Miller J.B., Mackie K., Trimpin S. Imaging mass spectrometry in transmission geometry. Rapid Commun. Mass Spectrom. 2011, 25:815-820.
88. Richards A.L., Lietz C.B., Wager-Miller J., Mackie K., Trimpin S. Localization and imaging of gangliosides in mouse brain tissue sections by laserspray ionization inlet. J. Lipid Res. 2012, 53:1390-1398.
89. Zavalin A., Todd E.M., Rawhouser P.D., Yang J., Norris J.L., Caprioli R.M. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J. Mass Spectrom. 2012, 47:1473-1481.
90. Li L.J., Sweedler J.V. Peptides in the brain: mass spectrometry-based measurement approaches and challenges. Annu. Rev. Anal. Chem. 2008, 1:451-483.
91. Ye H., Greer T., Li L. Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. J. Proteomics 2012, 75:5014-5026.
92. Rubakhin S.S., Greenough W.T., Sweedler J.V. Spatial profiling with MALDI MS: distribution of neuropeptides within single neurons. Anal. Chem. 2003, 75:5374-5380.
93. Guenther S., Rompp A., Kummer W., Spengler B. AP-MALDI imaging of neuropeptides in mouse pituitary gland with 5mu m spatial resolution and high mass accuracy. Int. J. Mass Spectrom. 2011, 305:228-237.
94. Hui L.M., Zhang Y.Z., Wang J.H., Cook A., Ye H., Nusbaum M.P., Li L.J. Discovery and functional study of a novel crustacean tachykinin neuropeptide. ACS Chem. Neurosci. 2011, 2:711-722.
95. Skold K., Svensson M., Kaplan A., Bjorkesten L., Astrom J., Andren P.E. A neuroproteomic approach to targeting neuropeptides in the brain. Proteomics 2002, 2:447-454.
96. Galli C., Racagni G. Use of microwave techniques to inactivate brain enzymes rapidly. Methods Enzymol. 1982, 86:635-642.
97. Che F.Y., Lim J., Pan H., Biswas R., Fricker L.D. Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary. Mol. Cell. Proteomics 2005, 4:1391-1405.
98. Colgrave M.L., Xi L., Lehnert S.A., Flatscher-Bader T., Wadensten H., Nilsson A., Andren P.E., Wijffels G. Neuropeptide profiling of the bovine hypothalamus: thermal stabilization is an effective tool in inhibiting post-mortem degradation. Proteomics 2011, 11:1264-1276.
99. Goodwin R.J., Lang A.M., Allingham H., Boren M., Pitt A.R. Stopping the clock on proteomic degradation by heat treatment at the point of tissue excision. Proteomics 2010, 10:1751-1761.
100. Ye H., Greer T., Li L.J. From pixel to voxel: a deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis 2011, 3:313-332.
101. Chen R.B., Hui L.M., Sturm R.M., Li L.J. Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging. J. Am. Soc. Mass Spectrom. 2009, 20:1068-1077.
102. Blatherwick E.Q., Van Berkel G.J., Pickup K., Johansson M.K., Beaudoin M.E., Cole R.O., Day J.M., Iverson S., Wilson I.D., Scrivens J.H., Weston D.J. Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism. Xenobiotica 2011, 41:720-734.
103. Wang B.X., Inutan E.D., Trimpin S. A new approach to high sensitivity liquid chromatography-mass spectrometry of peptides using nanoflow solvent assisted inlet ionization. J. Am. Soc. Mass Spectrom. 2012, 23:442-445.
104. Laskin J., Heath B.S., Roach P.J., Cazares L., Semmes O.J. Tissue imaging using nanospray desorption electrospray ionization mass spectrometry. Anal. Chem. 2012, 84:141-148.
105. Kiss A., Heeren R.M.A. Size, weight and position: ion mobility spectrometry and imaging MS combined. Anal. Bioanal. Chem. 2011, 399:2623-2634.
106. Trim P.J., Henson C.M., Avery J.L., McEwen A., Snel M.F., Claude E., Marshall P.S., West A., Princivalle A.P., Clench M.R. Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal. Chem. 2008, 80:8628-8634.
107. McLean J.A., Ridenour W.B., Caprioli R.M. Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. J. Mass Spectrom. 2007, 42:1099-1105.
108. Manier M.L., Reyzer M.L., Goh A., Dartois V., Via L.E., Barry C.E., Caprioli R.M. Reagent precoated targets for rapid in-tissue derivatization of the anti-tuberculosis drug isoniazid followed by MALDI imaging mass spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22:1409-1419.
109. Jones E.A., Deininger S.O., Hogendoorn P.C., Deelder A.M., McDonnell L.A. Imaging mass spectrometry statistical analysis. J. Proteomics 2012, 75:4962-4989.
110. Alexandrov T. MALDI imaging mass spectrometry: statistical data analysis and current computational challenges. BMC Bioinformatics 2012, 13(Suppl. 16):S11.
111. Thiele H., Heldmann S., Trede D., Strehlow J., Wirtz S., Dreher W., Berger J., Oetjen J., Kobarg J.H., Fischer B., Maass P. 2D and 3D MALDI-imaging: conceptual strategies for visualization and data mining. Biochim. Biophys. Acta 2013, 10.1016/j.bbapap.2013.01.040.
112. McDonnell L.A., Heeren R.M., Andren P.E., Stoeckli M., Corthals G.L. Going forward: increasing the accessibility of imaging mass spectrometry. J. Proteomics 2012, 75:5113-5121.