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Volumn 9, Issue 2, 2009, Pages 175-185

Novel anti-tubulin cytotoxic agents for breast cancer

Author keywords

ABI 007; Breast cancer; Epothilone; Eribulin; Larotaxel; Paclitaxel poliglumex; Taxane resistance; Trastuzumab MCC DM1; Vinflunine

Indexed keywords

21 AMINOEPOTHILONE B; 9,10 DIDEHYDROEPOTHILONE D; ANTIHISTAMINIC AGENT; BEVACIZUMAB; CAPECITABINE; CISPLATIN; CORTICOSTEROID; CYTOTOXIC AGENT; DM1; DOCETAXEL; DOXORUBICIN; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; ERIBULIN; GEMCITABINE; IXABEPILONE; LAROTAXEL; MAYTANSINE; NANOPARTICLE; NAVELBINE; PACLITAXEL; PACLITAXEL POLIGLUMEX; RPR 109881A; SAGOPILONE; SORAFENIB; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN; VINCA ALKALOID; VINFLUNINE; 2 (3 AMINO 2 HYDROXYPROPYL)HEXACOSAHYDRO 3 METHOXY 26 METHYL 20,27 BIS(METHYLENE)11,15 18,21 24,28 TRIEPOXY 7,9 ETHANO 12,15 METHANO 9H,15H FURO(3,2 I)FURO(2',3' 5,6)PYRANO(4,3 B)(1,4)DIOXACYCLOPENTACOSIN 5 (4H) ONE; 2-(3-AMINO-2-HYDROXYPROPYL)HEXACOSAHYDRO-3-METHOXY-26-METHYL-20,27-BIS(METHYLENE)11,15-18,21-24,28-TRIEPOXY-7,9-ETHANO-12,15-METHANO-9H,15H-FURO(3,2-I)FURO(2',3'-5,6)PYRANO(4,3-B)(1,4)DIOXACYCLOPENTACOSIN-5-(4H)-ONE; ALBUMIN BOUND PACLITAXEL; ALBUMIN-BOUND PACLITAXEL; ALBUMINOID; ANTINEOPLASTIC AGENT; FURAN DERIVATIVE; KETONE; TAXOID; TUBULIN MODULATOR;

EID: 64349105859     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.9.2.175     Document Type: Review
Times cited : (28)

References (70)
  • 2
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H, Kellokumpu-Lehtinen PL, Bono P et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N. Engl. J. Med. 354, 809-20 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.L.2    Bono, P.3
  • 3
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353, 1673-1684 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 4
    • 33645720799 scopus 로고    scopus 로고
    • Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study
    • Presented at:, San Antonio, TX, USA, 8-11 December, Abstract 1
    • Slamon D, Eiermann W, Robert N et al. Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (ACT) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (ACTH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study. Presented at: 28th San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 8-11 December 2005 (Abstract 1).
    • (2005) 28th San Antonio Breast Cancer Symposium
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 5
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 6
    • 54549100206 scopus 로고    scopus 로고
    • Atzori F, Fornier M. Epothilones in breast cancer: current status and future directions. Expert Rev. Anticancer Ther. 8(8), 1299-1311 (2008).
    • Atzori F, Fornier M. Epothilones in breast cancer: current status and future directions. Expert Rev. Anticancer Ther. 8(8), 1299-1311 (2008).
  • 7
    • 0030018666 scopus 로고    scopus 로고
    • Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
    • Gerth K, Bedorf N, Hofle G et al. Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J. Antibiot. (Tokyo) 4(9), 560-563 (1996).
    • (1996) J. Antibiot. (Tokyo) , vol.4 , Issue.9 , pp. 560-563
    • Gerth, K.1    Bedorf, N.2    Hofle, G.3
  • 8
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on α,β-tubulin by electron crystallography
    • Nettles JH, Li H, Cornett B et al. The binding mode of epothilone A on α,β-tubulin by electron crystallography. Science 30(5), 866-869 (2004).
    • (2004) Science , vol.30 , Issue.5 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3
  • 9
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • Thomas ES, Gomez HL, Li RK et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J. Clin. Oncol. 2(5), 5210-5217 (2007).
    • (2007) J. Clin. Oncol , vol.2 , Issue.5 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3
  • 10
    • 32944481043 scopus 로고    scopus 로고
    • Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies
    • Nyman DW, Campbell KJ, Hersh E et al. Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies. J. Clin. Oncol. 2(3), 7785-7793 (2005).
    • (2005) J. Clin. Oncol , vol.2 , Issue.3 , pp. 7785-7793
    • Nyman, D.W.1    Campbell, K.J.2    Hersh, E.3
  • 11
    • 33644753906 scopus 로고    scopus 로고
    • Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with Cremophor-based paclitaxel
    • Desai N, Trieu V, Yao Z et al. Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with Cremophor-based paclitaxel. Clin. Cancer Res. 1(2), 1317-1324 (2006).
    • (2006) Clin. Cancer Res , vol.1 , Issue.2 , pp. 1317-1324
    • Desai, N.1    Trieu, V.2    Yao, Z.3
  • 12
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilised, nanoparticle formulation of paclitaxel
    • Ibrahim NK, Desai N, Legha S et al. Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilised, nanoparticle formulation of paclitaxel. Clin. Cancer Res. 8, 1038-1044 (2002).
    • (2002) Clin. Cancer Res , vol.8 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3
  • 13
    • 24944505659 scopus 로고    scopus 로고
    • Multicenter Phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer
    • Ibrahim NK, Samuels B, Page R et al. Multicenter Phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer. J. Clin. Oncol. 2(3), 6019-6026 (2005).
    • (2005) J. Clin. Oncol , vol.2 , Issue.3 , pp. 6019-6026
    • Ibrahim, N.K.1    Samuels, B.2    Page, R.3
  • 14
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar WJ, Tjulandin S, Davidson N et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J. Clin. Oncol. 2(3), 7794-803 (2005).
    • (2005) J. Clin. Oncol , vol.2 , Issue.3 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 15
    • 34548453947 scopus 로고    scopus 로고
    • Randomized comparison of weekly or every-3-week (q3w) nab-paclitaxel compared with q3w docetaxel as first-line therapy in patients with metastatic breast cancer
    • Abstract 1032
    • Gradishar W, Krasnojon D, Cheporov S et al. Randomized comparison of weekly or every-3-week (q3w) nab-paclitaxel compared with q3w docetaxel as first-line therapy in patients with metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 25(Suppl. 8), (2007) (Abstract 1032).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25 , Issue.SUPPL. 8
    • Gradishar, W.1    Krasnojon, D.2    Cheporov, S.3
  • 16
    • 50549096593 scopus 로고    scopus 로고
    • Gemcitabine plus paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
    • Albain KS, Nag SM, Calderillo-Ruiz G et al. Gemcitabine plus paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment. J. Clin. Oncol. 2(6), 3950-3957 (2008).
    • (2008) J. Clin. Oncol , vol.2 , Issue.6 , pp. 3950-3957
    • Albain, K.S.1    Nag, S.M.2    Calderillo-Ruiz, G.3
  • 17
    • 42649120517 scopus 로고    scopus 로고
    • NCCTG Phase II trial N0531of weekly nab-paclitaxel in combination with gemcitabine in patients with metastatic breast cancer
    • Abstract 1048
    • Roy V, LaPlant B, Gross G et al. NCCTG Phase II trial N0531of weekly nab-paclitaxel in combination with gemcitabine in patients with metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 25, (2007) (Abstract 1048).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25
    • Roy, V.1    LaPlant, B.2    Gross, G.3
  • 18
    • 77950539733 scopus 로고    scopus 로고
    • Phase II study of weekly nanoparticle albumin bound (nab)paclitaxel with carboplatin and trastuzumab as 1st-line therapy for HER2-positive metastatic breast cancer (MBC)
    • Abstract 1047
    • Seidman A, Conlin A, Bach A et al. Phase II study of weekly nanoparticle albumin bound (nab)paclitaxel with carboplatin and trastuzumab as 1st-line therapy for HER2-positive metastatic breast cancer (MBC). ASCO Meeting Abstracts 26, (2008) (Abstract 1047).
    • (2008) ASCO Meeting Abstracts , vol.26
    • Seidman, A.1    Conlin, A.2    Bach, A.3
  • 19
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 35(7), 2666-2676 (2007).
    • (2007) N. Engl. J. Med , vol.35 , Issue.7 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 20
    • 65749095083 scopus 로고    scopus 로고
    • Miles D, Chan A, Romieu G. Randomized, double-blind, placebo-controlled, Phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. J. Clin. Oncol. ASCO Ann. Meeting Proc. 26, LBA1011 (2008).
    • Miles D, Chan A, Romieu G. Randomized, double-blind, placebo-controlled, Phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. J. Clin. Oncol. ASCO Ann. Meeting Proc. 26, LBA1011 (2008).
  • 21
    • 43249115659 scopus 로고    scopus 로고
    • Randomized Phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: Final results of Cancer and Leukemia Group B protocol 9840
    • Seidman AD, Berry D, Cirrincione C et al. Randomized Phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840. J. Clin. Oncol. 2(6), 1642-1649 (2008).
    • (2008) J. Clin. Oncol , vol.2 , Issue.6 , pp. 1642-1649
    • Seidman, A.D.1    Berry, D.2    Cirrincione, C.3
  • 22
    • 0037687355 scopus 로고    scopus 로고
    • Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
    • Citron ML, Berry DA, Cirrincione C et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J. Clin. Oncol. 2(1), 1431-1439 (2003).
    • (2003) J. Clin. Oncol , vol.2 , Issue.1 , pp. 1431-1439
    • Citron, M.L.1    Berry, D.A.2    Cirrincione, C.3
  • 23
    • 65749099492 scopus 로고    scopus 로고
    • Khan M, Sharef S, Amato R. Phase II study of xyotax (PPX) for androgen independent prostate cancer Proc. Am. Soc. Clin. Oncol. 24, (2006) (Abstract 14624).
    • Khan M, Sharef S, Amato R. Phase II study of xyotax (PPX) for androgen independent prostate cancer Proc. Am. Soc. Clin. Oncol. 24, (2006) (Abstract 14624).
  • 24
    • 24644471290 scopus 로고    scopus 로고
    • Paclitaxel poliglumex in combination with carboplatin for the first-line treatment of patients with advanced non-small cell lung cancer: Preliminary data
    • Abstract 7230
    • Nemunaitis J, Leighl N, Miller W et al. Paclitaxel poliglumex in combination with carboplatin for the first-line treatment of patients with advanced non-small cell lung cancer: preliminary data. Proc. Am. Soc. Clin. Oncol. 23, (2005) (Abstract 7230).
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.23
    • Nemunaitis, J.1    Leighl, N.2    Miller, W.3
  • 25
    • 12744278961 scopus 로고    scopus 로고
    • Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
    • Sabbatini P, Aghajanian C, Dizon D et al. Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. J. Clin. Oncol. 2(2), 4523-4531 (2004).
    • (2004) J. Clin. Oncol , vol.2 , Issue.2 , pp. 4523-4531
    • Sabbatini, P.1    Aghajanian, C.2    Dizon, D.3
  • 26
    • 34250612643 scopus 로고    scopus 로고
    • Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: Unexpected incidence of hypersensitivity reactions
    • Lin NU, Parker LM, Come SE et al. Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: unexpected incidence of hypersensitivity reactions. Invest. New Drugs 2(5), 369-375 (2007).
    • (2007) Invest. New Drugs , vol.2 , Issue.5 , pp. 369-375
    • Lin, N.U.1    Parker, L.M.2    Come, S.E.3
  • 27
    • 65749091746 scopus 로고    scopus 로고
    • Phase II trial of paclitaxel polyglumex with capecitabine for metastatic breast cancer
    • Abstract 1063
    • Northfelt D, Allred J, Liu H et al. Phase II trial of paclitaxel polyglumex with capecitabine for metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 1063).
    • (2008) Proc. Am. Soc. Clin. Oncol , vol.26
    • Northfelt, D.1    Allred, J.2    Liu, H.3
  • 28
    • 0034857136 scopus 로고    scopus 로고
    • Preclinical evaluation of new taxoids
    • Bissery MC: Preclinical evaluation of new taxoids. Curr. Pharm. Des. 7, 1251-1257 (2001).
    • (2001) Curr. Pharm. Des , vol.7 , pp. 1251-1257
    • Bissery, M.C.1
  • 30
    • 65749089534 scopus 로고    scopus 로고
    • In vivo synergy between doxorubicin, cisplatin or vinorelbine and RPR 109881A, a new taxoid
    • Abstract 3414
    • Vrignaud P, Lejeune P, Bissery M-C. In vivo synergy between doxorubicin, cisplatin or vinorelbine and RPR 109881A, a new taxoid. Proc. Am. Assoc. Cancer Res. 46, (2005) (Abstract 3414).
    • (2005) Proc. Am. Assoc. Cancer Res , vol.46
    • Vrignaud, P.1    Lejeune, P.2    Bissery, M.-C.3
  • 31
    • 0033863452 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of a new taxoid, RPR 109881A, given as a 1-hour intravenous infusion in patients with advanced solid tumors
    • Kurata T, Shimada Y, Tamura T et al. Phase I and pharmacokinetic study of a new taxoid, RPR 109881A, given as a 1-hour intravenous infusion in patients with advanced solid tumors. J. Clin. Oncol. 1(8), 3164-3171 (2000).
    • (2000) J. Clin. Oncol , vol.1 , Issue.8 , pp. 3164-3171
    • Kurata, T.1    Shimada, Y.2    Tamura, T.3
  • 32
    • 0035990845 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic studies of the taxoid derivative RPR 109881A administered as a 1-hour or a 3-hour infusion in patients with advanced solid tumors
    • Sessa C, Cuvier C, Caldiera S et al. Phase I clinical and pharmacokinetic studies of the taxoid derivative RPR 109881A administered as a 1-hour or a 3-hour infusion in patients with advanced solid tumors. Ann. Oncol. 1(3), 1140-1150 (2002).
    • (2002) Ann. Oncol , vol.1 , Issue.3 , pp. 1140-1150
    • Sessa, C.1    Cuvier, C.2    Caldiera, S.3
  • 33
    • 0034671296 scopus 로고    scopus 로고
    • Phase I dose-finding study of a new taxane, RPR 109881A, administered as a one-hour intravenous infusion days 1 and 8 to patients with advanced solid tumors
    • Gelmon KA, Latreille J, Tolcher A et al. Phase I dose-finding study of a new taxane, RPR 109881A, administered as a one-hour intravenous infusion days 1 and 8 to patients with advanced solid tumors. J. Clin. Oncol. 1 8, 4098-108 (2000).
    • (2000) J. Clin. Oncol , vol.1 , Issue.8 , pp. 4098-4108
    • Gelmon, K.A.1    Latreille, J.2    Tolcher, A.3
  • 34
    • 46249085475 scopus 로고    scopus 로고
    • Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy
    • Dieras V, Limentani S, Romieu G et al. Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. Ann. Oncol. 1(9), 1255-1260 (2008).
    • (2008) Ann. Oncol , vol.1 , Issue.9 , pp. 1255-1260
    • Dieras, V.1    Limentani, S.2    Romieu, G.3
  • 35
    • 65749091544 scopus 로고    scopus 로고
    • In vivo synergy between trastuzumab (Herceptin®) and larotaxel (RPR 109881A), a new taxoid
    • Abstract 1432
    • Vrignaud P, Chiron M, Stackhouse M et al. In vivo synergy between trastuzumab (Herceptin®) and larotaxel (RPR 109881A), a new taxoid. Proc. Am. Assoc. Cancer Res. (2007) (Abstract 1432).
    • (2007) Proc. Am. Assoc. Cancer Res
    • Vrignaud, P.1    Chiron, M.2    Stackhouse, M.3
  • 36
    • 58149140537 scopus 로고    scopus 로고
    • Randomized multicenter Phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancer
    • Zatloukal P, Gervais R, Vansteenkiste J et al. Randomized multicenter Phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancer. J. Thorac. Oncol. 3, 894-901 (2008).
    • (2008) J. Thorac. Oncol , vol.3 , pp. 894-901
    • Zatloukal, P.1    Gervais, R.2    Vansteenkiste, J.3
  • 37
    • 0031820395 scopus 로고    scopus 로고
    • Vinflunine (20é, 20é-difluoro-3é, 4é-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro
    • Etievant C, Barret JM, Kruczynski A et al. Vinflunine (20é, 20é-difluoro-3é, 4é-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. Invest. New Drugs 1(6), 3-17 (1998).
    • (1998) Invest. New Drugs , vol.1 , Issue.6 , pp. 3-17
    • Etievant, C.1    Barret, J.M.2    Kruczynski, A.3
  • 38
    • 0034918410 scopus 로고    scopus 로고
    • Markedly diminished drug resistanceinducing properties of vinflunine (20′, 20′-difluoro-3′, 4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumor cells in vivo and in vitro
    • Etievant C, Kruczynski A, Barret JM et al. Markedly diminished drug resistanceinducing properties of vinflunine (20′, 20′-difluoro-3′, 4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumor cells in vivo and in vitro. Cancer Chemother. Pharmacol. 4(8), 62-70 (2001).
    • (2001) Cancer Chemother. Pharmacol , vol.4 , Issue.8 , pp. 62-70
    • Etievant, C.1    Kruczynski, A.2    Barret, J.M.3
  • 39
    • 0031780236 scopus 로고    scopus 로고
    • A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity
    • Lobert S, Ingram JW, Hill BT et al. A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity. Mol. Pharmacol. 5(3), 908-915 (1998).
    • (1998) Mol. Pharmacol , vol.5 , Issue.3 , pp. 908-915
    • Lobert, S.1    Ingram, J.W.2    Hill, B.T.3
  • 40
    • 0031912695 scopus 로고    scopus 로고
    • Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated vinca alkaloid
    • Kruczynski A, Colpaert F, Tarayre JP et al. Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated vinca alkaloid. Cancer Chemother. Pharmacol. 4(1), 437-447 (1998).
    • (1998) Cancer Chemother. Pharmacol , vol.4 , Issue.1 , pp. 437-447
    • Kruczynski, A.1    Colpaert, F.2    Tarayre, J.P.3
  • 41
    • 0037819331 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumors
    • Bennouna J, Fumoleau P, Armand JP et al. Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumors. Ann. Oncol. 1(4), 630-637 (2003).
    • (2003) Ann. Oncol , vol.1 , Issue.4 , pp. 630-637
    • Bennouna, J.1    Fumoleau, P.2    Armand, J.P.3
  • 42
    • 33646681175 scopus 로고    scopus 로고
    • Phase I study of vinflunine administered as a 10-min infusion on days 1 and 8 every 3 weeks
    • Johnson P, Geldart T, Fumoleau P et al. Phase I study of vinflunine administered as a 10-min infusion on days 1 and 8 every 3 weeks. Invest. New Drugs 2(4), 223-231 (2006).
    • (2006) Invest. New Drugs , vol.2 , Issue.4 , pp. 223-231
    • Johnson, P.1    Geldart, T.2    Fumoleau, P.3
  • 43
    • 33646844469 scopus 로고    scopus 로고
    • A Phase II study of vinflunine in bladder cancer patients progressing after first-line platinum-containing regimen
    • Culine S, Theodore C, De Santis M et al. A Phase II study of vinflunine in bladder cancer patients progressing after first-line platinum-containing regimen. Br. J. Cancer 9(4), 1395-1401 (2006).
    • (2006) Br. J. Cancer , vol.9 , Issue.4 , pp. 1395-1401
    • Culine, S.1    Theodore, C.2    De Santis, M.3
  • 44
    • 33646831647 scopus 로고    scopus 로고
    • Vinflunine - an active chemotherapy for treatment of advanced non-small-cell lung cancer previously treated with a platinum-based regimen: Results of a Phase II study
    • Bennouna J, Breton JL, Tourani JM et al. Vinflunine - an active chemotherapy for treatment of advanced non-small-cell lung cancer previously treated with a platinum-based regimen: results of a Phase II study. Br. J. Cancer 9(4), 1383-1388 (2006).
    • (2006) Br. J. Cancer , vol.9 , Issue.4 , pp. 1383-1388
    • Bennouna, J.1    Breton, J.L.2    Tourani, J.M.3
  • 45
    • 36048996561 scopus 로고    scopus 로고
    • Phase II study of vinflunine in malignant pleural mesothelioma
    • Talbot DC, Margery J, Dabouis G et al. Phase II study of vinflunine in malignant pleural mesothelioma. J. Clin. Oncol. 2(5), 4751-4756 (2007).
    • (2007) J. Clin. Oncol , vol.2 , Issue.5 , pp. 4751-4756
    • Talbot, D.C.1    Margery, J.2    Dabouis, G.3
  • 46
    • 33745042184 scopus 로고    scopus 로고
    • Phase II study of vinflunine in patients with metastatic renal cell carcinoma
    • Goldstein D, Ackland SP, Bell DR et al. Phase II study of vinflunine in patients with metastatic renal cell carcinoma. Invest. New Drugs 2(4), 429-434 (2006).
    • (2006) Invest. New Drugs , vol.2 , Issue.4 , pp. 429-434
    • Goldstein, D.1    Ackland, S.P.2    Bell, D.R.3
  • 47
    • 34547838224 scopus 로고    scopus 로고
    • Phase II study of IV vinflunine in patients with chemotherapy naive metastatic malignant melanoma
    • Olver IN, Byrne MJ, Walpole E et al. Phase II study of IV vinflunine in patients with chemotherapy naive metastatic malignant melanoma. Eur. J. Cancer 4(3), 1829-1832 (2007).
    • (2007) Eur. J. Cancer , vol.4 , Issue.3 , pp. 1829-1832
    • Olver, I.N.1    Byrne, M.J.2    Walpole, E.3
  • 48
    • 33750457974 scopus 로고    scopus 로고
    • Vinflunine: A new active drug for second-line treatment of advanced breast cancer. Results of a Phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy
    • Campone M, Cortes-Funes H, Vorobiof D et al. Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a Phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy. Br. J. Cancer 9(5), 1161-1166 (2006).
    • (2006) Br. J. Cancer , vol.9 , Issue.5 , pp. 1161-1166
    • Campone, M.1    Cortes-Funes, H.2    Vorobiof, D.3
  • 49
    • 65749103118 scopus 로고    scopus 로고
    • A dose-finding and pharmacokinetic study of I.V. vinflunine in combination with capecitabine as second line treatment of metastatic breast cancer
    • Presented at:, San Antonio, TX, USA, 14-17 December, Abstract 6069
    • Campone M, Fumoleau P, Roche H et al. A dose-finding and pharmacokinetic study of I.V. vinflunine in combination with capecitabine as second line treatment of metastatic breast cancer. Presented at: 29th San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 14-17 December 2006 (Abstract 6069).
    • (2006) 29th San Antonio Breast Cancer Symposium
    • Campone, M.1    Fumoleau, P.2    Roche, H.3
  • 50
    • 41549161700 scopus 로고    scopus 로고
    • Vinflunine in combination with trastuzumab for treatment of HER2-positive metastatic breast cancer
    • Abstract 1058
    • Paridaens R, Wildiers H, Dalenc F et al. Vinflunine in combination with trastuzumab for treatment of HER2-positive metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 25, (2007) (Abstract 1058).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25
    • Paridaens, R.1    Wildiers, H.2    Dalenc, F.3
  • 51
    • 45349093860 scopus 로고    scopus 로고
    • Preliminary results of a multicenter Phase II trial of vinflunine (with trastuzumab in HER2+ pts) as first-line treatment in metastatic breast cancer
    • Abstract 1043
    • Peacock N, Spigel D, Mainwaring M et al. Preliminary results of a multicenter Phase II trial of vinflunine (with trastuzumab in HER2+ pts) as first-line treatment in metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 25, (2007) (Abstract 1043).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25
    • Peacock, N.1    Spigel, D.2    Mainwaring, M.3
  • 52
    • 23144433687 scopus 로고    scopus 로고
    • The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    • Jordan MA, Kamath K, Manna T et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol. Cancer Ther. 4, 1086-1095 (2005).
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1086-1095
    • Jordan, M.A.1    Kamath, K.2    Manna, T.3
  • 53
    • 58149347705 scopus 로고    scopus 로고
    • Microtubule active agents: Beyond the taxane frontier
    • Morris PG, Fornier MN. Microtubule active agents: beyond the taxane frontier. Clin. Cancer Res. 1(4), 7167-7172 (2008).
    • (2008) Clin. Cancer Res , vol.1 , Issue.4 , pp. 7167-7172
    • Morris, P.G.1    Fornier, M.N.2
  • 54
    • 4143052665 scopus 로고    scopus 로고
    • Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389
    • Kuznetsov G, Towle MJ, Cheng H et al. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. Cancer Res. 6(4), 5760-5766 (2004).
    • (2004) Cancer Res , vol.6 , Issue.4 , pp. 5760-5766
    • Kuznetsov, G.1    Towle, M.J.2    Cheng, H.3
  • 55
    • 0035110756 scopus 로고    scopus 로고
    • In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B
    • Towle MJ, Salvato KA, Budrow J et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 6(1), 1013-1021 (2001).
    • (2001) Cancer Res , vol.6 , Issue.1 , pp. 1013-1021
    • Towle, M.J.1    Salvato, K.A.2    Budrow, J.3
  • 56
    • 65749116708 scopus 로고    scopus 로고
    • Desai K, Goel S, Mita A et al. Dose escalation and pharmacokinetic study of E 7389, a microtubule-binding drug in patients with advanced solid tumors Proc. Am. Soc. Clin. Oncol. 23, (2005) (Abstract 3090).
    • Desai K, Goel S, Mita A et al. Dose escalation and pharmacokinetic study of E 7389, a microtubule-binding drug in patients with advanced solid tumors Proc. Am. Soc. Clin. Oncol. 23, (2005) (Abstract 3090).
  • 57
    • 33745000162 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial
    • Abstract 3036
    • Synold T, Morgan R, Newman E et al. A Phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial. Proc. Am. Soc. Clin. Oncol. 16, (2005) (Abstract 3036).
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.16
    • Synold, T.1    Morgan, R.2    Newman, E.3
  • 58
    • 65749092811 scopus 로고    scopus 로고
    • Rubin E, Rosen L, Rajeev V et al. Phase I study of E7389 administered by 1 hour infusion every 21 days Proc. Am. Soc. Clin. Oncol. 23, (2005) (Abstract 2054).
    • Rubin E, Rosen L, Rajeev V et al. Phase I study of E7389 administered by 1 hour infusion every 21 days Proc. Am. Soc. Clin. Oncol. 23, (2005) (Abstract 2054).
  • 59
    • 65749092156 scopus 로고    scopus 로고
    • Phase II study of eribulin mesylate (E7389) in patients with locally advanced or metastatic breast cancer previously treated with anthracycline, taxane, and capecitabine therapy
    • Abstract 1084
    • Vahdat L, Twelves C, Allison M et al. Phase II study of eribulin mesylate (E7389) in patients with locally advanced or metastatic breast cancer previously treated with anthracycline, taxane, and capecitabine therapy. Proc. Am. Soc. Clin. Oncol. 15S, (2008) (Abstract 1084).
    • (2008) Proc. Am. Soc. Clin. Oncol
    • Vahdat, L.1    Twelves, C.2    Allison, M.3
  • 60
    • 65749090719 scopus 로고    scopus 로고
    • Beeram M, A. Burris H, Modi S et al. A Phase I study of trastuzumab-DM1 (T-DM1), a first-in-class HER2 antibodydrug conjugate (ADC), in patients (pts) with advanced HER2+ breast cancer (BC). ASCO Meeting Abstracts (2008) (Abstract 1028).
    • Beeram M, A. Burris H, Modi S et al. A Phase I study of trastuzumab-DM1 (T-DM1), a first-in-class HER2 antibodydrug conjugate (ADC), in patients (pts) with advanced HER2+ breast cancer (BC). ASCO Meeting Abstracts (2008) (Abstract 1028).
  • 61
    • 65749083788 scopus 로고    scopus 로고
    • A Phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients (pts) with advanced HER2+ breast cancer (BC)
    • Abstract 1029
    • Holden S, Beeram M, Krop I et al. A Phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients (pts) with advanced HER2+ breast cancer (BC). ASCO Meeting Abstracts (2008) (Abstract 1029).
    • (2008) ASCO Meeting Abstracts
    • Holden, S.1    Beeram, M.2    Krop, I.3
  • 63
    • 36348995099 scopus 로고    scopus 로고
    • Randomized Phase II trial of three dosing schedules of nanoparticle albumin-bound paclitaxel with bevacizumab as first-line therapy for HER2-negative metastatic breast cancer: An initial interim safety report
    • Abstract 1104
    • Conlin A, Seidman A, Moynahan M et al. Randomized Phase II trial of three dosing schedules of nanoparticle albumin-bound paclitaxel with bevacizumab as first-line therapy for HER2-negative metastatic breast cancer: an initial interim safety report. ASCO Meeting Abstracts 25, (2007) (Abstract 1104).
    • (2007) ASCO Meeting Abstracts , vol.25
    • Conlin, A.1    Seidman, A.2    Moynahan, M.3
  • 64
    • 65749085985 scopus 로고    scopus 로고
    • Phase II study of nab-paclitaxel, bevacizumab, and gemcitabine for first-line therapy of patients with HER2-negative metastatic breast cancer
    • Abstract 1089
    • Gluck S, Lobo C, Reis I et al. Phase II study of nab-paclitaxel, bevacizumab, and gemcitabine for first-line therapy of patients with HER2-negative metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 1089).
    • (2008) Proc. Am. Soc. Clin. Oncol , vol.26
    • Gluck, S.1    Lobo, C.2    Reis, I.3
  • 65
    • 65749095629 scopus 로고    scopus 로고
    • Phase II trial of weekly nab-paclitaxel in combination with bevacizumab as first-line treatment in metastatic breast cancer
    • Abstract 1075
    • Danso M, Blum J, Robert N et al. Phase II trial of weekly nab-paclitaxel in combination with bevacizumab as first-line treatment in metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 1075).
    • (2008) Proc. Am. Soc. Clin. Oncol , vol.26
    • Danso, M.1    Blum, J.2    Robert, N.3
  • 66
    • 42549136502 scopus 로고    scopus 로고
    • Dose-dense nab-paclitaxel (nanoparticle albumin-bound paclitaxel) in adjuvant chemotherapy for breast cancer: A feasibility study
    • Abstract 594
    • Burstein H, Mayer E, Peppercorn J et al. Dose-dense nab-paclitaxel (nanoparticle albumin-bound paclitaxel) in adjuvant chemotherapy for breast cancer: a feasibility study. Proc. Am. Soc. Clin. Oncol. 25, (2007) (Abstract 594).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25
    • Burstein, H.1    Mayer, E.2    Peppercorn, J.3
  • 67
    • 50949110987 scopus 로고    scopus 로고
    • Cardiac safety of adjuvant bevacizumab plus dose-dense doxorubicin/cyclophosphamide followed by nanoparticle albumin-bound paclitaxel in patients with early stage breast cancer
    • Presented December, Abstract 3065
    • McArthur H, Rugo H, Paulson M et al. Cardiac safety of adjuvant bevacizumab plus dose-dense doxorubicin/cyclophosphamide followed by nanoparticle albumin-bound paclitaxel in patients with early stage breast cancer. Presented as: San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 13-16 December 2007 (Abstract 3065).
    • (2007) as: San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 13-16
    • McArthur, H.1    Rugo, H.2    Paulson, M.3
  • 68
    • 65749106270 scopus 로고    scopus 로고
    • Morris P, Dickler M, McArthur H et al. Dose-dense doxorubicin-cyclophosphamide X 4 and short-term changes in left ventricular ejection fraction alone or with bevacizumab in patients with early stage breast cancer Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 637).
    • Morris P, Dickler M, McArthur H et al. Dose-dense doxorubicin-cyclophosphamide X 4 and short-term changes in left ventricular ejection fraction alone or with bevacizumab in patients with early stage breast cancer Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 637).
  • 69
    • 65749113074 scopus 로고    scopus 로고
    • Incidence and severity of sensory neuropathy with bevacizumab added to dose-dense doxorubicin/ cyclophosphamide followed by nanoparticle albumin-bound paclitaxel in patients with early stage breast cancer
    • Abstract 589
    • Sierecki M, Rugo H, McArthur H et al. Incidence and severity of sensory neuropathy with bevacizumab added to dose-dense doxorubicin/ cyclophosphamide followed by nanoparticle albumin-bound paclitaxel in patients with early stage breast cancer. Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 589).
    • (2008) Proc. Am. Soc. Clin. Oncol , vol.26
    • Sierecki, M.1    Rugo, H.2    McArthur, H.3
  • 70
    • 65749086581 scopus 로고    scopus 로고
    • Larotaxel in combination with trastuzumab in patients with HER2 + metastatic breast cancer: Interim analysis of an open Phase II label study
    • Abstract 1070
    • Dieras V, Viens P, Veyret C et al. Larotaxel in combination with trastuzumab in patients with HER2 + metastatic breast cancer: interim analysis of an open Phase II label study. Proc. Am. Soc. Clin. Oncol. 26, (2008) (Abstract 1070).
    • (2008) Proc. Am. Soc. Clin. Oncol , vol.26
    • Dieras, V.1    Viens, P.2    Veyret, C.3


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