C/EBPΑ is required for development of dendritic cell progenitors

Blood

Volumn 121, Issue 20, 2013, Pages 4073-4081

  Welner, Robert S ^a   Bararia, Deepak ^a   Amabile, Giovanni ^a   Czibere, Akos ^a   Benoukraf, Touati ^b   Bach, Christian ^a   Wansa, K Disnika Senali Abayratna ^b   Ye, Min ^a   Zhang, Hong ^a   Iino, Tadafumi ^c   Hetherington, Christopher J ^a   Akashi, Koichi ^c   Tenen, Daniel G ^a,b  

^a HARVARD STEM CELL INSTITUTE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; GENE CONTROL; GENE EXPRESSION; LYMPHOID TISSUE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; STEM CELL; ANIMAL; CELL CULTURE; CLUSTER ANALYSIS; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE SILENCING; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELLS, CULTURED; CLUSTER ANALYSIS; DENDRITIC CELLS; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; LYMPHOID TISSUE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STEM CELLS;

MLCS; MLOWN;

EID: 84880987215     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-10-463448     Document Type: Article

References (49)

1. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010; 327(5966):656-661.
2. Geissmann F. The origin of dendritic cells. Nat Immunol. 2007;8(6):558-560.
3. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669-692.
4. Liu K, Waskow C, Liu X, Yao K, Hoh J, Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol. 2007;8(6):578-583.
5. Fogg DK, Sibon C, Miled C, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science. 2006;311(5757):83-87.
6. Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG. Identification of clonogenic common Flt31M-CSFR1 plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007;8(11):1207-1216.
7. Naik SH, Sathe P, Park HY, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol. 2007;8(11): 1217-1226.
8. Ishikawa F, Niiro H, Iino T, et al. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood. 2007;110(10): 3591-3660.
9. Liu K, Victora GD, Schwickert TA, et al. In vivo analysis of dendritic cell development and homeostasis. Science. 2009;324(5925):392-397.
10. Rosenbauer F, Koschmieder S, Steidl U, Tenen DG. Effect of transcription-factor concentrations on leukemic stem cells. Blood. 2005;106(5): 1519-1524.
11. Hume DA. Macrophages as APC and the dendritic cell myth. J Immunol. 2008;181(9): 5829-5835.
12. Shigematsu H, Reizis B, Iwasaki H, et al. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 2004;21(1):43-53.
13. Carotta S, Dakic A, D’Amico A, et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity. 2010;32(5):628-641.
14. Wu L, Liu YJ. Development of dendritic-cell lineages. Immunity. 2007;26(6):741-750.
15. Ginhoux F, Liu K, Helft J, et al. The origin and development of nonlymphoid tissue CD1031 DCs. J Exp Med. 2009;206(13):3115-3130.
16. Miller JC, Brown BD, Shay T, et al; Immunological Genome Consortium. Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol. 2012;13(9):888-899.
17. D’Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med. 2003; 198(2):293-303.
18. Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. Flt3 ligand regulates dendritic cell development from Flt31 lymphoid and myeloid-committed progenitors to Flt31 dendritic cells in vivo. J Exp Med. 2003;198(2):305-313.
19. Wölfler A, Danen-van Oorschot AA, Haanstra JR, et al. Lineage-instructive function of C/EBPa in multipotent hematopoietic cells and early thymic progenitors. Blood. 2010;116(20):4116-4125.
20. Welner RS, Pelayo R, Nagai Y, et al. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood. 2008;112(9):3753-3761.
21. Merad M, Manz MG. Dendritic cell homeostasis. Blood. 2009;113(15):3418-3427.
22. Wang H, Lee CH, Qi C, et al. IRF8 regulates B-cell lineage specification, commitment, and differentiation. Blood. 2008;112(10):4028-4038.
23. Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity. 2010; 33(6):905-916.
24. Birkenmeier EH, Gwynn B, Howard S, et al. Tissue-specific expression, developmental regulation and genetic mapping of the gene encoding C/EBP. Genes Dev. 1989;3(8): 1146-1156.
25. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG. A novel human CCAAT/ enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Genomics. 1996;35(1):30-38.
26. Rosenbauer F, Tenen DG. Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol. 2007;7(2): 105-117.
27. Hirai H, Zhang P, Dayaram T, et al. C/EBPbeta is required for ‘emergency’ granulopoiesis. Nat Immunol. 2006;7(7):732-739.
28. Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004;21(6):853-863.
29. Friedman AD. Transcriptional control of granulocyte and monocyte development. Oncogene. 2007;26(47):6816-6828.
30. Iwasaki H, Somoza C, Shigematsu H, et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005;106(5):1590-1600.
31. Caton ML, Smith-Raska MR, Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007;204(7):1653-1664.
32. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA. 2001;98(1):31-36.
33. Pan YF, Wansa KD, Liu MH, et al. Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. J Biol Chem. 2008;283(47): 32977-32988.
34. Zhang Z, Chang CW, Goh WL, Sung WK, Cheung E. CENTDIST: discovery of co-associated factors by motif distribution. Nucleic Acids Res. 2011; 39(Web Server issue):W391-W399.
35. Portales-Casamar E, Thongjuea S, Kwon AT, et al. JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res. 2010;38(Database issue):D105-D110.
36. Xu Y, Zhan Y, Lew AM, Naik SH, Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol. 2007; 179(11):7577-7584.
37. Ye M, Zhang H, Amabile G, et al. C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence. Nat Cell Biol. 2013;15(4):385-394.
38. Sathe P, Vremec D, Wu L, Corcoran L, Shortman K. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood. 2012;121(1):11-19.
39. Schmid MA, Kingston D, Boddupalli S, Manz MG. Instructive cytokine signals in dendritic cell lineage commitment. Immunol Rev. 2010;234(1): 32-44.
40. Watowich SS, Liu YJ. Mechanisms regulating dendritic cell specification and development. Immunol Rev. 2010;238(1):76-92.
41. Meredith MM, Liu K, Darrasse-Jeze G, et al. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med. 2012;209(6): 1153-1165.
42. Meredith MM, Liu K, Kamphorst AO, et al. Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med. 2012;209(9):1583-1593.
43. Iwama A, Osawa M, Hirasawa R, et al. Reciprocal roles for CCAAT/enhancer binding protein (C/ EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med. 2002; 195(5):547-558.
44. Zhang DE, Hetherington CJ, Meyers S, et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol. 1996;16(3): 1231-1240.
45. Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
46. Belz GT, Nutt SL. Transcriptional programming of the dendritic cell network. Nat Rev Immunol. 2012;12(2):101-113.
47. Chen SS, Chen JF, Johnson PF, Muppala V, Lee YH. C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol. 2000;20(19):7292-7299.
48. Liu K, Nussenzweig MC. Development and homeostasis of dendritic cells. Eur J Immunol. 2010;40(8):2099-2102.
49. Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev. 2010;234(1): 45-54.