Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS

Journal of Mass Spectrometry

Volumn 47, Issue 11, 2012, Pages 1473-1481

  Zavalin, Andre ^a   Todd, Erik M ^a,b   Rawhouser, Patrick D ^a,b   Yang, Junhai ^a   Norris, Jeremy L ^a   Caprioli, Richard M ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

imaging mass spectrometry; single cell imaging; sub cellular; sub micron spatial resolution; transmission geometry

Indexed keywords

BIOLOGICAL TISSUES; DIRECT IMAGING; IMAGING MASS SPECTROMETRY; ION OPTICS; LASER DESORPTION IONIZATION; LASER SPOT SIZE; MALDI-MS; MOLECULAR IMAGES; OPTICAL LENS; SAMPLE PREPARATION; SINGLE CELLS; SPATIAL RESOLUTION; SUB-CELLULAR; SUBMICRON; TRANSMISSION GEOMETRIES;

GEOMETRY; IMAGE RESOLUTION; ION SOURCES; LASERS; SECONDARY ION MASS SPECTROMETRY; SOURCE SEPARATION; TISSUE;

MOLECULAR IMAGING;

GEOMETRY; HUMAN; HUMAN CELL; LASER; LASER CAPTURE MICRODISSECTION; LASER SURGERY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR IMAGING; OPTICAL RESOLUTION; PRIORITY JOURNAL; REVIEW; TRANSMISSION GEOMETRY ION SOURCE;

ANIMALS; BRAIN CHEMISTRY; EQUIPMENT DESIGN; HEK293 CELLS; HISTOLOGICAL TECHNIQUES; HUMANS; LIPIDS; MICE; MOLECULAR IMAGING; PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SINGLE-CELL ANALYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84869025464     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3108     Document Type: Review

References (44)

1. R. M. Caprioli, T. B. Farmer, J. Gile,. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 1997, 69, 4751-4760.
2. J. C. Jurchen, S. S. Rubakhin, J. V. Sweedler,. MALDI-MS Imaging of Features Smaller than the Size of the Laser Beam. J. Am. Soc. Mass Spectrom. 2005, 16, 1654-1659. (Pubitemid 41345157)
3. W. Bouschen, B. Spengler,. Artifacts of MALDI sample preparation investigated by high-resolution scanning microprobe matrix-assisted laser desorption/ionization (SMALDI) imaging mass spectrometry. Int. J. Mass Spectrom. 2007, 266, 129-137.
4. K. R. Tucker, E. J. Lanni, L. A. Serebryannyy, S. S. Rubakhin, J. V. Sweedler,. Stretched Tissue Mounting for MALDI Mass Spectrometry Imaging. Anal. Chem. 2011, 83, 9181-9185.
5. J. Perriere,. Recent Advances In Laser Processing of Materials, Elsevier, 2006, 472.
6. P. T. C. So,. Handbook of biomedical nonlinear optical microscopy, Oxford University Press, Toronto, 2008, p. 860.
7. A. E. Siegman,. Lasers, University Science Books, Mill Valley, Calif., 1986, 1283.
8. L. V. Vaeck, H. Struyf, W. V. Roy, F. Adams,. Organic and inorganic analysis with laser microprobe mass spectrometry. Part I: Instrumentation and methodology. Mass Spectrom. Rev. 1994, 13, 189-208. (Pubitemid 24974678)
9. J. M. Behm, J. C. Hemminger, K. R. Lykke,. Microscopic Laser Desorption/Postionization Fourier Transform Mass Spectrometry. Anal. Chem. 1996, 68, 713-719.
10. L. V. Vaeck, H. Struyf, W. V. Roy, F. Adams,. Organic and inorganic analysis with laser microprobe mass spectrometry. Part II: Applications. Mass Spectrom. Rev. 1994, 13, 209-232. (Pubitemid 24974679)
11. T. Dingle, B. W. Griffiths, J. C. Ruckman,. LIMA-a laser induced ion mass analyser. Vacuum 1981, 31, 571-577. (Pubitemid 12537144)
12. H. Vogt, H. J. Heinen, S. Meier, R. Wechsung,. LAMMA 500 principle and technical description of the instrument. Fresenius J. Anal. Chem. 1981, 308, 195-200.
13. A. Vertes, L. Balazs, R. Gijbels,. Matrix-assisted Laser Desorption of Peptides in Transmission Geometry. Rapid Commun. Mass Spectrom. 1990, 4, 263-266.
14. M. Manier, M. Reyzer, A. Goh, V. Dartois, L. Via, C. Barry, R. Caprioli,. Reagent Precoated Targets for Rapid In-Tissue Derivatization of the Anti-Tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22, 1409-1419.
15. Y. Chen, A. Vertes,. Adjustable Fragmentation in Laser Desorption/Ionization from Laser-Induced Silicon Microcolumn Arrays. Anal. Chem. 2006, 78, 5835-5844. (Pubitemid 44268981)
16. J. A. Stolee, B. N. Walker, V. Zorba, R. E. Russo, A. Vertes,. Laser-nanostructure interactions for ion production. Phys. Chem. Chem. Phys. 2012, 14, 8453-8471.
17. A. I. Zavalin, R. M. Caprioli,. Transmission Geometry Profiling / Imaging Mass Spectrometry with Sub-Cellular Resolution. 58th ASMS Conference on Mass Spectrometry and Allied Topics (Salt Lake City, UT) 2010.
18. A. I. Zavalin, R. M. Caprioli,. Transmission Geometry "Point-and-shoot" Profiling and Automatic Sub-Cellular Imaging Mass Spectrometry with 1 μm Spatial Resolution. 59th ASMS Conference on Mass Spectrometry and Allied Topics (Denver, CO) 2011.
19. A. Zavalin, J. Yang, R. M. Caprioli,. Tissue Imaging at Submicron Spatial Resolution Using Direct Transmission Geometry MALDI MS. 60th ASMS Conference on Mass Spectrometry and Allied Topics (Vancouver, BC, Canada) 2012.
20. A. L. Richards, C. B. Lietz, J. B. Wager-Miller, K. Mackie, S. Trimpin,. Imaging mass spectrometry in transmission geometry. Rapid Commun. Mass Spectrom. 2011, 25, 815-820.
21. H. Ehring, C. Costa, P. A. Demirev, B. U. R. Sundqvist,. Photochemical Versus Thermal Mechanisms in Matrix-assisted Laser Desorption/Ionization Probed by Back Side Desorption. Rapid Commun. Mass Spectrom. 1996, 10, 821-824. (Pubitemid 126680250)
22. M. Schurenberg, T. Schulz, K. Dreisewerd, F. Hillenkamp,. Matrix-assisted Laser Desorption/Ionization in Transmission Geometry: Instrumental Implementation and Mechanistic Implications. Rapid Commun. Mass Spectrom. 1996, 10, 1873-1880. (Pubitemid 27059002)
23. E. P. C. Lai, S. Owega, R. Kulczycki,. Time-of-flight mass spectrometry of bioorganic molecules by laser ablation of silver thin film substrates and particles. J. Mass Spectrom. 1998, 33, 554-564. (Pubitemid 28300266)
24. R. Knochenmuss,. Ion formation mechanisms in UV-MALDI. Analyst 2006, 131, 966-986. (Pubitemid 44313637)
25. S. Georgiou, A. Koubenakis,. Laser-Induced Material Ejection from Model Molecular Solids and Liquids: Mechanisms, Implications, and Applications. Chem. Rev. 2003, 103, 349-394.
26. B. J. Xu, R. M. Caprioli, M. E. Sanders, R. A. Jensen,. Direct analysis of laser capture microdissected cells by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. 2002, 13, 1292-1297. (Pubitemid 36875983)
27. C. N. McEwen, V. S. Pagnotti, E. D. Inutan, S. Trimpin,. New Paradigm in Ionization: Multiply Charged Ion Formation from a Solid Matrix without a Laser or Voltage. Anal. Chem. 2010, 82, 9164-9168.
28. F. Aubriet,. Laser-induced Fourier transform ion cyclotron resonance mass spectrometry of organic and inorganic compounds: methodologies and applications. Anal. Bioanal. Chem. 2007, 389, 1381-1396. (Pubitemid 350023663)
29. A. V. Zinovev, I. V. Veryovkin, J. F. Moore, M. J. Pellin,. Laser-Driven Acoustic Desorption of Organic Molecules from Back-Irradiated Solid Foils. Anal. Chem. 2007, 79, 8232-8241. (Pubitemid 350060022)
30. M. Strohalm, M. Hassman, B. Košata, M. Kodíček,. mMass data miner: an open source alternative for mass spectrometric data analysis. Rapid Commun. Mass Spectrom. 2008, 22, 905-908. (Pubitemid 351442565)
31. E. G. Bligh, W. J. Dyer,. A Rapid Method of Total Lipid Extraction and Purification. Can. J. Biochem. Physiol. 1959, 37, 911-917.
32. E. Fahy, M. Sud, D. Cotter, S. Subramaniam,. LIPID MAPS online tools for lipid research. Nucleic Acids Res. 2007, 35, W606-W612.
33. A. Thomas, J. L. Charbonneau, E. Fournaise, P. Chaurand,. Sublimation of New Matrix Candidates for High Spatial Resolution Imaging Mass Spectrometry of Lipids: Enhanced Information in Both Positive and Negative Polarities after 1,5-Diaminonapthalene Deposition. Anal. Chem. 2012, 84, 2048-2054.
34. J. A. Hankin, R. M. Barkley, R. C. Murphy,. Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging. J. Am. Soc. Mass Spectrom. 2007, 18, 1646-1652. (Pubitemid 47302327)
35. C. F. A. Culling, R. T. Allison, W. T. Bair,. Cellular Pathology Technique, Butterworth & Co., Ltd, Boston 1985, p. 98.
36. In http://www.emsdiasum.com/microscopy/technical/datasheet/19320.aspx.
37. J. Choi, D. Kim, P. J. Yoo, H. H. Lee,. Simple Detachment Patterning of Organic Layers and Its Application to Organic Light-Emitting Diodes. Adv. Mater. 2005, 17, 166-171. (Pubitemid 40242466)
38. P. D. Rawhouser, P. E. Laibinis, F. Zubair, R. M. Caprioli,. A Novel 'Reticle' Target for Calibration for MALDI Imaging Mass Spectrometry. 60th ASMS Conference on Mass Spectrometry and Allied Topics (Vancouver, BC, Canada) 2012.
39. M. Karas, M. Gluckmann, J. Schafer,. Ionization in matrix-assisted laser desorption/ionization: singly charged molecular ions are the lucky survivors. J. Mass Spectrom. 2000, 35, 1-12. (Pubitemid 30060147)
40. M. Karas, R. Kruger,. Ion Formation in MALDI: The Cluster Ionization Mechanism. Chem. Rev. 2003, 103, 427-440.
41. R. C. Murphy, J. A. Hankin, R. M. Barkley,. Imaging of lipid species by MALDI mass spectrometry. J. Lipid Res. 2009, 50 Suppl, S317-322.
42. K. Dreisewerd, R. Lemaire, G. Pohlentz, M. Salzet, M. Wisztorski, S. Berkenkamp, I. Fournier,. Molecular Profiling of Native and Matrix-Coated Tissue Slices from Rat Brain by Infrared and Ultraviolet Laser Desorption/Ionization Orthogonal Time-of-Flight Mass Spectrometry. Anal. Chem. 2007, 79, 2463-2471. (Pubitemid 46449028)
43. M. L. Zimny, W. G. Blackard,. The Surface structure of isolated pancreatic islet cells. Cell Tissue Res. 1975, 164, 467-471.
44. P. Chaurand, S. A. Schwartz, D. Billheimer, B. J. Xu, A. Crecelius, R. M. Caprioli,. Integrating Histology and Imaging Mass Spectrometry. Anal. Chem. 2004, 76, 1145-1155. (Pubitemid 38235565)