MALDI-TOF MS imaging of controlled release implants

Journal of Controlled Release

Volumn 161, Issue 1, 2012, Pages 98-108

  Kreye, F ^a,b   Hamm, G ^c   Karrout, Y ^a,b   Legouffe, R ^c   Bonnel, D ^c   Siepmann, F ^a,b   Siepmann, J ^a,b  

^a UNIV LILLE   (France)

^b France   (France)

^c ImaBiotech   (France)

Author keywords

Drug release mechanism; Extrusion; Implant; Lipid; MALDI TOF MS; Mass spectrometry imaging (MSI)

Indexed keywords

AXIAL DIRECTION; CONTROLLED RELEASE; DRUG CONCENTRATION; DRUG CONTENT; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG RELEASE KINETICS; DRUG RELEASE MECHANISM; DRUG RELEASE PATTERNS; HOT MELT; IN-VITRO; INNER STRUCTURE; LIPID MATRIX; MALDI TOF MS; MATHEMATICAL MODELING; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; MECHANICAL STRESS; MICROMETER LEVELS; ROOM TEMPERATURE; SOLID STATE TRANSFORMATIONS; SOYBEAN OIL; WATER UPTAKE;

CONTROLLED DRUG DELIVERY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG PRODUCTS; EXTRUSION; IMPLANTS (SURGICAL); LINEAR TRANSFORMATIONS; LIPIDS; MASS SPECTROMETRY; OPTICAL MICROSCOPY; STRESSES;

MOLECULAR IMAGING;

PROPRANOLOL; SOYBEAN OIL; THEOPHYLLINE; TRISTEARIN; WATER;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; COMPARATIVE STUDY; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG IMPLANT; DRUG INACTIVATION; DRUG SOLUBILITY; HYDROGENATION; IN VITRO STUDY; MATHEMATICAL MODEL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MECHANICAL STRESS; MELTING POINT; MICROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ROOM TEMPERATURE; SOLID STATE; WATER TRANSPORT;

ABSORBABLE IMPLANTS; DRUG DELIVERY SYSTEMS; MODELS, CHEMICAL; PROPRANOLOL; SOYBEAN OIL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STEARATES; THEOPHYLLINE; VASODILATOR AGENTS;

EID: 84862606788     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.04.017     Document Type: Article

References (38)

1. M. Karas, F. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons, Anal. Chem. 60 (1988) 2299-2301.
2. A.P. Kafka, T. Kleffmann, T. Rades, A. McDowell, The application of MALDI TOF MS in biopharmaceutical research, Int. J. Pharm. 417 (2011) 70-82.
3. D.H. Na, Y.S. Youn, S.D. Lee, M.W. Son, W.B. Kim, P.P. DeLuca, K.C. Lee, Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry, J. Control. Release 92 (2003) 291-299. (Pubitemid 38366152)
4. M.B. Murphy, J.D. Hartgerink, A. Goepferich, A.G. Mikos, Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties, Biomacromolecules 8 (2007) 2237-2243. (Pubitemid 47104309)
5. M. Saad, O.B. Garbuzenko, E. Ber, P. Chandna, J.J. Khandare, V.P. Pozharov, T. Minko, Receptor targeted polymers, dendrimers, liposomes: which nanocarrier is the most efficient for tumor-specific treatment and imaging? J. Control. Release 130 (2008) 107-114.
6. E. Verheyen, S. van der Wal, H. Deschout, K. Braeckmans, S. de Smedt, A. Barendregt, W.E. Hennink, C.F. van Nostrum, Protein macromonomers containing reduction-sensitive linkers for covalent immobilization and glutathione triggered release from dextran hydrogels, J. Control. Release 156 (2011) 329-336.
7. R.M. Caprioli, T.B. Farmer, J. Gile, Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS, Anal. Chem. 69 (1997) 4751-4760.
8. J. Stauber, R. Lemaire, J. Franck, D. Bonnel, D. Croix, R. Day, M.Wisztorski, I. Fournier, M. Salzet, MALDI imaging of formalin-fixed paraffin-embedded tissues: application to model animals of Parkinson disease for biomarker hunting, J. Proteome Res. 7 (2008) 969-978.
9. G. Hamm, V. Carre, A. Poutaraud, B. Maunit, G. Frache, D. Merdinoglu, J.F. Muller, Determination and imaging of metabolites from Vitis vinifera leaves by laser desorption/ionisation time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom. 24 (2010) 335-342.
10. D. Bonnel, R. Longuespee, J. Franck, M. Roudbaraki, P. Gosset, R. Day, M. Salzet, I. Fournier, Multivariate analyses for biomarkers hunting and validation through on-tissue bottom-up or in-source decay in MALDI-MSI: application to prostate cancer, Anal. Bioanal. Chem. 40 (2011) 149-165.
11. C.M. John, R.W. Odom, L. Salvati, A. Annapragada, M.Y. Fu Lu, XPS and TOF-SIMS microanalysis of a peptide/polymer drug delivery device, Anal. Chem. 67 (1995) 3871-3878.
12. A.M. Belu,M.C.Davies, J.M. Newton,N. Patel, TOF-SIMS characterization and imaging of controlled-release drug delivery systems, Anal. Chem. 72 (2000) 5625-5638.
13. L.A. Klerk, P.Y.W. Dankers, E.R. Popa, A.W. Bosman, M.E. Sanders, K.A. Reedquist, R.M.A. Heeren, TOF-secondary ion mass spectrometry imaging of polymeric scaffolds with surrounding tissue after in vivo implantation, Anal. Chem. 82 (2010) 4337-4343.
14. D. Bonnel, R. Legouffe, N. Willand, A. Baulard, G. Hamm, B. Deprez, J. Stauber, MALDI imaging techniques dedicated to drug-distribution studies, Bioanalysis 3 (2011) 1399-1406.
15. P.Y. Wang, Lipids as excipient in sustained release insulin implants, Int. J. Pharm. 54 (1989) 223-230.
16. P. Wang, Implant preparations containing bioactive macromolecule for sustained delivery, U.S. Patent 5,939,380 (1999).
17. W. Vogelhuber, E. Magni, M. Mouro, T. Spruß, C. Guse, A. Gazzaniga, A. Goepferich, Monolithic triglyceride matrices: a controlled-release system for proteins, Pharm. Dev. Technol. 8 (2003) 71-79. (Pubitemid 36337480)
18. C. Guse, S. Koennings, F. Kreye, F. Siepmann, A. Goepferich, J. Siepmann, Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms, Int. J. Pharm. 314 (2006) 137-144.
19. F. Kreye, F. Siepmann, A. Zimmer, M. Descamps, J. Siepmann, Cast lipid implants for controlled drug delivery: importance of the tempering conditions, J. Pharm. Sci. 100 (2011) 3471-3481.
20. S. Koennings, A. Sapin, T. Blunk, P. Menei, A. Goepferich, Towards controlled release of BDNF - manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain, J. Control. Release 119 (2007) 163-172. (Pubitemid 46754504)
21. S. Allababidi, J.C. Shah, Efficacy and pharmacokinetics of site-specific cefazolin delivery using biodegradable implants in the prevention of post-operative wound infections, Pharm. Res. 15 (1998) 325-333. (Pubitemid 28144248)
22. A.K. Walduck, J.P. Opdebeeck, H.E. Benson, R. Prankerd, Biodegradable implants for the delivery of veterinary vaccines: design, manufacture and antibody responses in sheep, J. Control. Release 51 (1998) 269-280. (Pubitemid 28252879)
23. C. Guse, S. Koennings, A. Maschke, M. Hacker, C. Becker, S. Schreiner, T. Blunk, T. Spruss, A. Goepferich, Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids, Int. J. Pharm. 314 (2006) 153-160.
24. F. Kreye, F. Siepmann, J. Siepmann, Lipid implants as drug delivery systems, Expert Opin. Drug Deliv. 5 (2008) 291-307. (Pubitemid 351454379)
25. M. Schwab, B. Kessler, E. Wolf, G. Jordan, S. Mohl, G. Winter, Correlation of in vivo and in vitro release data for rh-INFα lipid implants, Eur. J. Pharm. Biopharm. 70 (2008) 690-694.
26. S. Mohl, G. Winter, Continuous release of rh-interferon α-2a from triglyceride matrices, J. Control. Release 97 (2004) 67-78. (Pubitemid 38624510)
27. S. Herrmann, G. Winter, S. Mohl, F. Siepmann, J. Siepmann, Mechanisms controlling protein release from lipidic implants: effects of PEG addition, J. Control. Release 118 (2007) 161-168. (Pubitemid 46343669)
28. F. Kreye, F. Siepmann, J. Siepmann, Drug release mechanisms of compressed lipid implants, Int. J. Pharm. 404 (2011) 27-35.
29. N. Khan, D.Q.M. Craig, The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices, J. Control. Release 93 (2003) 355-368. (Pubitemid 37485957)
30. F. Kreye, F. Siepmann, A. Zimmer, M. Descamps, J. Siepmann, Controlled release implants based on cast lipid blends, Eur. J. Pharm. Sci. 43 (2011) 78-83.
31. F. Kreye, F. Siepmann, A. Zimmer, J. Siepmann, Drug release mechanisms of cast lipid implants, Eur. J. Pharm. Biopharm. 78 (2011) 394-400.
32. S. Schulze, G. Winter, Lipid extrudates as novel sustained release systems for pharmaceutical proteins, J. Control. Release 134 (2009) 177-185.
33. N. Khan, D.Q.M. Craig, Role of blooming in determining the storage stability of lipid-based dosage forms, J. Pharm. Sci. 93 (2004) 2962-2971. (Pubitemid 39657800)
34. Y.W. Choy, N. Khan, K.H. Yuen, Significance of lipid matrix aging on in vitro release and in vivo bioavailability, Int. J. Pharm. 299 (2005) 55-64. (Pubitemid 40962406)
35. M. Windbergs, C.J. Strachan, P. Kleinebudde, Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution, Eur. J. Pharm. Biopharm. 71 (2009) 80-87.
36. J.W. Hagemann, Thermal behavior and polymorphism of acylglycerides, in: N. Garti, K. Sato (Eds.), Crystallization and Polymorphism of Fats and Fatty Acids, Marcel Dekker, New York, 1988, pp. 9-97.
37. J. Vergnaud, Controlled Drug Release of Oral Dosage Forms, Ellis Horwood Limited, Chichester, 1993.
38. R. Bodmeier, H. Chen, Evaluation of biodegradable poly(lactide) pellets prepared by direct compression, J. Pharm. Sci. 78 (1989) 819-822.