The protective effects of sildenafil in acute lung injury in a rat model of severe scald burn: A biochemical and histopathological study

Burns

Volumn 39, Issue 6, 2013, Pages 1193-1199

  Gokakin, Ali Kagan ^a   Deveci, Koksal ^a   Kurt, Atilla ^a   Karakus, Boran Cihat ^a   Duger, Cevdet ^a   Tuzcu, Mehmet ^a   Topcu, Omer ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Acute lung injury; Burn; Sildenafil

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SILDENAFIL;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BODY SURFACE; CLINICAL EVALUATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; SCALD; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ACUTE LUNG INJURY; BURN; SILDENAFIL;

ACUTE LUNG INJURY; ANIMALS; BIOLOGICAL MARKERS; BURNS; CATALASE; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE PEROXIDASE; MALONDIALDEHYDE; OXIDATIVE STRESS; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, WISTAR; SULFONES;

EID: 84880933162     PISSN: 03054179     EISSN: 18791409     Source Type: Journal    
DOI: 10.1016/j.burns.2012.12.017     Document Type: Article

References (35)

1. A. Parihar, M.S. Parihar, S. Milner, and S. Bhat Oxidative stress and anti-oxidative mobilization in burn injury Burns 34 2008 6 17 Review
2. J. Sasaki, S. Fujishima, H. Iwamura, K. Wakitani, S. Aiso, and N. Aikawa Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition Am J Physiol Lung Cell Mol Physiol 284 2003 270 280
3. Gao C, Liu Y, Ma L, Wang S. Protective effects of ulinastatin on pulmonary damage in rats following scald injury. Burns 2012 [Epub ahead of print].
4. Gao C, Liu Y, Ma L, Zhang X, Wang S. Effects of ligustrazine on pulmonary damage in rats following scald injury. Burns 2012 [Epub ahead of print].
5. L.J. Magnotti, D.Z. Xu, Q. Lu, and E.A. Deitch Gut-derived mesenteric lymph: a link between burn and lung injury Arch Surg 134 1999 1333 1341
6. J.W. Horton Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy Toxicology 189 2003 75 88 Review
7. K.M. Regula, K. Ens, and L.A. Kirshenbaum Mitochondria-assisted cell suicide: a license to kill J Mol Cell Cardiol 35 2003 559 567
8. J. Zhang, S.W. Sio, S. Moochhala, and M. Bhatia Role of hydrogen sulfide in severe burn injury-induced inflammation in mice Mol Med 16 2010 417 424
9. S.O. Iseri, Y. Ersoy, N. Gedik, F. Ercan, and I. Alican Protective role of adrenomedullin in burn-induced remote organ damage in the rat Regul Pept 146 2008 99 105
10. D. Avlan, H. Taşkinlar, L. Tamer, H. Camdeviren, H. Ozturhan, and C. Oztürk Protective effect of trapidil against oxidative organ damage in burn injury Burns 31 2005 859 865
11. V. Gürbüz, A. Corak, B.C. Yeǧen, H. Kurtel, and I. Alican Oxidative organ damage in a rat model of thermal injury: the effect of cyclosporin A Burns 23 1997 37 42
12. A. Gürer, M. Ozdoǧan, A.K. Gökakin, I. Gömceli, O. Gülbahar, and A.T. Arikök Tissue oxidative stress level and remote organ injury in two-hit trauma model of sequential burn injury and peritoneal sepsis are attenuated with N-acetylcysteine treatment in rats Ulus Travma Acil Cerrahi Derg 15 2009 1 6
13. H. Glossmann, G. Petrischor, and G. Bartsch Molecular mechanisms of the effects of sildenafil (VIAGRA) Exp Gerontol 34 1999 305 318 Review
14. M. Humbert, O. Sitbon, and G. Simonneau Treatment of pulmonary arterial hypertension N Engl J Med 351 2004 1425 1436
15. F. Ladha, S. Bonnet, F. Eaton, K. Hashimoto, G. Korbutt, and B. Thebaud Sildenafil improves alveolar growth and pulmonary hypertension in hyperoxia-induced lung injury Am J Respir Crit Care Med 172 2005 750 756
16. A.R. Hemnes, A. Zaiman, and H.C. Champion PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation Am J Physiol Lung Cell Mol Physiol 294 2008 24 33
17. K. Hart, D. Baur, J. Hodam, L. Lesoon-Wood, M. Parham, and K. Keith Short- and long-term effects of sildenafil on skin flap survival in rats Laryngoscope 116 2006 522 528
18. R. Ayten, Z. Cetinkaya, M. Girgin, I. Ozercan, B. Ustundag, and E. Aygen The effects of intraperitoneal sildenafil administration on healing of left colonic anastomoses and intra-abdominal adhesion formation in the presence of intra-abdominal infection Dis Colon Rectum 51 2008 1837 1841
19. B. Karakoyun, U. Uslu, F. Ercan, M.S. Aydin, M. Yuksel, and A.V. Ogunc The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis Life Sci 89 2011 402 407
20. E. Cadirci, Z. Halici, F. Odabasoglu, A. Albayrak, E. Karakus, and D. Unal Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study Clin Exp Immunol 166 2011 374 384
21. S.O. Iseri, Y. Ersoy, F. Ercan, M. Yuksel, P. Atukeren, and K. Gumustas The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat J Gastroenterol Hepatol 24 2009 1142 1148
22. H. Uzun, D. Konukoglu, M.K. Nuri, E.Y. Ersoy, S. Ozçevik, and N. Yavuz The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: its relationship between nitric oxide and oxidative stress World J Surg 32 2008 2107 2113
23. A. Yildirim, Y. Ersoy, F. Ercan, P. Atukeren, K. Gumustas, and U. Uslu Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis Pulm Pharmacol Ther 23 2010 215 221
24. D.K. Walker, M.J. Ackland, G.C. James, G.J. Muirhead, D.J. Rance, and P. Wastall Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man Xenobiotica 29 1999 297 310
25. J.M. Stevenson, R.L. Gamelli, and R. Shankar A mouse model of burn wounding and sepsis Methods Mol Med. 78 2003 95 105
26. D.E. Paglia, and W.N. Valentine Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J Lab Clin Med 70 1967 158 169
27. L.H. Johansson, and B. Johansson A spectrophotometric method for determination of catalase activity in small tissue samples Anal Biochem 174 1988 331 336
28. C.R. Wheeler, J.A. Salzman, N.M. Elsayed, S.T. Omaye, and D.W. Omaye Jr. Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity Anal Biochem 184 1990 193 199
29. O. Erel A new automated colorimetric method for measuring total oxidant status Clin Biochem 38 2005 1103 1111
30. O. Erel A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation Clin Biochem 37 2004 277 285
31. G.O. Till, J.R. Hatherill, W.W. Tourtellotte, M.J. Lutz, and P.A. Ward Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical Am J Pathol 119 1985 376 384
32. M. Hosnuter, A. Gurel, O. Babuccu, F. Armutcu, E. Kargi, and A. Isikdemir The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury Burns 30 2004 121 125
33. R.H. Demling, and C. LaLonde Systemic lipid peroxidation inflammation induced by thermal injury persists into the post-resuscitation period J Trauma 30 1990 69 71
34. E. Lubos, J. Loscalzo, and D.E. Handy Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 15 2011 1957 1997
35. E.I. Saygili, S.N. Aksoy, B. Gurler, A. Aksoy, O. Erel, and M. Ozaslan Oxidant/antioxidant status of patients with diabetic and senile cataract Biotechnol & Biotechnol Eq 24 2010 1648 1652